KEGG   DRUG: Lepirudin
Entry
D06880                      Drug                                   
Name
Lepirudin (INN);
Refludan (TN)
Formula
C287H440N80O111S6
Exact mass
6974.9569
Mol weight
6979.44
Sequence
Leu Thr Tyr Thr Asp Cys Thr Glu Ser Gly Gln Asn Leu Cys Leu Cys
Glu Gly Ser Asn Val Cys Gly Gln Gly Asn Lys Cys Ile Leu Gly Ser
Asp Gly Glu Lys Asn Gln Cys Val Thr Gly Glu Gly Thr Pro Lys Pro
Gln Ser His Asn Asp Gly Asp Phe Glu Glu Ile Pro Glu Glu Tyr Leu
Gln (Disulfide bridge: 6-14, 16-28, 22-39)
  Type
Peptide
Class
Blood modifier agent
 DG01950  Antithrombotic agent
  DG01511  Thrombin inhibitor
Remark
ATC code: B01AE02
Efficacy
Anticoagulant, Thrombin inhibitor
Comment
Peptide
Hirudin derivative
Target
F2 [HSA:2147] [KO:K01313]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04610  Complement and coagulation cascades
Interaction
Structure map
map07049  Antithrombosis agents
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 B BLOOD AND BLOOD FORMING ORGANS
  B01 ANTITHROMBOTIC AGENTS
   B01A ANTITHROMBOTIC AGENTS
    B01AE Direct thrombin inhibitors
     B01AE02 Lepirudin
      D06880  Lepirudin (INN)
Drug groups [BR:br08330]
 Blood modifier agent
  DG01950  Antithrombotic agent
   DG01511  Thrombin inhibitor
    D06880  Lepirudin
Target-based classification of drugs [BR:br08310]
 Enzymes
  Hydrolases (EC3)
   Serine peptidases
    F2
     D06880  Lepirudin (INN)
Other DBs
CAS: 138068-37-8
PubChem: 49661780
ChEBI: 142437
LinkDB

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