KEGG   DRUG: GuanethidineHelp
Entry
D08030                      Drug                                   

Name
Guanethidine (INN)
Formula
C10H22N4
Exact mass
198.1844
Mol weight
198.3085
Structure
Mol fileKCF fileDB search
Simcomp SIMCOMP
Class
Cardiovascular agent
 DG01739  Peripherally-acting antiadrenergic
Remark
Same as: C07036
ATC code: C02CC02 S01EX01
Chemical structure group: DG00258
Efficacy
Antihypertensive, Miotic, Noradrenaline release inhibitor
Comment
Guanidine derivative
Target
SLC6A2 (NAT1) [HSA:6530] [KO:K05035]
Interaction
Drug interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 C CARDIOVASCULAR SYSTEM
  C02 ANTIHYPERTENSIVES
   C02C ANTIADRENERGIC AGENTS, PERIPHERALLY ACTING
    C02CC Guanidine derivatives
     C02CC02 Guanethidine
      D08030  Guanethidine (INN)
 S SENSORY ORGANS
  S01 OPHTHALMOLOGICALS
   S01E ANTIGLAUCOMA PREPARATIONS AND MIOTICS
    S01EX Other antiglaucoma preparations
     S01EX01 Guanethidine
      D08030  Guanethidine (INN)
Target-based classification of drugs [BR:br08310]
 Transporters
  Solute carrier family
   SLC6
    SLC6A2 (NAT1)
     D08030  Guanethidine (INN)
BRITE hierarchy
Other DBs
CAS: 55-65-2
PubChem: 96024723
ChEBI: 5557
ChEMBL: CHEMBL765
DrugBank: DB01170
LigandBox: D08030
NIKKAJI: J4.562D
LinkDB All DBs
KCF data Show

ATOM        14
            1   N1y N    25.4100  -17.2200
            2   C1b C    24.2200  -16.5200
            3   C1x C    25.3400  -18.6900
            4   C1x C    26.3900  -16.2400
            5   C1b C    23.0300  -17.2200
            6   C1x C    26.3900  -19.6700
            7   C1x C    27.8600  -16.2400
            8   N1b N    21.8400  -16.5200
            9   C1x C    27.7900  -19.6700
            10  C1x C    28.8400  -17.2200
            11  C2c C    20.7200  -17.2200
            12  C1x C    28.8400  -18.6900
            13  N1a N    19.5300  -16.5200
            14  N2a N    20.7200  -18.5500
BOND        14
            1     1   2 1
            2     1   3 1
            3     1   4 1
            4     2   5 1
            5     3   6 1
            6     4   7 1
            7     5   8 1
            8     6   9 1
            9     7  10 1
            10    8  11 1
            11    9  12 1
            12   11  13 1
            13   11  14 2
            14   10  12 1

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