 | | DRUG: Losartan potassium | |
| Entry |
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| Name |
Losartan potassium (JP18/USP);
Cozaar (TN) |
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| Product |
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| Generic |
LOSARTAN POTASSIUM (A-S Medication Solutions), LOSARTAN POTASSIUM (A-S Medication Solutions), LOSARTAN POTASSIUM (A-S Medication Solutions), LOSARTAN POTASSIUM (A-S Medication Solutions), LOSARTAN POTASSIUM (A-S Medication Solutions), LOSARTAN POTASSIUM (A-S Medication Solutions), LOSARTAN POTASSIUM (A-S Medication Solutions), LOSARTAN POTASSIUM (A-S Medication Solutions), LOSARTAN POTASSIUM (A-S Medication Solutions), LOSARTAN POTASSIUM (A-S Medication Solutions), LOSARTAN POTASSIUM (A-S Medication Solutions), LOSARTAN POTASSIUM (Alembic Pharmaceuticals Limited), LOSARTAN POTASSIUM (Alembic Pharmaceuticals), LOSARTAN POTASSIUM (American Health Packaging), LOSARTAN POTASSIUM (Aphena Pharma Solutions - Tennessee), LOSARTAN POTASSIUM (Aphena Pharma Solutions - Tennessee), LOSARTAN POTASSIUM (Aphena Pharma Solutions - Tennessee), LOSARTAN POTASSIUM (Aphena Pharma Solutions - Tennessee), LOSARTAN POTASSIUM (Aphena Pharma Solutions - Tennessee), LOSARTAN POTASSIUM (Aphena Pharma Solutions - Tennessee), LOSARTAN POTASSIUM (Aphena Pharma Solutions - Tennessee), LOSARTAN POTASSIUM (Aphena Pharma Solutions - Tennessee), LOSARTAN POTASSIUM (Aphena Pharma Solutions - Tennessee), LOSARTAN POTASSIUM (Aphena Pharma Solutions - Tennessee), LOSARTAN POTASSIUM (Aphena Pharma Solutions - Tennessee), LOSARTAN POTASSIUM (Aphena Pharma Solutions - Tennessee), LOSARTAN POTASSIUM (Aphena Pharma Solutions - Tennessee), LOSARTAN POTASSIUM (Aphena Pharma Solutions - Tennessee), LOSARTAN POTASSIUM (Aphena Pharma Solutions - Tennessee), LOSARTAN POTASSIUM (Aphena Pharma Solutions - Tennessee), LOSARTAN POTASSIUM (Aurobindo Pharma Limited), LOSARTAN POTASSIUM (Aurolife Pharma), LOSARTAN POTASSIUM (Bryant Ranch Prepack), LOSARTAN POTASSIUM (Bryant Ranch Prepack), LOSARTAN POTASSIUM (Bryant Ranch Prepack), LOSARTAN POTASSIUM (Bryant Ranch Prepack), LOSARTAN POTASSIUM (Bryant Ranch Prepack), LOSARTAN POTASSIUM (Bryant Ranch Prepack), LOSARTAN POTASSIUM (Bryant Ranch Prepack), LOSARTAN POTASSIUM (Bryant Ranch Prepack), LOSARTAN POTASSIUM (Bryant Ranch Prepack), LOSARTAN POTASSIUM (Bryant Ranch Prepack), LOSARTAN POTASSIUM (Bryant Ranch Prepack), LOSARTAN POTASSIUM (Bryant Ranch Prepack), LOSARTAN POTASSIUM (Camber Pharmaceuticals), LOSARTAN POTASSIUM (Cardinal Health 107), LOSARTAN POTASSIUM (Cardinal Health 107), LOSARTAN POTASSIUM (DIRECT RX), LOSARTAN POTASSIUM (DIRECT RX), LOSARTAN POTASSIUM (Denton Pharma), LOSARTAN POTASSIUM (Denton Pharma), LOSARTAN POTASSIUM (Denton Pharma), LOSARTAN POTASSIUM (Denton Pharma), LOSARTAN POTASSIUM (Denton Pharma), LOSARTAN POTASSIUM (Direct Rx), LOSARTAN POTASSIUM (DirectRx), LOSARTAN POTASSIUM (DirectRx), LOSARTAN POTASSIUM (Direct_Rx), LOSARTAN POTASSIUM (Granules Pharmaceuticals), LOSARTAN POTASSIUM (Hikma Pharmaceuticals USA), LOSARTAN POTASSIUM (Legacy Pharmaceutical Packaging), LOSARTAN POTASSIUM (Lupin Pharmaceuticals), LOSARTAN POTASSIUM (Macleods Pharmaceuticals Limited), LOSARTAN POTASSIUM (Major Pharmaceuticals), LOSARTAN POTASSIUM (McKesson Corporation dba SKY Packaging), LOSARTAN POTASSIUM (Mckesson Corporation DBA SKY Packaginng), LOSARTAN POTASSIUM (Micro Labs Limited), LOSARTAN POTASSIUM (NCS HealthCare of KY), LOSARTAN POTASSIUM (Northwind Pharmaceuticals), LOSARTAN POTASSIUM (Northwind Pharmaceuticals), LOSARTAN POTASSIUM (Northwind Pharmaceuticals), LOSARTAN POTASSIUM (Northwind Pharmaceuticals), LOSARTAN POTASSIUM (NuCare Pharmaceuticals), LOSARTAN POTASSIUM (NuCare Pharmaceuticals), LOSARTAN POTASSIUM (NuCare Pharmaceuticals), LOSARTAN POTASSIUM (NuCare Pharmaceuticals), LOSARTAN POTASSIUM (NuCare Pharmaceuticals), LOSARTAN POTASSIUM (NuCare Pharmaceuticals), LOSARTAN POTASSIUM (NuCare Pharmaceuticals), LOSARTAN POTASSIUM (NuCare Pharmaceuticals), LOSARTAN POTASSIUM (NuCare Pharmaceuticals), LOSARTAN POTASSIUM (NuCare Pharmaceuticals), LOSARTAN POTASSIUM (NuCare Pharmaceuticals), LOSARTAN POTASSIUM (NuCare Pharmaceuticals), LOSARTAN POTASSIUM (NuCare Pharmaceuticals), LOSARTAN POTASSIUM (NuCarePharmaceuticals), LOSARTAN POTASSIUM (PD-Rx Pharmaceuticals), LOSARTAN POTASSIUM (PD-Rx Pharmaceuticals), LOSARTAN POTASSIUM (PD-Rx Pharmaceuticals), LOSARTAN POTASSIUM (PD-Rx Pharmaceuticals), LOSARTAN POTASSIUM (PD-Rx Pharmaceuticals), LOSARTAN POTASSIUM (PD-Rx Pharmaceuticals), LOSARTAN POTASSIUM (PD-Rx Pharmaceuticals), LOSARTAN POTASSIUM (PD-Rx Pharmaceuticals), LOSARTAN POTASSIUM (PD-Rx Pharmaceuticals), LOSARTAN POTASSIUM (Preferred Pharmaceuticals), LOSARTAN POTASSIUM (Preferred Pharmaceuticals), LOSARTAN POTASSIUM (Preferred Pharmaceuticals), LOSARTAN POTASSIUM (Preferred Pharmaceuticals), LOSARTAN POTASSIUM (Preferred Pharmaceuticals), LOSARTAN POTASSIUM (Preferred Pharmaceuticals), LOSARTAN POTASSIUM (Proficient Rx LP), LOSARTAN POTASSIUM (Proficient Rx LP), LOSARTAN POTASSIUM (Proficient Rx LP), LOSARTAN POTASSIUM (Proficient Rx LP), LOSARTAN POTASSIUM (Proficient Rx LP), LOSARTAN POTASSIUM (Proficient Rx LP), LOSARTAN POTASSIUM (Proficient Rx LP), LOSARTAN POTASSIUM (Proficient Rx LP), LOSARTAN POTASSIUM (Proficient Rx LP), LOSARTAN POTASSIUM (Proficient Rx LP), LOSARTAN POTASSIUM (Proficient Rx LP), LOSARTAN POTASSIUM (Proficient Rx LP), LOSARTAN POTASSIUM (Proficient Rx LP), LOSARTAN POTASSIUM (Proficient Rx LP), LOSARTAN POTASSIUM (QPharma), LOSARTAN POTASSIUM (QPharma), LOSARTAN POTASSIUM (QPharma), LOSARTAN POTASSIUM (QPharma), LOSARTAN POTASSIUM (QPharma), LOSARTAN POTASSIUM (Quallent Pharmaceuticals Health LLC), LOSARTAN POTASSIUM (REMEDYREPACK), LOSARTAN POTASSIUM (REMEDYREPACK), LOSARTAN POTASSIUM (REMEDYREPACK), LOSARTAN POTASSIUM (REMEDYREPACK), LOSARTAN POTASSIUM (REMEDYREPACK), LOSARTAN POTASSIUM (REMEDYREPACK), LOSARTAN POTASSIUM (REMEDYREPACK), LOSARTAN POTASSIUM (REMEDYREPACK), LOSARTAN POTASSIUM (REMEDYREPACK), LOSARTAN POTASSIUM (REMEDYREPACK), LOSARTAN POTASSIUM (Rising Health), LOSARTAN POTASSIUM (ST. MARY'S MEDICAL PARK PHARMACY), LOSARTAN POTASSIUM (Solco Healthcare US), LOSARTAN POTASSIUM (St. Mary's Medical Park Pharmacy), LOSARTAN POTASSIUM (Strides Pharma Science Limited), LOSARTAN POTASSIUM (Torrent Pharmaceuticals Limited), LOSARTAN POTASSIUM (Unichem Pharmaceuticals (USA)), LOSARTAN POTASSIUM (XLCare Pharmaceuticals), LOSARTAN POTASSIUM (Zydus Lifesciences Limited), LOSARTAN POTASSIUM (medsource pharmaceuticals), LOSARTAN POTASSIUM TABLETS, 100 MG (Bryant Ranch Prepack), LOSARTAN POTASSIUM TABLETS, 25 MG (Bryant Ranch Prepack), LOSARTAN POTASSIUM TABLETS, 50 MG (Bryant Ranch Prepack), LOSARTAN POTASSIUM TABLETS, 50 MG (Bryant Ranch Prepack), LOSARTAN POTASSIUM TABLETS, 50 MG (Bryant Ranch Prepack), LOSORTAN POTASSIUM (AvPAK), LOSORTAN POTASSIUM (Bryant Ranch Prepack), LOSORTAN POTASSIUM (Bryant Ranch Prepack), LOSORTAN POTASSIUM (Legacy Pharmaceutical Packaging), LOSORTAN POTASSIUM (Proficient Rx LP), LOSORTAN POTASSIUM (Zydus Pharmaceuticals (USA)) |
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| Formula |
C22H22ClN6O. K
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| Exact mass |
460.1181
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| Mol weight |
461.001
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| Structure |
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| Simcomp |
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| Class |
Cardiovascular agent
DG01925 Renin-angiotensin system inhibitor
DG01495 Angiotensin II receptor antagonist
DG03231 Antihypertensive
DG01495 Angiotensin II receptor antagonist
Metabolizing enzyme substrate
DG01642 CYP2C9 substrate
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| Remark |
| Therapeutic category: | 2149 |
| Product (DG00348): | D00357<JP/US> |
| Product (mixture): | D07895<JP/US> |
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| Efficacy |
Antihypertensive, Angiotensin II receptor antagonist |
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| Disease |
Hypertension [DS: H01633] Nephropathy in type 2 diabetic [DS: H01456] |
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| Target |
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| Pathway |
| hsa04080 | Neuroactive ligand-receptor interaction |
| hsa04261 | Adrenergic signaling in cardiomyocytes |
| hsa04270 | Vascular smooth muscle contraction |
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| Metabolism |
Enzyme: CYP2C9 [HSA: 1559]
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| Interaction |
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| Structure map |
| map07229 | Angiotensin receptor and endothelin receptor antagonists |
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| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
C CARDIOVASCULAR SYSTEM
C09 AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM
C09C ANGIOTENSIN II RECEPTOR BLOCKERS (ARBs), PLAIN
C09CA Angiotensin II receptor blockers (ARBs), plain
C09CA01 Losartan
D00357 Losartan potassium (JP18/USP) <JP/US>
USP drug classification [BR:br08302]
Cardiovascular Agents
Angiotensin II Receptor Antagonists
Losartan
D00357 Losartan potassium (JP18/USP)
Therapeutic category of drugs in Japan [BR:br08301]
2 Agents affecting individual organs
21 Cardiovascular agents
214 Antihypertensives
2149 Others
D00357 Losartan potassium (JP18/USP)
Drug groups [BR:br08330]
Cardiovascular agent
DG01925 Renin-angiotensin system inhibitor
DG01495 Angiotensin II receptor antagonist
DG00348 Losartan
D00357 Losartan potassium
DG03231 Antihypertensive
DG01495 Angiotensin II receptor antagonist
DG00348 Losartan
D00357 Losartan potassium
Metabolizing enzyme substrate
DG01642 CYP2C9 substrate
DG00348 Losartan
D00357 Losartan potassium
Drug classes [BR:br08332]
Cardiovascular agent
DG01495 Angiotensin II receptor antagonist
D00357 Losartan potassium
DG03231 Antihypertensive
D00357 Losartan potassium
Target-based classification of drugs [BR:br08310]
G Protein-coupled receptors
Rhodopsin family
Angiotensin
AGTR1
D00357 Losartan potassium (JP18/USP) <JP/US>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
Chemicals
D00357 Losartan potassium
D00357 Losartan potassium tablets
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
D00357
Drug groups [BR:br08330]
Cardiovascular agent
DG01925 Renin-angiotensin system inhibitor
DG01495 Angiotensin II receptor antagonist
DG00348 Losartan
DG03231 Antihypertensive
DG01495 Angiotensin II receptor antagonist
DG00348 Losartan
Metabolizing enzyme substrate
DG01642 CYP2C9 substrate
DG00348 Losartan
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| Other DBs |
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| LinkDB |
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| KCF data |
ATOM 31
1 N4y N 22.4920 -11.1792
2 C8y C 22.9128 -12.4884
3 C8y C 23.6142 -10.3376
4 C1b C 21.2763 -10.4778
5 N5x N 24.3155 -12.4884
6 C1b C 22.0712 -13.6573
7 C8y C 24.7363 -11.1792
8 C1b C 23.6142 -8.9349
9 C8y C 20.0607 -11.2260
10 C1b C 22.6790 -14.9197
11 X Cl 26.0922 -10.7584
12 O1a O 24.8298 -8.2335
13 C8x C 20.0607 -12.6286
14 C8x C 18.8451 -10.5246
15 C1b C 21.8374 -16.0418
16 C8x C 18.8917 -13.3300
17 C8x C 17.6761 -11.3194
18 C1a C 22.3984 -17.3509
19 C8y C 17.6761 -12.6754
20 C8y C 16.4605 -13.3768
21 C8y C 15.2448 -12.6754
22 C8x C 16.4605 -14.7794
23 C8y C 15.2448 -11.2727
24 C8x C 14.0292 -13.4235
25 C8x C 15.2916 -15.4808
26 N4x N 14.1226 -10.4778 #-
27 N5x N 16.3669 -10.4311
28 C8x C 14.0292 -14.8729
29 N5x N 14.5435 -9.1219
30 N5x N 15.8994 -9.1219
31 Z K 11.0368 -10.5714 #+
BOND 33
1 1 2 1
2 1 3 1
3 1 4 1
4 2 5 2
5 2 6 1
6 3 7 2
7 3 8 1
8 4 9 1
9 6 10 1
10 7 11 1
11 8 12 1
12 9 13 2
13 9 14 1
14 10 15 1
15 13 16 1
16 14 17 2
17 15 18 1
18 16 19 2
19 19 20 1
20 20 21 1
21 20 22 2
22 21 23 1
23 21 24 2
24 22 25 1
25 23 26 1
26 23 27 2
27 24 28 1
28 26 29 1
29 27 30 1
30 5 7 1
31 17 19 1
32 25 28 2
33 29 30 2
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