Entry |
|
Name |
Codeine phosphate and chlorpheniramine maleate; Tuxarin (TN) |
Product |
|
Component |
Codeine phosphate [DR: D02101], Chlorpheniramine maleate [DR: D00665]
|
Class |
|
Remark |
|
Efficacy |
Antitussive |
Comment |
Dihydrocodeine phosphate is metabolized by UGT2B7, UGT2B4 with some contribution from CYP3A4 and CYP2D6.
Chlorpheniramine is metabolized by CYP2D6.
|
Metabolism |
Enzyme: UGT2B7 [HSA: 7364], UGT2B4 [HSA: 7363]; CYP3A4 [HSA: 1576], CYP2D6 [HSA: 1565]
|
Interaction |
|
Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
R RESPIRATORY SYSTEM
R05 COUGH AND COLD PREPARATIONS
R05D COUGH SUPPRESSANTS, EXCL. COMBINATIONS WITH EXPECTORANTS
R05DA Opium alkaloids and derivatives
R05DA20 Combinations
D12312 Codeine phosphate and chlorpheniramine maleate <US>
USP drug classification [BR:br08302]
Respiratory Tract/Pulmonary Agents
Cold-Cough
Chlorpheniramine Maleate/ Codeine Phosphate
D12312 Codeine phosphate and chlorpheniramine maleate
Drug groups [BR:br08330]
Metabolizing enzyme substrate
DG01644 CYP2D6 substrate
D12312 Codeine phosphate and chlorpheniramine maleate
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
D12312 Codeine phosphate and chlorpheniramine maleate
DG02924 UGT substrate
DG03189 UGT2B4 substrate
D12312 Codeine phosphate and chlorpheniramine maleate
DG03190 UGT2B7 substrate
D12312 Codeine phosphate and chlorpheniramine maleate
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
D12312
|
Other DBs |
|
LinkDB |
|