KEGG   DRUG: Rufinamide
Entry
D05775                      Drug                                   

Name
Rufinamide (JAN/USP/INN);
Banzel (TN)
Product
  Generic
Formula
C10H8F2N4O
Exact mass
238.0666
Mol weight
238.1935
Structure
Class
Neuropsychiatric agent
 DG03199  Antiepileptic agent
  DG02034  Carboxamide antiepileptic
Metabolizing enzyme substrate
 DG02970  CES substrate
Remark
Therapeutic category: 1139
ATC code: N03AF03
Product: D05775<JP/US>
Efficacy
Antiepileptic
  Disease
Lennox-Gastaut syndrome [DS:H01813]
Comment
Carboxamide derivative
Target
SCN1A [HSA:6323] [KO:K04833]
SCN2A [HSA:6326] [KO:K04834]
SCN3A [HSA:6328] [KO:K04836]
SCN4A [HSA:6329] [KO:K04837]
SCN5A [HSA:6331] [KO:K04838]
SCN8A [HSA:6334] [KO:K04840]
SCN9A [HSA:6335] [KO:K04841]
SCN10A [HSA:6336] [KO:K04842]
SCN11A [HSA:11280] [KO:K04843]
  Pathway
hsa04728  Dopaminergic synapse
Metabolism
Enzyme: CES [HSA:1066 8824 23491 221223]
Interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N03 ANTIEPILEPTICS
   N03A ANTIEPILEPTICS
    N03AF Carboxamide derivatives
     N03AF03 Rufinamide
      D05775  Rufinamide (JAN/USP/INN) <JP/US>
USP drug classification [BR:br08302]
 Anticonvulsants
  Sodium Channel Agents
   Rufinamide
    D05775  Rufinamide (JAN/USP/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  11  Agents affecting central nervous system
   113  Antiepileptics
    1139  Others
     D05775  Rufinamide (JAN/USP/INN)
Target-based classification of drugs [BR:br08310]
 Ion channels
  Voltage-gated ion channels
   Sodium channels
    SCN1A
     D05775  Rufinamide (JAN/USP/INN) <JP/US>
    SCN2A
     D05775  Rufinamide (JAN/USP/INN) <JP/US>
    SCN3A
     D05775  Rufinamide (JAN/USP/INN) <JP/US>
    SCN4A
     D05775  Rufinamide (JAN/USP/INN) <JP/US>
    SCN5A
     D05775  Rufinamide (JAN/USP/INN) <JP/US>
    SCN8A
     D05775  Rufinamide (JAN/USP/INN) <JP/US>
    SCN9A
     D05775  Rufinamide (JAN/USP/INN) <JP/US>
    SCN10A
     D05775  Rufinamide (JAN/USP/INN) <JP/US>
    SCN11A
     D05775  Rufinamide (JAN/USP/INN) <JP/US>
New drug approvals in the USA [br08319.html]
 New molecular entities and new therapeutic biological products
  D05775
New drug approvals in Europe [br08329.html]
 European public assessment reports (EPAR) authorised medicine
  D05775
New drug approvals in Japan [br08318.html]
 Drugs with new active ingredients
  D05775
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D05775
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D05775
Other DBs
CAS: 106308-44-5
PubChem: 47207436
ChEMBL: CHEMBL1201754
LigandBox: D05775
NIKKAJI: J575.180B
LinkDB
KCF data

ATOM        17
            1   C8x C    27.5379  -17.1661
            2   C8x C    27.5379  -18.5624
            3   C8x C    28.7471  -19.2605
            4   C8y C    29.9564  -18.5624
            5   C8y C    29.9564  -17.1661
            6   C8y C    28.7471  -16.4679
            7   X   F    28.7471  -15.0718
            8   X   F    31.1843  -19.2715
            9   C1b C    31.1843  -16.4570
            10  N4y N    32.3863  -17.1508
            11  N5x N    32.4321  -18.5562
            12  N5x N    33.7844  -18.9475
            13  C8y C    34.5745  -17.7822
            14  C8x C    33.7104  -16.6707
            15  C5a C    35.9312  -17.8076
            16  N1a N    36.5583  -19.0940
            17  O5a O    36.6991  -16.6707
BOND        18
            1     1   2 2
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 2
            6     1   6 1
            7     6   7 1
            8     4   8 1
            9     5   9 1
            10    9  10 1
            11   10  11 1
            12   11  12 2
            13   12  13 1
            14   13  14 2
            15   10  14 1
            16   13  15 1
            17   15  16 1
            18   15  17 2

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