KEGG   DRUG: ApraclonidineHelp
Entry
D07461                      Drug                                   

Name
Apraclonidine (INN);
Iopidine (TN)
Formula
C9H10Cl2N4
Exact mass
244.0283
Mol weight
245.1085
Structure
Mol fileKCF fileDB search
Simcomp SIMCOMP
Class
Cardiovascular agent
 DG01456  Adrenergic receptor agonist
  DG01450  alpha-Adrenergic receptor agonist
   DG01449  alpha2-Adrenergic receptor agonist
    DG01655  alpha2-adrenergic receptor specific agonist
Remark
Same as: C07668
ATC code: S01EA03
Chemical structure group: DG01130
Product (DG01130): D01008<JP/US>
Efficacy
Antiglaucoma, Antihypertensive (intraocular), alpha2-Adrenergic receptor agonist
Target
ADRA2 [HSA:150 151 152] [KO:K04138 K04139 K04140]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
Interaction
Drug interaction
Structure map
map07054  Antiglaucoma agents
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 S SENSORY ORGANS
  S01 OPHTHALMOLOGICALS
   S01E ANTIGLAUCOMA PREPARATIONS AND MIOTICS
    S01EA Sympathomimetics in glaucoma therapy
     S01EA03 Apraclonidine
      D07461  Apraclonidine (INN)
USP drug classification [BR:br08302]
 Ophthalmic Agents
  Ophthalmic Antiglaucoma Agents
   Apraclonidine
    D07461  Apraclonidine (INN)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Adrenaline
    ADRA2
     D07461  Apraclonidine (INN)
BRITE hierarchy
Other DBs
CAS: 66711-21-5
PubChem: 51091792
ChEBI: 2788
ChEMBL: CHEMBL647
DrugBank: DB00964
LigandBox: D07461
NIKKAJI: J247.956G
LinkDB All DBs
KCF data Show

ATOM        15
            1   C8x C    18.1300  -16.7300
            2   C8y C    18.1300  -18.1300
            3   C8x C    19.3200  -18.8300
            4   C8y C    20.5800  -18.1300
            5   C8y C    20.5800  -16.7300
            6   C8y C    19.3200  -16.0300
            7   X   Cl   21.7700  -18.8300
            8   N2x N    22.9600  -18.1300
            9   C2y C    22.9600  -16.7300
            10  N1b N    21.7700  -16.0300
            11  C1x C    24.2900  -18.5500
            12  C1x C    25.1300  -17.4300
            13  N1x N    24.2900  -16.3100
            14  X   Cl   19.3200  -14.6300
            15  N1a N    16.9400  -18.8300
BOND        16
            1     1   2 2
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 2
            6     1   6 1
            7     4   7 1
            8     8   9 2
            9     9  10 1
            10    5  10 1
            11    8  11 1
            12   11  12 1
            13   12  13 1
            14    9  13 1
            15    6  14 1
            16    2  15 1

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