| Entry |
|
|---|
| Name |
Amosulalol (INN) |
|---|
| Formula |
C18H24N2O5S
|
|---|
| Exact mass |
380.1406
|
|---|
| Mol weight |
380.46
|
|---|
| Structure |
|
|---|
| Simcomp |
|
|---|
| Class |
Cardiovascular agent
DG01466 Adrenergic receptor antagonist
DG03180 alpha1 and beta-Adrenergic receptor antagonist
DG03231 Antihypertensive
DG03180 alpha1 and beta-Adrenergic receptor antagonist
|
|---|
| Remark |
| Product (DG01302): | D01469<JP> |
|
|---|
| Efficacy |
Antihypertansive, alpha1/beta-Adrenergic receptor antagonist |
|---|
| Target |
|
|---|
| Pathway |
| hsa04080 | Neuroactive ligand-receptor interaction |
| hsa04261 | Adrenergic signaling in cardiomyocytes |
| hsa04270 | Vascular smooth muscle contraction |
|
|---|
| Interaction |
|
|---|
| Structure map |
| map07214 | beta-Adrenergic receptor agonists/antagonists |
| map07215 | alpha-Adrenergic receptor agonists/antagonists |
|
|---|
| Brite |
Drug groups [BR:br08330]
Cardiovascular agent
DG01466 Adrenergic receptor antagonist
DG03180 alpha1 and beta-Adrenergic receptor antagonist
DG01302 Amosulalol
D07451 Amosulalol
DG03231 Antihypertensive
DG03180 alpha1 and beta-Adrenergic receptor antagonist
DG01302 Amosulalol
D07451 Amosulalol
Target-based classification of drugs [BR:br08310]
G Protein-coupled receptors
Rhodopsin family
Adrenaline
ADRA1
D07451 Amosulalol (INN)
ADRB1
D07451 Amosulalol (INN)
ADRB2
D07451 Amosulalol (INN)
Drug groups [BR:br08330]
Cardiovascular agent
DG01466 Adrenergic receptor antagonist
DG03180 alpha1 and beta-Adrenergic receptor antagonist
DG01302 Amosulalol
DG03231 Antihypertensive
DG03180 alpha1 and beta-Adrenergic receptor antagonist
DG01302 Amosulalol
|
|---|
| Other DBs |
|
|---|
| LinkDB |
|
|---|
| KCF data |
ATOM 26
1 C8y C 18.1300 -17.5700
2 C8x C 18.1300 -18.9700
3 C8x C 19.3900 -19.6700
4 C8y C 20.5800 -18.9700
5 C8x C 20.5800 -17.5700
6 C8y C 19.3900 -16.8700
7 C1a C 16.9400 -16.8700
8 S4a S 19.3900 -15.4700
9 N1a N 19.3900 -14.0700
10 O3c O 17.9200 -15.4700
11 O3c O 20.7200 -15.4700
12 C1c C 21.8400 -19.6700
13 C1b C 23.0300 -18.9700
14 O1a O 21.8400 -21.0700
15 N1b N 24.2200 -19.6700
16 C1b C 25.4100 -18.9700
17 C1b C 26.6000 -19.6700
18 O2a O 27.7900 -18.9700
19 C8y C 28.9800 -19.6700
20 C8y C 28.9800 -21.0700
21 C8x C 30.2400 -21.7700
22 C8x C 31.4300 -21.0700
23 C8x C 31.4300 -19.6700
24 C8x C 30.2400 -18.9700
25 O2a O 27.7900 -21.8400
26 C1a C 26.5300 -21.1400
BOND 27
1 1 2 2
2 2 3 1
3 3 4 2
4 4 5 1
5 5 6 2
6 1 6 1
7 1 7 1
8 6 8 1
9 8 9 1
10 8 10 2
11 8 11 2
12 4 12 1
13 12 13 1
14 12 14 1
15 13 15 1
16 15 16 1
17 16 17 1
18 17 18 1
19 18 19 1
20 19 20 2
21 20 21 1
22 21 22 2
23 22 23 1
24 23 24 2
25 19 24 1
26 20 25 1
27 25 26 1
|
|---|
