KEGG   DRUG: PertuzumabHelp
Entry
D05446                      Drug                                   

Name
Pertuzumab (USAN/INN);
Pertuzumab (genetical recombination) (JAN);
Perjeta (TN)
Product
Remark
Therapeutic category: 4291
ATC code: L01XC13
Product: D05446<JP/US>
Efficacy
Antineoplastic, Receptor tyrosine kinase inhibitor, Anti-HER2 antibody
  Disease
Breast cancer (HER2 positive) [DS:H00031]
Comment
Monoclonal antibody
Target
ERBB2 (HER2, CD340) [HSA_VAR:2064v1 2064v3] [HSA:2064] [KO:K05083]
  Network
N10009  Tyrosine kinase inhibitor to HER2 overexpression/amplification
  Pathway
hsa04012  ErbB signaling pathway
hsa05200  Pathways in cancer
hsa05224  Breast cancer
Structure map
map07045  Antineoplastics - protein kinases inhibitors
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 L ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
  L01 ANTINEOPLASTIC AGENTS
   L01X OTHER ANTINEOPLASTIC AGENTS
    L01XC Monoclonal antibodies
     L01XC13 Pertuzumab
      D05446  Pertuzumab (USAN/INN) <JP/US>
Therapeutic category of drugs in Japan [BR:br08301]
 4  Agents affecting cellular function
  42  Antineoplastics
   429  Miscellaneous
    4291  Other Antitumors
     D05446  Pertuzumab (USAN/INN); Pertuzumab (genetical recombination) (JAN)
Target-based classification of drugs [BR:br08310]
 Protein kinases
  Receptor tyrosine kinases (RTK)
   EGFR family
    ERBB2 (HER2, CD340) [HSA_VAR:2064v1 2064v3]
     D05446  Pertuzumab (USAN/INN) <JP/US>
Antineoplastics [br08340.html]
 D05446
New drug approvals in the USA [br08319.html]
 New Molecular Entity and New Therapeutic Biological Product Approvals
  D05446
New drug approvals in Europe [br08329.html]
 European public assessment reports (EPAR) authorised medicine
  D05446
New drug approvals in Japan [br08318.html]
 Drugs with new active ingredients
  D05446
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D05446
Pharmacogenomic biomarkers [br08341.html]
 Companion diagnostics
  D05446
BRITE hierarchy
Other DBs
CAS: 380610-27-5
PubChem: 47207115
LinkDB All DBs

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