KEGG   DRUG: Hydromorphone
Entry
D08047                      Drug                                   
Name
Hydromorphone (INN)
Formula
C17H19NO3
Exact mass
285.1365
Mol weight
285.3377
Structure
Simcomp
Class
Neuropsychiatric agent
 DG01564  Opioid receptor agonist
  DG01563  mu-Opioid receptor agonist
Analgesic
 DG01984  Opioid analgesics
Metabolizing enzyme substrate
 DG02924  UGT substrate
Remark
Same as: C07042
ATC code: N02AA03
Chemical structure group: DG00811
Product (DG00811): D00839<JP/US>
Efficacy
Analgesic (narcotic), Opioid receptor agonist
Comment
Opium alkaloid
Target
OPRM1 [HSA:4988] [KO:K04215]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
Metabolism
Enzyme: UGT [KO:K00699]
Interaction
Structure map
map07039  Opioid analgesics
map07224  Opioid receptor agonists/antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N02 ANALGESICS
   N02A OPIOIDS
    N02AA Natural opium alkaloids
     N02AA03 Hydromorphone
      D08047  Hydromorphone (INN)
Drug groups [BR:br08330]
 Neuropsychiatric agent
  DG01564  Opioid receptor agonist
   DG01563  mu-Opioid receptor agonist
    DG00811  Hydromorphone
     D08047  Hydromorphone
 Analgesic
  DG01984  Opioid analgesics
   DG00811  Hydromorphone
    D08047  Hydromorphone
 Metabolizing enzyme substrate
  DG02924  UGT substrate
   DG00811  Hydromorphone
    D08047  Hydromorphone
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Opioid
    OPRM1
     D08047  Hydromorphone (INN)
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D08047
Drug groups [BR:br08330]
 Neuropsychiatric agent
  DG01564  Opioid receptor agonist
   DG01563  mu-Opioid receptor agonist
    DG00811  Hydromorphone
 Analgesic
  DG01984  Opioid analgesics
   DG00811  Hydromorphone
 Metabolizing enzyme substrate
  DG02924  UGT substrate
   DG00811  Hydromorphone
Other DBs
CAS: 466-99-9
PubChem: 96024740
ChEBI: 5790
LigandBox: D08047
NIKKAJI: J5.904H
LinkDB
KCF data

ATOM        21
            1   C1z C    23.0300  -18.6200
            2   C8y C    23.0300  -17.2900
            3   C1y C    24.2200  -19.2500
            4   C1y C    21.9100  -19.1800
            5   C1x C    24.2200  -17.9900
            6   C8y C    21.9100  -16.6600
            7   C8y C    24.2200  -16.6600
            8   C1y C    25.3400  -18.6200
            9   C1x C    24.2200  -20.5100
            10  O2x O    20.5800  -17.9200
            11  C5x C    21.9100  -20.5100
            12  C1x C    26.3900  -17.9900
            13  C8y C    21.9100  -15.3300
            14  C1x C    25.3400  -17.3600
            15  C8x C    24.2200  -15.3300
            16  N1y N    26.3900  -19.2500
            17  C1x C    23.0300  -21.2100
            18  O5x O    20.7900  -21.2100
            19  C8x C    23.1000  -14.7000
            20  O1a O    20.7900  -14.7000
            21  C1a C    27.7900  -19.2500
BOND        25
            1     1   2 1
            2     1   3 1
            3     1   4 1
            4     1   5 1 #Up
            5     2   6 2
            6     2   7 1
            7     3   8 1
            8     3   9 1
            9     4  10 1 #Down
            10    4  11 1
            11    5  12 1
            12    6  13 1
            13    7  14 1
            14    7  15 2
            15    8  16 1 #Up
            16    9  17 1
            17   11  18 2
            18   13  19 2
            19   13  20 1
            20    6  10 1
            21    8  14 1
            22   11  17 1
            23   12  16 1
            24   15  19 1
            25   16  21 1

» Japanese version   » Back

KEGG   DRUG: Hydromorphone hydrochloride
Entry
D00839                      Drug                                   
Name
Hydromorphone hydrochloride (JAN/USP);
Dilaudid (TN);
Exalgo (TN);
Palladone (TN)
Product
  Generic
Formula
C17H19NO3. HCl
Exact mass
321.1132
Mol weight
321.7986
Structure
Simcomp
Class
Neuropsychiatric agent
 DG01564  Opioid receptor agonist
  DG01563  mu-Opioid receptor agonist
Analgesic
 DG01984  Opioid analgesics
Metabolizing enzyme substrate
 DG02924  UGT substrate
Remark
Therapeutic category: 8119
ATC code: N02AA03
Chemical structure group: DG00811
Product (DG00811): D00839<JP/US>
Efficacy
Analgesic (narcotic), Opioid receptor agonist
Comment
Opium alkaloid
Target
OPRM1 [HSA:4988] [KO:K04215]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
Metabolism
Enzyme: UGT [KO:K00699]
Interaction
Structure map
map07039  Opioid analgesics
map07224  Opioid receptor agonists/antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N02 ANALGESICS
   N02A OPIOIDS
    N02AA Natural opium alkaloids
     N02AA03 Hydromorphone
      D00839  Hydromorphone hydrochloride (JAN/USP) <JP/US>
USP drug classification [BR:br08302]
 Analgesics
  Opioid Analgesics, Long-acting
   Hydromorphone
    D00839  Hydromorphone hydrochloride (JAN/USP)
  Opioid Analgesics, Short-acting
   Hydromorphone
    D00839  Hydromorphone hydrochloride (JAN/USP)
Therapeutic category of drugs in Japan [BR:br08301]
 8  Narcotics
  81  Alkaloidal narcotics
   811  Opium alkaloids
    8119  Others
     D00839  Hydromorphone hydrochloride (JAN/USP)
Drug groups [BR:br08330]
 Neuropsychiatric agent
  DG01564  Opioid receptor agonist
   DG01563  mu-Opioid receptor agonist
    DG00811  Hydromorphone
     D00839  Hydromorphone hydrochloride
 Analgesic
  DG01984  Opioid analgesics
   DG00811  Hydromorphone
    D00839  Hydromorphone hydrochloride
 Metabolizing enzyme substrate
  DG02924  UGT substrate
   DG00811  Hydromorphone
    D00839  Hydromorphone hydrochloride
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Opioid
    OPRM1
     D00839  Hydromorphone hydrochloride (JAN/USP) <JP/US>
New drug approvals in Japan [br08318.html]
 Drugs with new active ingredients
  D00839
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D00839
Drug groups [BR:br08330]
 Neuropsychiatric agent
  DG01564  Opioid receptor agonist
   DG01563  mu-Opioid receptor agonist
    DG00811  Hydromorphone
 Analgesic
  DG01984  Opioid analgesics
   DG00811  Hydromorphone
 Metabolizing enzyme substrate
  DG02924  UGT substrate
   DG00811  Hydromorphone
Other DBs
CAS: 71-68-1
PubChem: 7847904
ChEBI: 5791
LigandBox: D00839
NIKKAJI: J252.891F
LinkDB
KCF data

ATOM        22
            1   X   Cl   33.7684  -12.5160
            2   C1z C    26.4194  -13.3594
            3   C8y C    26.4194  -12.0354
            4   C1y C    27.6040  -14.0561
            5   C1y C    25.3045  -13.9865
            6   C1x C    27.6040  -12.7323
            7   C8y C    25.3045  -11.4083
            8   C8y C    27.6040  -11.4083
            9   C1y C    28.7189  -13.3594
            10  C1x C    27.6040  -15.3104
            11  O2x O    23.9806  -12.6625
            12  C5x C    25.3045  -15.3104
            13  C1x C    29.8337  -12.7323
            14  C8y C    25.3045  -10.0844
            15  C1x C    28.7189  -12.1051
            16  C8x C    27.6040  -10.0844
            17  N1y N    29.8337  -14.0561
            18  C1x C    26.4194  -16.0072
            19  O5x O    24.1897  -16.0072
            20  C8x C    26.4891   -9.4573
            21  O1a O    24.1897   -9.4573
            22  C1a C    31.2326  -14.0561
BOND        25
            1     2   3 1
            2     2   4 1
            3     2   5 1
            4     2   6 1 #Up
            5     3   7 2
            6     3   8 1
            7     4   9 1
            8     4  10 1
            9     5  11 1 #Down
            10    5  12 1
            11    6  13 1
            12    7  14 1
            13    8  15 1
            14    8  16 2
            15    9  17 1 #Up
            16   10  18 1
            17   12  19 2
            18   14  20 2
            19   14  21 1
            20    7  11 1
            21    9  15 1
            22   12  18 1
            23   13  17 1
            24   16  20 1
            25   17  22 1

» Japanese version   » Back

DBGET integrated database retrieval system