| Entry |
|
|---|
| Name |
Furosemide diolamine;
Furosemide diethanolamine salt;
Nuriban (TN) |
|---|
| Formula |
C12H11ClN2O5S. C4H11NO2
|
|---|
| Exact mass |
435.0867
|
|---|
| Mol weight |
435.8798
|
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| Structure |
|
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| Class |
|
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| Remark |
| Product (DG00272): | D00331<JP/US> |
|
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| Efficacy |
Diuretic, Na-K-Cl cotransporter inhibitor |
|---|
| Comment |
loop diuretic
Sulufonamide derivative
|
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| Target |
|
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| Metabolism |
Transporter: SLC22A6 [HSA: 9356], SLC22A8 [HSA: 9376], ABCC4 [HSA: 10257]
|
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| Interaction |
|
|---|
| Structure map |
| map07017 | Sulfonamide derivatives - diuretics |
| map07055 | Sulfonamide derivatives - overview |
|
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| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
C CARDIOVASCULAR SYSTEM
C03 DIURETICS
C03C HIGH-CEILING DIURETICS
C03CA Sulfonamides, plain
C03CA01 Furosemide
D08001 Furosemide diolamine
Drug groups [BR:br08330]
Cardiovascular agent
DG01690 Sulfonamide diuretic
DG01747 Furosemide type diuretic
DG00272 Furosemide
D08001 Furosemide diolamine
DG01748 Loop diuretic
DG01747 Furosemide type diuretic
DG00272 Furosemide
D08001 Furosemide diolamine
Transporter substrate
DG02920 ABCC4 substrate
DG00272 Furosemide
D08001 Furosemide diolamine
DG02859 SLC22A6 substrate
DG00272 Furosemide
D08001 Furosemide diolamine
DG02860 SLC22A8 substrate
DG00272 Furosemide
D08001 Furosemide diolamine
Target-based classification of drugs [BR:br08310]
Transporters
Solute carrier family
SLC12
SLC12A1 (NKCC2)
D08001 Furosemide diolamine
SLC12A2 (NKCC1)
D08001 Furosemide diolamine
Drug metabolizing enzymes and transporters [br08309.html]
Drug transporters
D08001
Drug groups [BR:br08330]
Cardiovascular agent
DG01690 Sulfonamide diuretic
DG01747 Furosemide type diuretic
DG00272 Furosemide
DG01748 Loop diuretic
DG01747 Furosemide type diuretic
DG00272 Furosemide
Transporter substrate
DG02920 ABCC4 substrate
DG00272 Furosemide
DG02859 SLC22A6 substrate
DG00272 Furosemide
DG02860 SLC22A8 substrate
DG00272 Furosemide
|
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| Other DBs |
|
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| LinkDB |
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| KCF data |
ATOM 28
1 C8y C 20.2300 -16.8700
2 C8y C 18.9700 -17.5700
3 C8x C 21.4200 -17.5700
4 C6a C 20.2300 -15.4700
5 C8x C 18.9700 -18.9700
6 N1b N 17.7800 -16.8700
7 C8y C 21.4200 -18.9700
8 O6a O 19.0400 -14.7700
9 O6a O 21.4200 -14.7700
10 C8y C 20.2300 -19.6700
11 C1b C 16.5900 -17.5700
12 S4a S 22.6100 -19.6700
13 X Cl 20.2300 -21.0700
14 C8y C 15.4000 -16.8000
15 N1a N 23.8700 -20.3700
16 O3c O 21.9100 -20.8600
17 O3c O 23.3800 -18.4800
18 O2x O 15.4000 -15.4000
19 C8x C 14.0700 -14.9800
20 C8x C 13.2300 -16.1000
21 C8x C 14.0700 -17.2900
22 O1a O 28.1400 -18.6200
23 C1b C 29.3524 -17.9200
24 C1b C 30.5649 -18.6200
25 N1b N 31.7773 -17.9200
26 C1b C 32.9897 -18.6200
27 C1b C 34.2022 -17.9200
28 O1a O 35.4146 -18.6200
BOND 28
1 1 2 2
2 1 3 1
3 1 4 1
4 2 5 1
5 2 6 1
6 3 7 2
7 4 8 2
8 4 9 1
9 5 10 2
10 6 11 1
11 7 12 1
12 10 13 1
13 11 14 1
14 12 15 1
15 12 16 2
16 12 17 2
17 7 10 1
18 14 18 1
19 18 19 1
20 19 20 2
21 20 21 1
22 14 21 2
23 22 23 1
24 23 24 1
25 24 25 1
26 25 26 1
27 26 27 1
28 27 28 1
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