KEGG   DRUG: Synthetic conjugated estrogens, B
Entry
D05987            Mixture   Drug                                   

Name
Synthetic conjugated estrogens, B (USAN);
Enjuvia (TN)
Component
Estrone sodium sulfate [DR:D00312], Sodium equilin sulfate [CPD:C13416], Sodium dihydroequilin sulfate, Sodium estradiol sulfate, Sodium dihydroequilenin sulfate, Sodium dehydroestrone sulfate
Class
Endocrine and hormonal agent
 DG01986  Estrogen
 DG01584  Estrogen receptor agonist
Metabolizing enzyme substrate
 DG01633  CYP3A/CYP3A4 substrate
  DG02913  CYP3A4 substrate
Transporter inhibitor
 DG02882  ABCB11 inhibitor
Remark
ATC code: G03CA57
Chemical structure group: DG00465
Product (DG00465): D04070<JP/US>
Efficacy
Replenisher (estrogen), Estrogen receptor agonist
Comment
Plant origin
Treatment of menopausal symptom
Metabolism
Enzyme: CYP3A4 [HSA:1576]
Interaction
Transporter inhibition: ABCB11 [HSA:8647]
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 G GENITO URINARY SYSTEM AND SEX HORMONES
  G03 SEX HORMONES AND MODULATORS OF THE GENITAL SYSTEM
   G03C ESTROGENS
    G03CA Natural and semisynthetic estrogens, plain
     G03CA57 Conjugated estrogens
      D05987  Synthetic conjugated estrogens, B (USAN)
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D05987
 Drug transporters
  D05987
Other DBs
PubChem: 47207645
DrugBank: DB00286
LinkDB

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