KEGG   DRUG: Losartan potassium and hydrochlorothiazide
Entry
D07895            Mixture   Drug                                   
Name
Losartan potassium and hydrochlorothiazide (JP18);
Hydrochlorothiazide and losartan potassium;
Hyzaar (TN);
Losarhyd (TN)
Product
  Generic
LOSARTAN POT/HCTZ (Direct_Rx), LOSARTAN POTASSIUM AND HYDROCHLOROTHIAZIDE (A-S Medication Solutions), LOSARTAN POTASSIUM AND HYDROCHLOROTHIAZIDE (A-S Medication Solutions), LOSARTAN POTASSIUM AND HYDROCHLOROTHIAZIDE (A-S Medication Solutions), LOSARTAN POTASSIUM AND HYDROCHLOROTHIAZIDE (A-S Medication Solutions), LOSARTAN POTASSIUM AND HYDROCHLOROTHIAZIDE (A-S Medication Solutions), LOSARTAN POTASSIUM AND HYDROCHLOROTHIAZIDE (A-S Medication Solutions), LOSARTAN POTASSIUM AND HYDROCHLOROTHIAZIDE (A-S Medication Solutions), LOSARTAN POTASSIUM AND HYDROCHLOROTHIAZIDE (A-S Medication Solutions), LOSARTAN POTASSIUM AND HYDROCHLOROTHIAZIDE (A-S Medication Solutions), LOSARTAN POTASSIUM AND HYDROCHLOROTHIAZIDE (A-S Medication Solutions), LOSARTAN POTASSIUM AND HYDROCHLOROTHIAZIDE (A-S Medication Solutions), LOSARTAN POTASSIUM AND HYDROCHLOROTHIAZIDE (A-S Medication Solutions), LOSARTAN POTASSIUM AND HYDROCHLOROTHIAZIDE (ACETRIS HEALTH), LOSARTAN POTASSIUM AND HYDROCHLOROTHIAZIDE (Alembic Pharmaceuticals), LOSARTAN POTASSIUM AND HYDROCHLOROTHIAZIDE (Alembic Pharmaceuticals Limited), LOSARTAN POTASSIUM AND HYDROCHLOROTHIAZIDE (Aurobindo Pharma Limited), LOSARTAN POTASSIUM AND HYDROCHLOROTHIAZIDE (Bryant Ranch Prepack), LOSARTAN POTASSIUM AND HYDROCHLOROTHIAZIDE (Bryant Ranch Prepack), LOSARTAN POTASSIUM AND HYDROCHLOROTHIAZIDE (Bryant Ranch Prepack), LOSARTAN POTASSIUM AND HYDROCHLOROTHIAZIDE (Bryant Ranch Prepack), LOSARTAN POTASSIUM AND HYDROCHLOROTHIAZIDE (Bryant Ranch Prepack), LOSARTAN POTASSIUM AND HYDROCHLOROTHIAZIDE (Bryant Ranch Prepack), LOSARTAN POTASSIUM AND HYDROCHLOROTHIAZIDE (Bryant Ranch Prepack), LOSARTAN POTASSIUM AND HYDROCHLOROTHIAZIDE (Bryant Ranch Prepack), LOSARTAN POTASSIUM AND HYDROCHLOROTHIAZIDE (Cadila Healthcare Limited), LOSARTAN POTASSIUM AND HYDROCHLOROTHIAZIDE (DIRECT RX), LOSARTAN POTASSIUM AND HYDROCHLOROTHIAZIDE (Direct Rx), LOSARTAN POTASSIUM AND HYDROCHLOROTHIAZIDE (Direct Rx), LOSARTAN POTASSIUM AND HYDROCHLOROTHIAZIDE (Direct Rx), LOSARTAN POTASSIUM AND HYDROCHLOROTHIAZIDE (Direct Rx), LOSARTAN POTASSIUM AND HYDROCHLOROTHIAZIDE (DirectRx), LOSARTAN POTASSIUM AND HYDROCHLOROTHIAZIDE (DirectRx), LOSARTAN POTASSIUM AND HYDROCHLOROTHIAZIDE (DirectRx), LOSARTAN POTASSIUM AND HYDROCHLOROTHIAZIDE (DirectRx), LOSARTAN POTASSIUM AND HYDROCHLOROTHIAZIDE (Direct_Rx), LOSARTAN POTASSIUM AND HYDROCHLOROTHIAZIDE (JUBILANT CADISTA PHARMACEUTICALS), LOSARTAN POTASSIUM AND HYDROCHLOROTHIAZIDE (Lupin Pharmaceuticals), LOSARTAN POTASSIUM AND HYDROCHLOROTHIAZIDE (Macleods Pharmaceuticals Limited), LOSARTAN POTASSIUM AND HYDROCHLOROTHIAZIDE (NorthStar Rx LLC), LOSARTAN POTASSIUM AND HYDROCHLOROTHIAZIDE (NuCare Pharmaceutiacals), LOSARTAN POTASSIUM AND HYDROCHLOROTHIAZIDE (NuCare Pharmaceuticals), LOSARTAN POTASSIUM AND HYDROCHLOROTHIAZIDE (NuCare Pharmaceuticals), LOSARTAN POTASSIUM AND HYDROCHLOROTHIAZIDE (NuCare Pharmaceuticals), LOSARTAN POTASSIUM AND HYDROCHLOROTHIAZIDE (NuCare Pharmaceuticals), LOSARTAN POTASSIUM AND HYDROCHLOROTHIAZIDE (NuCare Pharmaceuticals), LOSARTAN POTASSIUM AND HYDROCHLOROTHIAZIDE (NuCare Pharmaceuticals), LOSARTAN POTASSIUM AND HYDROCHLOROTHIAZIDE (NuCare Pharmaceuticals), LOSARTAN POTASSIUM AND HYDROCHLOROTHIAZIDE (NuCare Pharmaceuticals), LOSARTAN POTASSIUM AND HYDROCHLOROTHIAZIDE (NuCare Pharmaceuticals), LOSARTAN POTASSIUM AND HYDROCHLOROTHIAZIDE (NuCare Pharmaceuticals), LOSARTAN POTASSIUM AND HYDROCHLOROTHIAZIDE (NuCare Pharmaceuticals), LOSARTAN POTASSIUM AND HYDROCHLOROTHIAZIDE (PD-Rx Pharmaceuticals), LOSARTAN POTASSIUM AND HYDROCHLOROTHIAZIDE (PD-Rx Pharmaceuticals), LOSARTAN POTASSIUM AND HYDROCHLOROTHIAZIDE (PD-Rx Pharmaceuticals), LOSARTAN POTASSIUM AND HYDROCHLOROTHIAZIDE (Preferred Pharmaceuticals), LOSARTAN POTASSIUM AND HYDROCHLOROTHIAZIDE (Preferred Pharmaceuticals), LOSARTAN POTASSIUM AND HYDROCHLOROTHIAZIDE (Preferred Pharmaceuticals), LOSARTAN POTASSIUM AND HYDROCHLOROTHIAZIDE (Preferred Pharmaceuticals), LOSARTAN POTASSIUM AND HYDROCHLOROTHIAZIDE (Proficient Rx LP), LOSARTAN POTASSIUM AND HYDROCHLOROTHIAZIDE (Proficient Rx LP), LOSARTAN POTASSIUM AND HYDROCHLOROTHIAZIDE (Proficient Rx LP), LOSARTAN POTASSIUM AND HYDROCHLOROTHIAZIDE (Proficient Rx LP), LOSARTAN POTASSIUM AND HYDROCHLOROTHIAZIDE (Proficient Rx LP), LOSARTAN POTASSIUM AND HYDROCHLOROTHIAZIDE (Proficient Rx LP), LOSARTAN POTASSIUM AND HYDROCHLOROTHIAZIDE (Proficient Rx LP), LOSARTAN POTASSIUM AND HYDROCHLOROTHIAZIDE (Proficient Rx LP), LOSARTAN POTASSIUM AND HYDROCHLOROTHIAZIDE (QPharma), LOSARTAN POTASSIUM AND HYDROCHLOROTHIAZIDE (REMEDYREPACK), LOSARTAN POTASSIUM AND HYDROCHLOROTHIAZIDE (REMEDYREPACK), LOSARTAN POTASSIUM AND HYDROCHLOROTHIAZIDE (REMEDYREPACK), LOSARTAN POTASSIUM AND HYDROCHLOROTHIAZIDE (REMEDYREPACK), LOSARTAN POTASSIUM AND HYDROCHLOROTHIAZIDE (REMEDYREPACK), LOSARTAN POTASSIUM AND HYDROCHLOROTHIAZIDE (REMEDYREPACK), LOSARTAN POTASSIUM AND HYDROCHLOROTHIAZIDE (REMEDYREPACK), LOSARTAN POTASSIUM AND HYDROCHLOROTHIAZIDE (Rising Health), LOSARTAN POTASSIUM AND HYDROCHLOROTHIAZIDE (Solco Healthcare US), LOSARTAN POTASSIUM AND HYDROCHLOROTHIAZIDE (St. Marys Medical Park Pharmacy), LOSARTAN POTASSIUM AND HYDROCHLOROTHIAZIDE (Teva Pharmaceuticals USA), LOSARTAN POTASSIUM AND HYDROCHLOROTHIAZIDE (Torrent Pharmaceuticals Limited), LOSARTAN POTASSIUM AND HYDROCHLOROTHIAZIDE (Unichem Pharmaceuticals (USA)), LOSARTAN POTASSIUM AND HYDROCHLOROTHIAZIDE (Zydus Pharmaceuticals (USA)), LOSARTAN POTASSIUM HCTZ (DIRECT RX)
Component
Hydrochlorothiazide [DR:D00340], Losartan potassium [DR:D00357]
Class
Cardiovascular agent
 DG01925  Renin-angiotensin system inhibitor
Metabolizing enzyme substrate
 DG01642  CYP2C9 substrate
Remark
Therapeutic category: 2149
ATC code: C09DA01
Product: D07895<JP/US>
Efficacy
Antihypertensive
  Disease
Hypertension [DS:H01633]
Comment
Losartan potassium is primarily metabolized by CYP2C9.
Metabolism
Enzyme: CYP2C9 [HSA:1559]
Interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 C CARDIOVASCULAR SYSTEM
  C09 AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM
   C09D ANGIOTENSIN II RECEPTOR BLOCKERS (ARBs), COMBINATIONS
    C09DA Angiotensin II receptor blockers (ARBs) and diuretics
     C09DA01 Losartan and diuretics
      D07895  Losartan potassium and hydrochlorothiazide (JP18) <JP/US>
USP drug classification [BR:br08302]
 Cardiovascular Agents
  Cardiovascular Combinations
   Losartan Potassium/ Hydrochlorothiazide
    D07895  Losartan potassium and hydrochlorothiazide (JP18)
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  21  Cardiovascular agents
   214  Antihypertensives
    2149  Others
     D07895  Losartan potassium and hydrochlorothiazide (JP18)
Drug groups [BR:br08330]
 Cardiovascular agent
  DG01925  Renin-angiotensin system inhibitor
   D07895  Losartan potassium and hydrochlorothiazide
 Metabolizing enzyme substrate
  DG01642  CYP2C9 substrate
   D07895  Losartan potassium and hydrochlorothiazide
Drug classes [BR:br08332]
 Cardiovascular agent
  DG01925  Renin-angiotensin system inhibitor
   D07895  Losartan potassium and hydrochlorothiazide
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D07895  Losartan potassium and hydrochlorothiazide tablets
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D07895
Other DBs
PubChem: 96024591
LinkDB

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