| Entry |
|
|---|
| Name |
Donepezil (JAN/INN);
Donaz (TN);
Allydone (TN) |
|---|
| Formula |
C24H29NO3
|
|---|
| Exact mass |
379.2147
|
|---|
| Mol weight |
379.49
|
|---|
| Structure |
|
|---|
| Simcomp |
|
|---|
| Class |
Neuropsychiatric agent
DG01595 Cholinesterase inhibitor
DG01593 Acetylcholinesterase inhibitor
DG01968 Antidementia agent
Metabolizing enzyme substrate
DG01644 CYP2D6 substrate
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
|
|---|
| Remark |
| Therapeutic category: | 1190 |
| Product (DG00983): | D07869<JP> D00670<JP/US> |
| Product (mixture): | D11387<US> |
|
|---|
| Efficacy |
Dementia therapeutic agent, Acetylcholinesterase inhibitor |
|---|
| Target |
|
|---|
| Pathway |
|
|---|
| Metabolism |
Enzyme: CYP3A4 [HSA: 1576]; CYP2D6 [HSA: 1565]
|
|---|
| Interaction |
|
|---|
| Structure map |
| map07056 | Agents for Alzheimer-type dementia |
| map07220 | Cholinergic and anticholinergic drugs |
|
|---|
| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
N NERVOUS SYSTEM
N06 PSYCHOANALEPTICS
N06D ANTI-DEMENTIA DRUGS
N06DA Anticholinesterases
N06DA02 Donepezil
D07869 Donepezil (JAN/INN) <JP>
Therapeutic category of drugs in Japan [BR:br08301]
1 Agents affecting nervous system and sensory organs
11 Agents affecting central nervous system
119 Miscellaneous
1190 Miscellaneous
D07869 Donepezil (JAN/INN)
Drug groups [BR:br08330]
Neuropsychiatric agent
DG01595 Cholinesterase inhibitor
DG01593 Acetylcholinesterase inhibitor
DG00983 Donepezil
D07869 Donepezil
DG01968 Antidementia agent
DG00983 Donepezil
D07869 Donepezil
Metabolizing enzyme substrate
DG01644 CYP2D6 substrate
DG00983 Donepezil
D07869 Donepezil
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
DG00983 Donepezil
D07869 Donepezil
Drug classes [BR:br08332]
Neuropsychiatric agent
DG01968 Antidementia agent
D07869 Donepezil
Target-based classification of drugs [BR:br08310]
Enzymes
Hydrolases (EC3)
Carboxylic-ester hydrolases
ACHE
D07869 Donepezil (JAN/INN) <JP>
New drug approvals in Japan [br08318.html]
Drugs with new active ingredients
D07869
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
D07869
Drug groups [BR:br08330]
Neuropsychiatric agent
DG01595 Cholinesterase inhibitor
DG01593 Acetylcholinesterase inhibitor
DG00983 Donepezil
DG01968 Antidementia agent
DG00983 Donepezil
Metabolizing enzyme substrate
DG01644 CYP2D6 substrate
DG00983 Donepezil
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
DG00983 Donepezil
|
|---|
| Other DBs |
|
|---|
| LinkDB |
|
|---|
| KCF data |
ATOM 28
1 C8y C 26.5300 -17.3600
2 C8x C 26.5300 -18.7600
3 C8x C 27.7200 -19.4600
4 C8x C 28.9100 -18.7600
5 C8x C 28.9100 -17.3600
6 C8x C 27.7200 -16.6600
7 C1b C 25.2700 -16.6600
8 N1y N 24.0800 -17.3600
9 C1x C 22.8900 -16.6600
10 C1x C 21.7000 -17.3600
11 C1y C 21.7000 -18.7600
12 C1x C 22.8900 -19.4600
13 C1x C 24.0800 -18.7600
14 C1b C 20.4400 -19.4600
15 C1y C 19.2500 -18.7600
16 C5x C 19.2500 -17.3600
17 C8y C 17.9900 -16.8700
18 C8y C 17.0800 -17.9900
19 C1x C 17.9200 -19.1800
20 O5x O 20.4400 -16.5900
21 C8x C 17.4300 -15.5400
22 C8y C 16.0300 -15.3300
23 C8y C 15.1900 -16.4500
24 C8x C 15.6800 -17.7800
25 O2a O 15.5400 -14.0700
26 C1a C 14.2100 -14.0700
27 O2a O 13.8600 -16.4500
28 C1a C 13.0900 -15.2600
BOND 31
1 1 2 2
2 2 3 1
3 3 4 2
4 4 5 1
5 5 6 2
6 1 6 1
7 1 7 1
8 7 8 1
9 8 9 1
10 9 10 1
11 10 11 1
12 11 12 1
13 12 13 1
14 8 13 1
15 11 14 1
16 14 15 1
17 15 16 1
18 16 17 1
19 17 18 1
20 18 19 1
21 15 19 1
22 16 20 2
23 17 21 2
24 21 22 1
25 22 23 2
26 23 24 1
27 18 24 2
28 22 25 1
29 25 26 1
30 23 27 1
31 27 28 1
|
|---|
