| Entry |
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| Name |
Dexamethasone 21-valerate;
Voalla (TN);
Zalucs (TN) |
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| Formula |
C27H37FO6
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| Exact mass |
476.2574
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| Mol weight |
476.58
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| Structure |
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| Simcomp |
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| Class |
Anti-inflammatory
DG01955 Corticosteroid
DG02068 Glucocorticoid
Metabolizing enzyme substrate
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
Metabolizing enzyme inducer
DG02853 CYP3A/CYP3A4 inducer
DG01635 CYP3A4 inducer
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| Remark |
| Product (DG00011): | D00292<JP/US> D00975<JP/US> D01510<JP> D01615<JP> D01632<JP> D01948<JP> D07073<JP> |
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| Efficacy |
Anti-inflammatory, Glucocorticoid receptor agonist |
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| Target |
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| Pathway |
| hsa04080 | Neuroactive ligand-receptor interaction |
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| Metabolism |
Enzyme: CYP3A4 [HSA: 1576]
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| Interaction |
CYP induction: CYP3A4 [HSA: 1576]
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| Structure map |
| map07225 | Glucocorticoid and mineralocorticoid receptor agonists/antagonists |
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| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
A ALIMENTARY TRACT AND METABOLISM
A01 STOMATOLOGICAL PREPARATIONS
A01A STOMATOLOGICAL PREPARATIONS
A01AC Corticosteroids for local oral treatment
A01AC02 Dexamethasone
D07800 Dexamethasone 21-valerate
C CARDIOVASCULAR SYSTEM
C05 VASOPROTECTIVES
C05A AGENTS FOR TREATMENT OF HEMORRHOIDS AND ANAL FISSURES FOR TOPICAL USE
C05AA Corticosteroids
C05AA09 Dexamethasone
D07800 Dexamethasone 21-valerate
D DERMATOLOGICALS
D07 CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS
D07A CORTICOSTEROIDS, PLAIN
D07AB Corticosteroids, moderately potent (group II)
D07AB19 Dexamethasone
D07800 Dexamethasone 21-valerate
D07X CORTICOSTEROIDS, OTHER COMBINATIONS
D07XB Corticosteroids, moderately potent, other combinations
D07XB05 Dexamethasone
D07800 Dexamethasone 21-valerate
D10 ANTI-ACNE PREPARATIONS
D10A ANTI-ACNE PREPARATIONS FOR TOPICAL USE
D10AA Corticosteroids, combinations for treatment of acne
D10AA03 Dexamethasone
D07800 Dexamethasone 21-valerate
H SYSTEMIC HORMONAL PREPARATIONS, EXCL. SEX HORMONES AND INSULINS
H02 CORTICOSTEROIDS FOR SYSTEMIC USE
H02A CORTICOSTEROIDS FOR SYSTEMIC USE, PLAIN
H02AB Glucocorticoids
H02AB02 Dexamethasone
D07800 Dexamethasone 21-valerate
R RESPIRATORY SYSTEM
R01 NASAL PREPARATIONS
R01A DECONGESTANTS AND OTHER NASAL PREPARATIONS FOR TOPICAL USE
R01AD Corticosteroids
R01AD03 Dexamethasone
D07800 Dexamethasone 21-valerate
S SENSORY ORGANS
S01 OPHTHALMOLOGICALS
S01B ANTIINFLAMMATORY AGENTS
S01BA Corticosteroids, plain
S01BA01 Dexamethasone
D07800 Dexamethasone 21-valerate
S01C ANTIINFLAMMATORY AGENTS AND ANTIINFECTIVES IN COMBINATION
S01CB Corticosteroids/antiinfectives/mydriatics in combination
S01CB01 Dexamethasone
D07800 Dexamethasone 21-valerate
S02 OTOLOGICALS
S02B CORTICOSTEROIDS
S02BA Corticosteroids
S02BA06 Dexamethasone
D07800 Dexamethasone 21-valerate
S03 OPHTHALMOLOGICAL AND OTOLOGICAL PREPARATIONS
S03B CORTICOSTEROIDS
S03BA Corticosteroids
S03BA01 Dexamethasone
D07800 Dexamethasone 21-valerate
Drug groups [BR:br08330]
Anti-inflammatory
DG01955 Corticosteroid
DG02068 Glucocorticoid
DG00011 Dexamethasone
D07800 Dexamethasone 21-valerate
Metabolizing enzyme substrate
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
DG00011 Dexamethasone
D07800 Dexamethasone 21-valerate
Metabolizing enzyme inducer
DG02853 CYP3A/CYP3A4 inducer
DG01635 CYP3A4 inducer
DG00011 Dexamethasone
D07800 Dexamethasone 21-valerate
Target-based classification of drugs [BR:br08310]
Nuclear receptors
Estrogen like receptors
3-Ketosteroid receptor
NR3C1 (GR)
D07800 Dexamethasone 21-valerate
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
D07800
Drug groups [BR:br08330]
Anti-inflammatory
DG01955 Corticosteroid
DG02068 Glucocorticoid
DG00011 Dexamethasone
Metabolizing enzyme substrate
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
DG00011 Dexamethasone
Metabolizing enzyme inducer
DG02853 CYP3A/CYP3A4 inducer
DG01635 CYP3A4 inducer
DG00011 Dexamethasone
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| Other DBs |
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| LinkDB |
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| KCF data |
ATOM 34
1 C2x C 7.7000 -22.4000
2 C5x C 7.7000 -23.7300
3 C2x C 8.8900 -24.4300
4 C2y C 10.0800 -23.7300
5 C1z C 10.0800 -22.4000
6 C2x C 8.8900 -21.7700
7 C1x C 11.2000 -24.4300
8 C1x C 12.3900 -23.7300
9 C1y C 12.3900 -22.4000
10 C1z C 11.2000 -21.7700
11 C1y C 13.5800 -21.7700
12 C1z C 13.5800 -20.3700
13 C1x C 12.3900 -19.7400
14 C1y C 11.2000 -20.3700
15 C1x C 15.9600 -21.7700
16 C1y C 15.9600 -20.3700
17 C1z C 14.7700 -19.7400
18 O1a O 15.7500 -18.7600
19 X F 11.2000 -23.0300
20 O5x O 6.5800 -24.4300
21 C1a C 13.5800 -19.0400
22 C1a C 10.0800 -21.0700
23 O1a O 10.2900 -19.4600
24 C1a C 17.3600 -19.8100
25 C5a C 14.7700 -17.9200
26 O5a O 13.5800 -17.2200
27 C1b C 15.9853 -17.2249
28 O7a O 17.1737 -17.9177
29 C7a C 18.3701 -17.2335
30 C1b C 19.5513 -17.9219
31 O6a O 18.3156 -15.8202
32 C1b C 20.7513 -17.2355
33 C1b C 21.9308 -17.9229
34 C1a C 23.1315 -17.2359
BOND 37
1 1 2 1
2 2 3 1
3 3 4 2
4 4 5 1
5 5 6 1
6 1 6 2
7 4 7 1
8 7 8 1
9 8 9 1
10 9 10 1
11 5 10 1
12 9 11 1
13 11 12 1
14 12 13 1
15 13 14 1
16 10 14 1
17 15 16 1
18 16 17 1
19 12 17 1
20 17 18 1 #Down
21 10 19 1 #Down
22 2 20 2
23 11 15 1
24 12 21 1 #Up
25 5 22 1 #Up
26 14 23 1 #Up
27 16 24 1 #Down
28 25 26 2
29 17 25 1 #Up
30 25 27 1
31 27 28 1
32 28 29 1
33 29 30 1
34 29 31 2
35 30 32 1
36 32 33 1
37 33 34 1
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