| Entry |
|
|---|
| Name |
Fludrocortisone (INN);
Astonin-H (TN) |
|---|
| Formula |
C21H29FO5
|
|---|
| Exact mass |
380.1999
|
|---|
| Mol weight |
380.45
|
|---|
| Structure |
|
|---|
| Simcomp |
|
|---|
| Class |
Anti-inflammatory
DG01955 Corticosteroid
|
|---|
| Remark |
| Product (DG00506): | D00986<JP/US> |
|
|---|
| Efficacy |
Salts metabolic regulator |
|---|
| Comment |
mineralocorticoid
|
|---|
| Target |
|
|---|
| Pathway |
| hsa04960 | Aldosterone-regulated sodium reabsorption |
|
|---|
| Interaction |
|
|---|
| Structure map |
| map07225 | Glucocorticoid and mineralocorticoid receptor agonists/antagonists |
|
|---|
| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
H SYSTEMIC HORMONAL PREPARATIONS, EXCL. SEX HORMONES AND INSULINS
H02 CORTICOSTEROIDS FOR SYSTEMIC USE
H02A CORTICOSTEROIDS FOR SYSTEMIC USE, PLAIN
H02AA Mineralocorticoids
H02AA02 Fludrocortisone
D07967 Fludrocortisone (INN)
Drug groups [BR:br08330]
Anti-inflammatory
DG01955 Corticosteroid
DG00506 Fludrocortisone
D07967 Fludrocortisone
Target-based classification of drugs [BR:br08310]
Nuclear receptors
Estrogen like receptors
3-Ketosteroid receptor
NR3C2 (MR)
D07967 Fludrocortisone (INN)
Drug groups [BR:br08330]
Anti-inflammatory
DG01955 Corticosteroid
DG00506 Fludrocortisone
|
|---|
| Other DBs |
|
|---|
| LinkDB |
|
|---|
| KCF data |
ATOM 27
1 C1x C 22.7500 -19.8800
2 C5x C 22.7500 -21.2100
3 C2x C 23.9400 -21.9100
4 C2y C 25.1300 -21.2100
5 C1z C 25.1300 -19.8800
6 C1x C 23.9400 -19.1800
7 C1x C 26.3200 -21.9100
8 C1x C 27.5100 -21.2100
9 C1y C 27.5100 -19.8800
10 C1z C 26.3200 -19.1800
11 C1y C 28.6300 -19.1800
12 C1z C 28.6300 -17.7800
13 C1x C 27.5100 -17.1500
14 C1y C 26.3200 -17.7800
15 O5x O 21.6300 -21.9100
16 C1a C 25.1300 -18.4800
17 O1a O 25.1300 -17.1500
18 C1a C 28.6300 -16.4500
19 X F 26.3200 -20.5800
20 C1x C 31.0100 -19.1800
21 C1x C 31.0100 -17.7800
22 C1z C 29.8200 -17.1500
23 C5a C 29.8200 -15.5400
24 C1b C 28.6300 -14.8400
25 O5a O 31.0100 -14.8400
26 O1a O 27.4400 -15.5400
27 O1a O 31.0100 -16.4500
BOND 30
1 1 2 1
2 2 3 1
3 3 4 2
4 4 5 1
5 5 6 1
6 1 6 1
7 4 7 1
8 7 8 1
9 8 9 1
10 9 10 1
11 5 10 1
12 9 11 1
13 11 12 1
14 12 13 1
15 13 14 1
16 10 14 1
17 2 15 2
18 5 16 1 #Up
19 14 17 1 #Up
20 12 18 1 #Up
21 10 19 1 #Down
22 11 20 1
23 20 21 1
24 21 22 1
25 12 22 1
26 22 23 1 #Up
27 23 24 1
28 23 25 2
29 24 26 1
30 22 27 1 #Down
|
|---|
