KEGG   VARIANT: 2064v3
Entry
2064v3                      Variant                                
Name
ERBB2 amplification
Type
Gain of function
Gene
ERBB2  erb-b2 receptor tyrosine kinase 2 [KO:K05083]
Organism
hsa_var Human gene variants (Homo sapiens)
Variation
amplification
ClinVar: 148363 58696 57282
dbVar: nsv817369 nsv531185 nsv529527
Network
nt06210  ERK signaling (cancer)
nt06214  PI3K signaling (cancer)
nt06261  Gastric cancer
nt06526  MAPK signaling
nt06530  PI3K signaling
Disease
H00018  Gastric cancer
Drug target
Neratinib (DG02303): D10898<US>
Pertuzumab: D05446<JP/US>
Trastuzumab emtansine: D09980<JP/US>
Reference
PMID:26267324
  Authors
Riquelme I, Saavedra K, Espinoza JA, Weber H, Garcia P, Nervi B, Garrido M, Corvalan AH, Roa JC, Bizama C
  Title
Molecular classification of gastric cancer: Towards a pathway-driven targeted therapy.
  Journal
Oncotarget 6:24750-79 (2015)
DOI:10.18632/oncotarget.4990
Reference
PMID:16154715
  Authors
Stock M, Otto F
  Title
Gene deregulation in gastric cancer.
  Journal
Gene 360:1-19 (2005)
DOI:10.1016/j.gene.2005.06.026
Reference
PMID:15224192
  Authors
Zheng L, Wang L, Ajani J, Xie K.
  Title
Molecular basis of gastric cancer development and progression.
  Journal
Gastric Cancer 7:61-77 (2004)
DOI:10.1007/s10120-004-0277-4
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