Entry |
|
Name |
Sodium furosemide; Frosemide sodium; Lasix (TN) |
Formula |
C12H10ClN2O5S. Na
|
Exact mass |
351.9897
|
Mol weight |
352.73
|
Structure |

|
Simcomp |
|
Class |
|
Remark |
Product (DG00272): | D00331<JP/US> |
|
Efficacy |
Diuretic, Na-K-Cl cotransporter inhibitor |
Comment |
loop diuretic
Sulufonamide derivative
|
Target |
|
Metabolism |
Transporter: SLC22A6 [HSA: 9356], SLC22A8 [HSA: 9376], ABCC4 [HSA: 10257]
|
Interaction |
|
Structure map |
map07017 | Sulfonamide derivatives - diuretics |
map07055 | Sulfonamide derivatives - overview |
|
Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
C CARDIOVASCULAR SYSTEM
C03 DIURETICS
C03C HIGH-CEILING DIURETICS
C03CA Sulfonamides, plain
C03CA01 Furosemide
D07999 Sodium furosemide
Drug groups [BR:br08330]
Cardiovascular agent
DG01690 Sulfonamide diuretic
DG01747 Furosemide type diuretic
DG00272 Furosemide
D07999 Sodium furosemide
DG01748 Loop diuretic
DG01747 Furosemide type diuretic
DG00272 Furosemide
D07999 Sodium furosemide
Transporter substrate
DG02920 ABCC4 substrate
DG00272 Furosemide
D07999 Sodium furosemide
DG02859 SLC22A6 substrate
DG00272 Furosemide
D07999 Sodium furosemide
DG02860 SLC22A8 substrate
DG00272 Furosemide
D07999 Sodium furosemide
Target-based classification of drugs [BR:br08310]
Transporters
Solute carrier family
SLC12
SLC12A1 (NKCC2)
D07999 Sodium furosemide
SLC12A2 (NKCC1)
D07999 Sodium furosemide
Drug metabolizing enzymes and transporters [br08309.html]
Drug transporters
D07999
Drug groups [BR:br08330]
Cardiovascular agent
DG01690 Sulfonamide diuretic
DG01747 Furosemide type diuretic
DG00272 Furosemide
DG01748 Loop diuretic
DG01747 Furosemide type diuretic
DG00272 Furosemide
Transporter substrate
DG02920 ABCC4 substrate
DG00272 Furosemide
DG02859 SLC22A6 substrate
DG00272 Furosemide
DG02860 SLC22A8 substrate
DG00272 Furosemide
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Other DBs |
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LinkDB |
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KCF data |
ATOM 22
1 C8y C 25.8300 -16.8700
2 C8y C 24.5700 -17.5700
3 C8x C 27.0200 -17.5700
4 C6a C 25.8300 -15.4700
5 C8x C 24.5700 -18.9700
6 N1b N 23.3800 -16.8700
7 C8y C 27.0200 -18.9700
8 O6a O 24.6400 -14.7700
9 O6a O 27.0200 -14.7700 #-
10 C8y C 25.8300 -19.6700
11 C1b C 22.1900 -17.5700
12 S4a S 28.2100 -19.6700
13 X Cl 25.8300 -21.0700
14 C8y C 21.0000 -16.8000
15 N1a N 29.4700 -20.3700
16 O3c O 27.5100 -20.8600
17 O3c O 28.9800 -18.4800
18 O2x O 21.0000 -15.4000
19 C8x C 19.6700 -14.9800
20 C8x C 18.8300 -16.1000
21 C8x C 19.6700 -17.2900
22 Z Na 30.0300 -14.5600 #+
BOND 22
1 1 2 2
2 1 3 1
3 1 4 1
4 2 5 1
5 2 6 1
6 3 7 2
7 4 8 2
8 4 9 1
9 5 10 2
10 6 11 1
11 7 12 1
12 10 13 1
13 11 14 1
14 12 15 1
15 12 16 2
16 12 17 2
17 7 10 1
18 14 18 1
19 18 19 1
20 19 20 2
21 20 21 1
22 14 21 2
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