KEGG   DRUG: Dexamethasone cipecilateHelp
Entry
D07073                      Drug                                   

Name
Dexamethasone cipecilate (JAN/INN)
Formula
C33H43FO7
Exact mass
570.2993
Mol weight
570.6887
Structure
Mol fileKCF fileDB search
Simcomp SIMCOMP
Class
Anti-inflammatory
 DG01955  Corticosteroid
  DG02068  Glucocorticoid
Metabolizing enzyme substrate
 DG01892  CYP1A2 substrate
 DG02913  CYP3A4 substrate
 DG02970  CES substrate
Metabolizing enzyme inducer
 DG01635  CYP3A4 inducer
Remark
Therapeutic category: 1329
ATC code: A01AC02 C05AA09 D07AB19 D07XB05 D10AA03 H02AB02 R01AD03 S01BA01 S01CB01 S02BA06 S03BA01
Chemical structure group: DG00011
Product (DG00011): D00292<JP/US> D00975<JP/US> D01510<JP> D01615<JP> D01632<JP> D01948<JP> D07073<JP>
Efficacy
Antiallergic, Anti-inflammatory, Glucocorticoid receptor agonist
Target
NR3C1 (GR) [HSA:2908] [KO:K05771]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
Metabolism
Enzyme: CYP3A4 [HSA:1576], CYP1A2 [HSA:1544], CES [HSA:1066 8824 23491 221223]
Interaction
Drug interaction
Structure map
map07225  Glucocorticoid and mineralocorticoid receptor agonists/antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 A ALIMENTARY TRACT AND METABOLISM
  A01 STOMATOLOGICAL PREPARATIONS
   A01A STOMATOLOGICAL PREPARATIONS
    A01AC Corticosteroids for local oral treatment
     A01AC02 Dexamethasone
      D07073  Dexamethasone cipecilate (JAN/INN) <JP>
 C CARDIOVASCULAR SYSTEM
  C05 VASOPROTECTIVES
   C05A AGENTS FOR TREATMENT OF HEMORRHOIDS AND ANAL FISSURES FOR TOPICAL USE
    C05AA Corticosteroids
     C05AA09 Dexamethasone
      D07073  Dexamethasone cipecilate (JAN/INN) <JP>
 D DERMATOLOGICALS
  D07 CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS
   D07A CORTICOSTEROIDS, PLAIN
    D07AB Corticosteroids, moderately potent (group II)
     D07AB19 Dexamethasone
      D07073  Dexamethasone cipecilate (JAN/INN) <JP>
   D07X CORTICOSTEROIDS, OTHER COMBINATIONS
    D07XB Corticosteroids, moderately potent, other combinations
     D07XB05 Dexamethasone
      D07073  Dexamethasone cipecilate (JAN/INN) <JP>
  D10 ANTI-ACNE PREPARATIONS
   D10A ANTI-ACNE PREPARATIONS FOR TOPICAL USE
    D10AA Corticosteroids, combinations for treatment of acne
     D10AA03 Dexamethasone
      D07073  Dexamethasone cipecilate (JAN/INN) <JP>
 H SYSTEMIC HORMONAL PREPARATIONS, EXCL. SEX HORMONES AND INSULINS
  H02 CORTICOSTEROIDS FOR SYSTEMIC USE
   H02A CORTICOSTEROIDS FOR SYSTEMIC USE, PLAIN
    H02AB Glucocorticoids
     H02AB02 Dexamethasone
      D07073  Dexamethasone cipecilate (JAN/INN) <JP>
 R RESPIRATORY SYSTEM
  R01 NASAL PREPARATIONS
   R01A DECONGESTANTS AND OTHER NASAL PREPARATIONS FOR TOPICAL USE
    R01AD Corticosteroids
     R01AD03 Dexamethasone
      D07073  Dexamethasone cipecilate (JAN/INN) <JP>
 S SENSORY ORGANS
  S01 OPHTHALMOLOGICALS
   S01B ANTIINFLAMMATORY AGENTS
    S01BA Corticosteroids, plain
     S01BA01 Dexamethasone
      D07073  Dexamethasone cipecilate (JAN/INN) <JP>
   S01C ANTIINFLAMMATORY AGENTS AND ANTIINFECTIVES IN COMBINATION
    S01CB Corticosteroids/antiinfectives/mydriatics in combination
     S01CB01 Dexamethasone
      D07073  Dexamethasone cipecilate (JAN/INN) <JP>
  S02 OTOLOGICALS
   S02B CORTICOSTEROIDS
    S02BA Corticosteroids
     S02BA06 Dexamethasone
      D07073  Dexamethasone cipecilate (JAN/INN) <JP>
  S03 OPHTHALMOLOGICAL AND OTOLOGICAL PREPARATIONS
   S03B CORTICOSTEROIDS
    S03BA Corticosteroids
     S03BA01 Dexamethasone
      D07073  Dexamethasone cipecilate (JAN/INN) <JP>
USP drug classification [BR:br08302]
 Hormonal Agents, Stimulant/Replacement/Modifying (Adrenal)
  Dexamethasone
   D07073  Dexamethasone cipecilate (JAN/INN)
  Dexamethasone
   D07073  Dexamethasone cipecilate (JAN/INN)
 Inflammatory Bowel Disease Agents
  Glucocorticoids
   Dexamethasone
    D07073  Dexamethasone cipecilate (JAN/INN)
 Ophthalmic Agents
  Ophthalmic Anti-inflammatories
   Dexamethasone
    D07073  Dexamethasone cipecilate (JAN/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  13  Agents affecting sensory organs
   132  Otic and nasal agents
    1329  Others
     D07073  Dexamethasone cipecilate (JAN/INN)
Target-based classification of drugs [BR:br08310]
 Nuclear receptors
  Estrogen like receptors
   3-Ketosteroid receptor
    NR3C1 (GR)
     D07073  Dexamethasone cipecilate (JAN/INN) <JP>
New drug approvals in Japan [br08318.html]
 Drugs with new active ingredients
  D07073
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D07073
BRITE hierarchy
Other DBs
CAS: 132245-57-9
PubChem: 51091415
LigandBox: D07073
LinkDB All DBs
KCF data Show

ATOM        41
            1   C2x C    21.1400  -21.0000
            2   C5x C    21.1400  -22.3300
            3   C2x C    22.3300  -23.0300
            4   C2y C    23.5200  -22.3300
            5   C1z C    23.5200  -21.0000
            6   C2x C    22.3300  -20.3000
            7   C1x C    24.6400  -23.0300
            8   C1x C    25.8300  -22.3300
            9   C1y C    25.8300  -21.0000
            10  C1z C    24.6400  -20.3000
            11  C1y C    27.0200  -20.3000
            12  C1z C    27.0200  -18.9700
            13  C1x C    25.8300  -18.3400
            14  C1y C    24.6400  -18.9700
            15  C1x C    29.3300  -20.3000
            16  C1y C    29.3300  -18.9700
            17  C1z C    28.1400  -18.3400
            18  C1a C    23.5200  -19.6700
            19  C1a C    27.0200  -17.6400
            20  C1a C    30.4500  -18.3400
            21  C5a C    28.1400  -16.6600
            22  X   F    24.6400  -21.7000
            23  O7a O    29.8900  -17.2200
            24  O5x O    20.0200  -23.0300
            25  O5a O    29.3300  -15.9600
            26  C1b C    27.0200  -15.9600
            27  O7a O    25.8300  -16.6600
            28  C7a C    31.2200  -17.2200
            29  O6a O    31.9200  -18.4100
            30  C1y C    31.9200  -16.0300
            31  C7a C    24.6400  -15.9600
            32  O6a O    24.6400  -14.5600
            33  C1y C    23.4500  -16.6600
            34  C1x C    22.7500  -15.4700
            35  C1x C    21.3500  -15.4700
            36  C1x C    20.6500  -16.6600
            37  C1x C    21.3500  -17.8500
            38  C1x C    22.7500  -17.8500
            39  C1x C    33.3722  -15.8020
            40  C1x C    32.4961  -14.7350
            41  O1a O    24.6400  -17.5700
BOND        46
            1     1   2 1
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 1
            6     1   6 2
            7     4   7 1
            8     7   8 1
            9     8   9 1
            10    9  10 1
            11    5  10 1
            12    9  11 1
            13   11  12 1
            14   12  13 1
            15   13  14 1
            16   10  14 1
            17   11  15 1
            18   15  16 1
            19   16  17 1
            20   12  17 1
            21    5  18 1 #Up
            22   12  19 1 #Up
            23   16  20 1 #Down
            24   17  21 1 #Up
            25   10  22 1 #Down
            26   17  23 1 #Down
            27    2  24 2
            28   21  25 2
            29   21  26 1
            30   26  27 1
            31   23  28 1
            32   28  29 2
            33   28  30 1
            34   27  31 1
            35   31  32 2
            36   31  33 1
            37   33  34 1
            38   34  35 1
            39   35  36 1
            40   36  37 1
            41   37  38 1
            42   33  38 1
            43   30  39 1
            44   39  40 1
            45   40  30 1
            46   14  41 1 #Up

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