KEGG   DRUG: Chlorphenamine
Entry
D07398                      Drug                                   

Name
Chlorphenamine (INN);
Chlorpheniramine;
Clofeniramina (TN)
Formula
C16H19ClN2
Exact mass
274.1237
Mol weight
274.7885
Structure
Simcomp
Class
Anti-allergic agent
 DG01557  Histamine receptor antagonist
  DG01482  Histamine receptor H1 antagonist
Remark
Same as: C06905
ATC code: R06AB04
Chemical structure group: DG01099
Product (DG01099): D00665<JP>
Product (mixture): D11075<US>
Efficacy
Antiallergic, H1 receptor antagonist
Target
HRH1 [HSA:3269] [KO:K04149]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04750  Inflammatory mediator regulation of TRP channels
Interaction
Structure map
map07212  Histamine H1 receptor antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 R RESPIRATORY SYSTEM
  R06 ANTIHISTAMINES FOR SYSTEMIC USE
   R06A ANTIHISTAMINES FOR SYSTEMIC USE
    R06AB Substituted alkylamines
     R06AB04 Chlorphenamine
      D07398  Chlorphenamine (INN)
Classification of Japanese OTC drugs [BR:br08313]
 Agents for integumentary system
  57 Analgesic, antipruritic, astringent, and anti-inflammatory remedies (incl. gel patches)
   D07398  Chlorphenamine (INN)
Risk category of Japanese OTC drugs [BR:br08312]
 Second-class OTC drugs
  Inorganic and organic chemicals
   Chlorphenamine
    D07398  Chlorphenamine (INN)
 Third-class OTC drugs
  Inorganic and organic chemicals
   Chlorphenamine
    D07398  Chlorphenamine (INN)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Histamine
    HRH1
     D07398  Chlorphenamine (INN)
Other DBs
CAS: 132-22-9
PubChem: 51091734
ChEBI: 52010
ChEMBL: CHEMBL505
LigandBox: D07398
NIKKAJI: J5.570K
LinkDB
KCF data

ATOM        19
            1   C8x C    13.8600  -15.8900
            2   C8y C    13.8600  -17.2900
            3   C8x C    15.0724  -17.9900
            4   C8x C    16.2849  -17.2900
            5   C8y C    16.2849  -15.8900
            6   C8x C    15.0724  -15.1900
            7   C1c C    17.5160  -15.1790
            8   C8y C    18.7212  -15.8747
            9   C8x C    18.7216  -17.2896
            10  C8x C    19.9342  -17.9893
            11  C8x C    21.1465  -17.2889
            12  C8x C    21.1460  -15.8739
            13  N5x N    19.9334  -15.1743
            14  C1b C    17.5157  -13.7901
            15  C1b C    18.7281  -13.0901
            16  N1c N    18.7281  -11.6901
            17  C1a C    19.9643  -10.9760
            18  C1a C    17.5397  -11.0038
            19  X   Cl   12.6476  -17.9900
BOND        20
            1     1   2 2
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 2
            6     1   6 1
            7     5   7 1
            8     7   8 1
            9     8   9 2
            10    9  10 1
            11   10  11 2
            12   11  12 1
            13   12  13 2
            14    8  13 1
            15    7  14 1
            16   14  15 1
            17   15  16 1
            18   16  17 1
            19   16  18 1
            20    2  19 1

» Japanese version   » Back

KEGG   DRUG: Dexchlorpheniramine
Entry
D07803                      Drug                                   

Name
Dexchlorpheniramine (INN);
d-Chloropheniramine;
Dapriton (TN)
Formula
C16H19ClN2
Exact mass
274.1237
Mol weight
274.7885
Structure
Simcomp
Class
Anti-allergic agent
 DG01557  Histamine receptor antagonist
  DG01482  Histamine receptor H1 antagonist
Metabolizing enzyme substrate
 DG01644  CYP2D6 substrate
 DG01633  CYP3A substrate
Metabolizing enzyme inhibitor
 DG01645  CYP2D6 inhibitor
Remark
Same as: C06946
ATC code: R06AB02
Chemical structure group: DG01098
Product (DG01098): D00668<JP/US>
Efficacy
Antiallergic, H1 receptor antagonist
Target
HRH1 [HSA:3269] [KO:K04149]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04750  Inflammatory mediator regulation of TRP channels
Metabolism
Enzyme: CYP2D6 [HSA:1565], CYP3A [HSA:1576 1577 1551]
Interaction
CYP inhibition: CYP2D6 [HSA:1565]
Structure map
map07212  Histamine H1 receptor antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 R RESPIRATORY SYSTEM
  R06 ANTIHISTAMINES FOR SYSTEMIC USE
   R06A ANTIHISTAMINES FOR SYSTEMIC USE
    R06AB Substituted alkylamines
     R06AB02 Dexchlorpheniramine
      D07803  Dexchlorpheniramine (INN)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Histamine
    HRH1
     D07803  Dexchlorpheniramine (INN)
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D07803
Other DBs
CAS: 25523-97-1
PubChem: 96024500
ChEBI: 4464
ChEMBL: CHEMBL1201353
DrugBank: DB01114
LigandBox: D07803
NIKKAJI: J19.804H
LinkDB
KCF data

ATOM        19
            1   C8x C    15.4000  -34.3000
            2   C8y C    15.4000  -35.7000
            3   C8x C    16.6124  -36.4000
            4   C8x C    17.8249  -35.7000
            5   C8y C    17.8249  -34.3000
            6   C8x C    16.6124  -33.6000
            7   C1c C    19.0560  -33.5890
            8   C8y C    20.2612  -34.2847
            9   C8x C    20.2616  -35.6996
            10  C8x C    21.4742  -36.3993
            11  C8x C    22.6865  -35.6989
            12  C8x C    22.6860  -34.2839
            13  N5x N    21.4734  -33.5843
            14  X   Cl   14.1876  -36.4000
            15  C1b C    19.0557  -32.2001
            16  C1b C    20.2562  -31.5066
            17  N1c N    20.2561  -30.1002
            18  C1a C    19.0241  -29.3888
            19  C1a C    21.4489  -29.4113
BOND        20
            1     1   2 2
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 2
            6     1   6 1
            7     5   7 1
            8     7   8 1
            9     8   9 2
            10    9  10 1
            11   10  11 2
            12   11  12 1
            13   12  13 2
            14    8  13 1
            15    2  14 1
            16    7  15 1 #Down
            17   15  16 1
            18   16  17 1
            19   17  18 1
            20   17  19 1

» Japanese version   » Back

KEGG   DRUG: Chlorpheniramine maleate
Entry
D00665                      Drug                                   

Name
Chlorpheniramine maleate (JP18/USP);
Chlor-trimeton (TN);
Teldrin (TN)
Formula
C16H19ClN2. C4H4O4
Exact mass
390.1346
Mol weight
390.8606
Structure
Simcomp
Class
Anti-allergic agent
 DG01557  Histamine receptor antagonist
  DG01482  Histamine receptor H1 antagonist
Remark
Same as: C07780
Therapeutic category: 4419
ATC code: R06AB04
Chemical structure group: DG01099
Product (DG01099): D00665<JP>
Product (mixture): D04044<JP> D04296<JP> D04313<JP> D11075<US>
Efficacy
Antiallergic, H1 receptor antagonist
Target
HRH1 [HSA:3269] [KO:K04149]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04750  Inflammatory mediator regulation of TRP channels
Interaction
Structure map
map07212  Histamine H1 receptor antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 R RESPIRATORY SYSTEM
  R06 ANTIHISTAMINES FOR SYSTEMIC USE
   R06A ANTIHISTAMINES FOR SYSTEMIC USE
    R06AB Substituted alkylamines
     R06AB04 Chlorphenamine
      D00665  Chlorpheniramine maleate (JP18/USP) <JP>
Therapeutic category of drugs in Japan [BR:br08301]
 4  Agents affecting cellular function
  44  Allergic agents
   441  Antihistamines
    4419  Others
     D00665  Chlorpheniramine maleate (JP18/USP)
Classification of Japanese OTC drugs [BR:br08313]
 Agents for nervous and sensory systems
  01 Cold remedy (oral use)
   D00665  Chlorpheniramine maleate (JP18/USP)
  06 Antivertigo drugs (incl. motion/morning sickness remedies)
   D00665  Chlorpheniramine maleate (JP18/USP)
 Agents for  urogenital organs and anus
  30 Hemorrhoid drugs for external use
   D00665  Chlorpheniramine maleate (JP18/USP)
 Allergic agents
  52 Antihistamine based drugs
   D00665  Chlorpheniramine maleate (JP18/USP)
 Agents for integumentary system
  57 Analgesic, antipruritic, astringent, and anti-inflammatory remedies (incl. gel patches)
   D00665  Chlorpheniramine maleate (JP18/USP)
 Agents for ophthalmologic use
  64 Allergy eye drops
   D00665  Chlorpheniramine maleate (JP18/USP)
  67 Eyewash
   D00665  Chlorpheniramine maleate (JP18/USP)
 Agents for otolaryngologic use
  69 Oral medicine for nasal inflammation
   D00665  Chlorpheniramine maleate (JP18/USP)
  70 Nasal sprays for inflammation
   D00665  Chlorpheniramine maleate (JP18/USP)
Risk category of Japanese OTC drugs [BR:br08312]
 Second-class OTC drugs
  Inorganic and organic chemicals
   Chlorphenamine
    D00665  Chlorpheniramine maleate (JP18/USP)
 Third-class OTC drugs
  Inorganic and organic chemicals
   Chlorphenamine
    D00665  Chlorpheniramine maleate (JP18/USP)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Histamine
    HRH1
     D00665  Chlorpheniramine maleate (JP18/USP) <JP>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D00665  Chlorpheniramine maleate
  D00665  Chlorpheniramine maleate tablets
  D00665  Chlorpheniramine maleate powder
  D00665  Chlorpheniramine maleate injection
Rx-to-OTC switch list in the USA [br08315.html]
 D00665
Other DBs
CAS: 113-92-8
PubChem: 7847731
ChEBI: 3645
ChEMBL: CHEMBL1659
DrugBank: DB01114
LigandBox: D00665
NIKKAJI: J237.304A
LinkDB
KCF data

ATOM        27
            1   C2b C    19.2774  -11.8495
            2   C2b C    17.7264  -11.8554
            3   C6a C    19.9250  -12.9665
            4   C6a C    17.0845  -12.9784
            5   O6a O    19.2832  -14.0898
            6   O6a O    21.2204  -12.9607
            7   O6a O    15.7890  -12.9784
            8   O6a O    17.7381  -14.0956
            9   C8x C     7.0000  -14.8400
            10  C8y C     7.0000  -16.2400
            11  C8x C     8.2124  -16.9400
            12  C8x C     9.4249  -16.2400
            13  C8y C     9.4249  -14.8400
            14  C8x C     8.2124  -14.1400
            15  C8x C    11.8497  -16.2400
            16  C8y C    11.8497  -14.8400
            17  C1c C    10.6373  -14.1400
            18  C8x C    13.0622  -16.9400
            19  C8x C    14.2746  -16.2400
            20  C8x C    14.2746  -14.8400
            21  N5x N    13.0622  -14.1400
            22  X   Cl    5.7876  -16.9400
            23  C1b C    10.6373  -12.7400
            24  C1b C    11.8518  -12.0388
            25  N1c N    11.8518  -10.6402
            26  C1a C    13.0479   -9.9495
            27  C1a C    10.6230   -9.9306
BOND        27
            1     1   2 2
            2     1   3 1
            3     2   4 1
            4     3   5 1
            5     3   6 2
            6     4   7 1
            7     4   8 2
            8     9  10 2
            9    10  11 1
            10   11  12 2
            11   12  13 1
            12   13  14 2
            13    9  14 1
            14   15  16 1
            15   16  17 1
            16   13  17 1
            17   15  18 2
            18   18  19 1
            19   19  20 2
            20   20  21 1
            21   16  21 2
            22   10  22 1
            23   17  23 1
            24   23  24 1
            25   24  25 1
            26   25  26 1
            27   25  27 1

» Japanese version   » Back

KEGG   DRUG: Dexchlorpheniramine maleate
Entry
D00668                      Drug                                   

Name
Dexchlorpheniramine maleate (USP);
d-Chlorpheniramine maleate (JP18);
Mylaramine (TN);
Polaramine (TN)
Product
  Generic
Formula
C16H19ClN2. C4H4O4
Exact mass
390.1346
Mol weight
390.8606
Structure
Simcomp
Class
Anti-allergic agent
 DG01557  Histamine receptor antagonist
  DG01482  Histamine receptor H1 antagonist
Metabolizing enzyme substrate
 DG01644  CYP2D6 substrate
 DG01633  CYP3A substrate
Metabolizing enzyme inhibitor
 DG01645  CYP2D6 inhibitor
Remark
Same as: C07783
Therapeutic category: 4419
ATC code: R06AB02
Chemical structure group: DG01098
Product (DG01098): D00668<JP/US>
Product (mixture): D04447<JP>
Efficacy
Antiallergic, Antipruritic, H1 receptor antagonist
  Disease
Perennial and seasonal allergic rhinitis [DS:H01360]
Target
HRH1 [HSA:3269] [KO:K04149]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04750  Inflammatory mediator regulation of TRP channels
Metabolism
Enzyme: CYP2D6 [HSA:1565], CYP3A [HSA:1576 1577 1551]
Interaction
CYP inhibition: CYP2D6 [HSA:1565]
Structure map
map07212  Histamine H1 receptor antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 R RESPIRATORY SYSTEM
  R06 ANTIHISTAMINES FOR SYSTEMIC USE
   R06A ANTIHISTAMINES FOR SYSTEMIC USE
    R06AB Substituted alkylamines
     R06AB02 Dexchlorpheniramine
      D00668  Dexchlorpheniramine maleate (USP) <JP/US>
Therapeutic category of drugs in Japan [BR:br08301]
 4  Agents affecting cellular function
  44  Allergic agents
   441  Antihistamines
    4419  Others
     D00668  Dexchlorpheniramine maleate (USP); d-Chlorpheniramine maleate (JP18)
Classification of Japanese OTC drugs [BR:br08313]
 Agents for nervous and sensory systems
  01 Cold remedy (oral use)
   D00668  Dexchlorpheniramine maleate (USP)
  06 Antivertigo drugs (incl. motion/morning sickness remedies)
   D00668  Dexchlorpheniramine maleate (USP)
 Allergic agents
  52 Antihistamine based drugs
   D00668  Dexchlorpheniramine maleate (USP)
 Agents for otolaryngologic use
  69 Oral medicine for nasal inflammation
   D00668  Dexchlorpheniramine maleate (USP)
Risk category of Japanese OTC drugs [BR:br08312]
 Second-class OTC drugs
  Inorganic and organic chemicals
   Chlorphenamine
    D00668  Dexchlorpheniramine maleate (USP)
 Third-class OTC drugs
  Inorganic and organic chemicals
   Chlorphenamine
    D00668  Dexchlorpheniramine maleate (USP)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Histamine
    HRH1
     D00668  Dexchlorpheniramine maleate (USP) <JP/US>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D00668  d-Chlorpheniramine maleate
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D00668
Rx-to-OTC switch list in the USA [br08315.html]
 D00668
Other DBs
CAS: 2438-32-6
PubChem: 7847734
ChEBI: 4465
ChEMBL: CHEMBL1200927
DrugBank: DB01114
LigandBox: D00668
NIKKAJI: J366.554B
LinkDB
KCF data

ATOM        27
            1   C8x C    20.6148  -17.3864
            2   C8y C    20.6148  -18.7909
            3   C8x C    21.8313  -19.4932
            4   C8x C    23.0477  -18.7909
            5   C8y C    23.0477  -17.3864
            6   C8x C    21.8313  -16.6840
            7   C8x C    25.4806  -18.7909
            8   C8y C    25.4806  -17.3864
            9   C1c C    24.2641  -16.6840
            10  C8x C    26.6971  -19.4932
            11  C8x C    27.9134  -18.7909
            12  C8x C    27.9134  -17.3864
            13  N5x N    26.6971  -16.6840
            14  X   Cl   19.3984  -19.4932
            15  C1b C    24.2641  -15.2794
            16  C1b C    25.4827  -14.5758
            17  N1c N    25.4827  -13.1727
            18  C1a C    26.6827  -12.4797
            19  C1a C    24.2497  -12.4607
            20  C6a C    33.4389  -15.9340
            21  C2b C    32.7702  -14.7804
            22  O6a O    32.8450  -17.1623
            23  O6a O    34.7766  -15.9277
            24  C2b C    31.1688  -14.7865
            25  C6a C    30.5061  -15.9461
            26  O6a O    29.1684  -15.9461
            27  O6a O    31.1811  -17.1684
BOND        27
            1     1   2 2
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 2
            6     1   6 1
            7     7   8 1
            8     8   9 1
            9     5   9 1
            10    7  10 2
            11   10  11 1
            12   11  12 2
            13   12  13 1
            14    8  13 2
            15    2  14 1
            16    9  15 1 #Down
            17   15  16 1
            18   16  17 1
            19   17  18 1
            20   17  19 1
            21   20  21 1
            22   20  22 1
            23   20  23 2
            24   21  24 2
            25   24  25 1
            26   25  26 1
            27   25  27 2

» Japanese version   » Back

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