KEGG   DRUG: RufinamideHelp
Entry
D05775                      Drug                                   

Name
Rufinamide (JAN/USAN/INN);
Banzel (TN)
Product
Formula
C10H8F2N4O
Exact mass
238.0666
Mol weight
238.1935
Structure
Mol fileKCF fileDB search
Class
Neuropsychiatric agent
 DG02034  Carboxamide antiepileptics
Cyp inducer
 DG01897  CYP3A5 inducer
Remark
Therapeutic category: 1139
ATC code: N03AF03
Product: D05775<JP/US>
Efficacy
Antiepileptic
  Disease
Lennox-Gastaut syndrome [DS:H01813]
Comment
Carboxamide derivative
Rufinamide is a weak inhibitor of CYP 2E1.
Rufinamide is a weak inducer of CYP3A4 enzymes.
Target
SCN1A [HSA:6323] [KO:K04833]
SCN2A [HSA:6326] [KO:K04834]
SCN3A [HSA:6328] [KO:K04836]
SCN4A [HSA:6329] [KO:K04837]
SCN5A [HSA:6331] [KO:K04838]
SCN8A [HSA:6334] [KO:K04840]
SCN9A [HSA:6335] [KO:K04841]
SCN10A [HSA:6336] [KO:K04842]
SCN11A [HSA:11280] [KO:K04843]
  Pathway
hsa04728  Dopaminergic synapse
Interaction
Drug interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N03 ANTIEPILEPTICS
   N03A ANTIEPILEPTICS
    N03AF Carboxamide derivatives
     N03AF03 Rufinamide
      D05775  Rufinamide (JAN/USAN/INN) <JP/US>
USP drug classification [BR:br08302]
 Anticonvulsants
  Sodium Channel Agents
   Rufinamide
    D05775  Rufinamide (JAN/USAN/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  11  Agents affecting central nervous system
   113  Antiepileptics
    1139  Others
     D05775  Rufinamide (JAN/USAN/INN)
Target-based classification of drugs [BR:br08310]
 Ion channels
  Voltage-gated ion channels
   Sodium channels
    SCN1A
     D05775  Rufinamide (JAN/USAN/INN) <JP/US>
    SCN2A
     D05775  Rufinamide (JAN/USAN/INN) <JP/US>
    SCN3A
     D05775  Rufinamide (JAN/USAN/INN) <JP/US>
    SCN4A
     D05775  Rufinamide (JAN/USAN/INN) <JP/US>
    SCN5A
     D05775  Rufinamide (JAN/USAN/INN) <JP/US>
    SCN8A
     D05775  Rufinamide (JAN/USAN/INN) <JP/US>
    SCN9A
     D05775  Rufinamide (JAN/USAN/INN) <JP/US>
    SCN10A
     D05775  Rufinamide (JAN/USAN/INN) <JP/US>
    SCN11A
     D05775  Rufinamide (JAN/USAN/INN) <JP/US>
Drug classes of therapeutic agents [br08360.html]
 Neurological agents
  D05775
New drug approvals in the USA [br08319.html]
 New Molecular Entity and New Therapeutic Biological Product Approvals
  D05775
New drug approvals in Europe [br08329.html]
 European public assessment reports (EPAR) authorised medicine
  D05775
New drug approvals in Japan [br08318.html]
 Drugs with new active ingredients
  D05775
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D05775
BRITE hierarchy
Other DBs
CAS: 106308-44-5
PubChem: 47207436
ChEMBL: CHEMBL1201754
LigandBox: D05775
NIKKAJI: J575.180B
LinkDB All DBs
KCF data Show

ATOM        17
            1   C8x C    27.5379  -17.1661
            2   C8x C    27.5379  -18.5624
            3   C8x C    28.7471  -19.2605
            4   C8y C    29.9564  -18.5624
            5   C8y C    29.9564  -17.1661
            6   C8y C    28.7471  -16.4679
            7   X   F    28.7471  -15.0718
            8   X   F    31.1843  -19.2715
            9   C1b C    31.1843  -16.4570
            10  N4y N    32.3863  -17.1508
            11  N5x N    32.4321  -18.5562
            12  N5x N    33.7844  -18.9475
            13  C8y C    34.5745  -17.7822
            14  C8x C    33.7104  -16.6707
            15  C5a C    35.9312  -17.8076
            16  N1a N    36.5583  -19.0940
            17  O5a O    36.6991  -16.6707
BOND        18
            1     1   2 2
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 2
            6     1   6 1
            7     6   7 1
            8     4   8 1
            9     5   9 1
            10    9  10 1
            11   10  11 1
            12   11  12 2
            13   12  13 1
            14   13  14 2
            15   10  14 1
            16   13  15 1
            17   15  16 1
            18   15  17 2

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