KEGG   DRUG: Prasugrel hydrochloride
Entry
D05597                      Drug                                   
Name
Prasugrel hydrochloride (JAN/USAN);
Effient (TN)
Product
EFFIENT (Cosette Pharmaceuticals), EFFIENT (Daiichi Sankyo)
  Generic
PRASUGREL (A-S Medication Solutions), PRASUGREL (Accord Healthcare), PRASUGREL (Amneal Pharmaceuticals LLC), PRASUGREL (Apotex Corp.), PRASUGREL (Aurobindo Pharma Limited), PRASUGREL (Golden State Medical Supply), PRASUGREL (Mylan Pharmaceuticals), PRASUGREL (Panacea Biotec Limited)
Formula
C20H20FNO3S. HCl
Exact mass
409.0915
Mol weight
409.902
Structure
Class
Blood modifier agent
 DG01950  Antithrombotic agent
  DG01712  Antiplatelet agent
   DG01808  Thienopyridine
 DG01809  P2Y12 receptor antagonist
  DG01808  Thienopyridine
Metabolizing enzyme substrate
 DG02919  CYP2B6 substrate
 DG01633  CYP3A/CYP3A4 substrate
Metabolizing enzyme inhibitor
 DG02892  CYP2B6 inhibitor
Remark
Therapeutic category: 3399
ATC code: B01AC22
Product: D05597<JP/US>
Efficacy
Platelet aggregation inhibitor, Purinergic receptor P2Y12 antagonist
  Disease
Unstable angina [DS:H01632]
Myocardial infarction [DS:H01730]
Comment
Thienopyridine derivative
Target
P2RY12 [HSA:64805] [KO:K04298]
  Pathway
hsa04611  Platelet activation
Metabolism
Enzyme: CYP3A [HSA:1576 1577 1551], CYP2B6 [HSA:1555]
Interaction
CYP inhibition: CYP2B6 [HSA:1555]
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 B BLOOD AND BLOOD FORMING ORGANS
  B01 ANTITHROMBOTIC AGENTS
   B01A ANTITHROMBOTIC AGENTS
    B01AC Platelet aggregation inhibitors excl. heparin
     B01AC22 Prasugrel
      D05597  Prasugrel hydrochloride (JAN/USAN) <JP/US>
USP drug classification [BR:br08302]
 Blood Products and Modifiers
  Platelet Modifying Agents
   Adenosine Diphosphate P2Y12 Inhibitors
    Prasugrel
     D05597  Prasugrel hydrochloride (JAN/USAN)
Therapeutic category of drugs in Japan [BR:br08301]
 3  Agents affecting metabolism
  33  Blood and body fluid agents
   339  Miscellaneous
    3399  Others
     D05597  Prasugrel hydrochloride (JAN/USAN)
Drug groups [BR:br08330]
 Blood modifier agent
  DG01950  Antithrombotic agent
   DG01712  Antiplatelet agent
    DG01808  Thienopyridine
     D05597  Prasugrel hydrochloride
  DG01809  P2Y12 receptor antagonist
   DG01808  Thienopyridine
    D05597  Prasugrel hydrochloride
 Metabolizing enzyme substrate
  DG02919  CYP2B6 substrate
   D05597  Prasugrel hydrochloride
  DG01633  CYP3A/CYP3A4 substrate
   D05597  Prasugrel hydrochloride
 Metabolizing enzyme inhibitor
  DG02892  CYP2B6 inhibitor
   D05597  Prasugrel hydrochloride
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Purine / pyrimidine
    P2RY12
     D05597  Prasugrel hydrochloride (JAN/USAN) <JP/US>
New drug approvals in the USA [br08319.html]
 New molecular entities and new therapeutic biological products
  D05597
New drug approvals in Europe [br08329.html]
 European public assessment reports (EPAR) authorised medicine
  D05597
New drug approvals in Japan [br08318.html]
 Drugs with new active ingredients
  D05597
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D05597
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D05597
Pharmacogenomic biomarkers [br08341.html]
 Polymorphisms and mutations affecting drug response
  D05597
Other DBs
CAS: 389574-19-0
PubChem: 47207260
ChEBI: 87697
LigandBox: D05597
LinkDB
KCF data

ATOM        27
            1   N1y N    17.0100  -15.7500
            2   C1x C    17.0100  -14.3500
            3   C1x C    18.2000  -13.6500
            4   C8y C    19.4600  -14.3500
            5   C8y C    19.4600  -15.7500
            6   C1x C    18.2000  -16.4500
            7   S2x S    20.7900  -13.9300
            8   C8y C    21.5600  -15.0500
            9   C8x C    20.7900  -16.1700
            10  O7a O    22.9600  -15.0500
            11  C7a C    23.6600  -13.8600
            12  C1a C    25.0600  -13.8600
            13  O6a O    22.9600  -12.6700
            14  C1c C    15.8200  -16.4500
            15  C8y C    14.6300  -15.7500
            16  C5a C    15.8200  -17.8500
            17  O5a O    17.0100  -18.5500
            18  C1y C    14.6300  -18.5500
            19  C8y C    14.6300  -14.3500
            20  C8x C    13.3700  -13.6500
            21  C8x C    12.1800  -14.3500
            22  C8x C    12.1800  -15.7500
            23  C8x C    13.3700  -16.4500
            24  C1x C    13.2300  -18.5500
            25  C1x C    13.9300  -19.7400
            26  X   F    15.8200  -13.6500
            27  X   Cl   24.7800  -18.0600
BOND        29
            1     1   2 1
            2     2   3 1
            3     3   4 1
            4     4   5 2
            5     5   6 1
            6     1   6 1
            7     4   7 1
            8     7   8 1
            9     8   9 2
            10    5   9 1
            11    8  10 1
            12   10  11 1
            13   11  12 1
            14   11  13 2
            15    1  14 1
            16   14  15 1
            17   14  16 1
            18   16  17 2
            19   16  18 1
            20   15  19 2
            21   19  20 1
            22   20  21 2
            23   21  22 1
            24   22  23 2
            25   15  23 1
            26   18  24 1
            27   24  25 1
            28   25  18 1
            29   19  26 1

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