| Entry |
|
|---|
| Name |
Dihydrocodeine (INN);
Remedacen (TN) |
|---|
| Formula |
C18H23NO3
|
|---|
| Exact mass |
301.1678
|
|---|
| Mol weight |
301.38
|
|---|
| Structure |
|
|---|
| Simcomp |
|
|---|
| Class |
|
|---|
| Remark |
| Product (DG00814): | D01481<JP> |
|
|---|
| Efficacy |
Analgesic (narcotic), Antitussive, Opioid receptor agonist |
|---|
| Comment |
Opium alkaloid
|
|---|
| Target |
|
|---|
| Pathway |
| hsa04080 | Neuroactive ligand-receptor interaction |
|
|---|
| Metabolism |
Enzyme: UGT2B7 [HSA: 7364], UGT2B4 [HSA: 7363]; CYP3A4 [HSA: 1576], CYP2D6 [HSA: 1565]
|
|---|
| Interaction |
|
|---|
| Structure map |
| map07224 | Opioid receptor agonists/antagonists |
|
|---|
| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
N NERVOUS SYSTEM
N02 ANALGESICS
N02A OPIOIDS
N02AA Natural opium alkaloids
N02AA08 Dihydrocodeine
D07831 Dihydrocodeine (INN)
Risk category of Japanese OTC drugs [BR:br08312]
Designated second-class OTC drugs
Inorganic and organic chemicals
Dihydrocodeine
D07831 Dihydrocodeine (INN)
Second-class OTC drugs
Inorganic and organic chemicals
Dihydrocodeine
D07831 Dihydrocodeine (INN)
Drug groups [BR:br08330]
Neuropsychiatric agent
DG01564 Opioid receptor agonist
DG01563 mu-Opioid receptor agonist
DG00814 Dihydrocodeine
D07831 Dihydrocodeine
Analgesic
DG01984 Opioid analgesics
DG00814 Dihydrocodeine
D07831 Dihydrocodeine
Metabolizing enzyme substrate
DG01644 CYP2D6 substrate
DG00814 Dihydrocodeine
D07831 Dihydrocodeine
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
DG00814 Dihydrocodeine
D07831 Dihydrocodeine
DG02924 UGT substrate
DG03189 UGT2B4 substrate
DG00814 Dihydrocodeine
D07831 Dihydrocodeine
DG03190 UGT2B7 substrate
DG00814 Dihydrocodeine
D07831 Dihydrocodeine
Target-based classification of drugs [BR:br08310]
G Protein-coupled receptors
Rhodopsin family
Opioid
OPRM1
D07831 Dihydrocodeine (INN)
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
D07831
Narcotics and psychotropics in Japan [br08308.html]
Narcotics by Control Act Article 2 Table 1 (74 substances)
D07831
Drug groups [BR:br08330]
Neuropsychiatric agent
DG01564 Opioid receptor agonist
DG01563 mu-Opioid receptor agonist
DG00814 Dihydrocodeine
Analgesic
DG01984 Opioid analgesics
DG00814 Dihydrocodeine
Metabolizing enzyme substrate
DG01644 CYP2D6 substrate
DG00814 Dihydrocodeine
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
DG00814 Dihydrocodeine
DG02924 UGT substrate
DG03189 UGT2B4 substrate
DG00814 Dihydrocodeine
DG03190 UGT2B7 substrate
DG00814 Dihydrocodeine
|
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| Other DBs |
|
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| LinkDB |
|
|---|
| KCF data |
ATOM 22
1 C1z C 23.5200 -18.5500
2 C8y C 23.5200 -17.2900
3 C1y C 24.6400 -19.2500
4 C1y C 22.4000 -19.2500
5 C1x C 24.4300 -17.6400
6 C8y C 22.4000 -16.6600
7 C8y C 24.6400 -16.6600
8 C1y C 25.7600 -18.6200
9 C1x C 24.6400 -20.5100
10 O2x O 21.1400 -17.9200
11 C1y C 22.4000 -20.5100
12 C1x C 26.8800 -17.6400
13 C8y C 22.4000 -15.3300
14 C1x C 25.7600 -17.2900
15 C8x C 24.6400 -15.3300
16 N1y N 26.8800 -19.2500
17 C1x C 23.5200 -21.2100
18 C8x C 23.5200 -14.7000
19 O2a O 21.2800 -14.7000
20 O1a O 21.2800 -21.2100
21 C1a C 20.0900 -15.4000
22 C1a C 28.2800 -19.2500
BOND 26
1 4 10 1 #Down
2 4 11 1
3 5 12 1
4 6 13 2
5 7 14 1
6 7 15 1
7 8 16 1 #Up
8 9 17 1
9 13 18 1
10 13 19 1
11 6 10 1
12 8 14 1
13 11 17 1
14 12 16 1
15 15 18 2
16 11 20 1 #Down
17 1 2 1
18 1 3 1
19 1 4 1
20 1 5 1 #Up
21 2 6 1
22 2 7 2
23 3 8 1
24 3 9 1
25 19 21 1
26 16 22 1
|
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