KEGG   DRUG: Imidapril
Entry
D08068                      Drug                                   
Name
Imidapril (INN);
Hipertene (TN)
Formula
C20H27N3O6
Exact mass
405.19
Mol weight
405.4449
Structure
Simcomp
Class
Cardiovascular agent
 DG01925  Renin-angiotensin system inhibitor
  DG01501  Angiotensin-converting enzyme inhibitor
 DG03231  Antihypertensive
  DG01501  Angiotensin-converting enzyme inhibitor
Remark
ATC code: C09AA16
Chemical structure group: DG00347
Product (DG00347): D01549<JP>
Efficacy
Antihypertensive, Angiotensin-converting enzyme inhibitor
Comment
Active form of prodrug: Imidaprilat [CPD:C21519]
Target
ACE (CD143) [HSA:1636] [KO:K01283]
  Pathway
hsa04614  Renin-angiotensin system
Interaction
Structure map
map07217  Renin-angiotensin system inhibitors
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 C CARDIOVASCULAR SYSTEM
  C09 AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM
   C09A ACE INHIBITORS, PLAIN
    C09AA ACE inhibitors, plain
     C09AA16 Imidapril
      D08068  Imidapril (INN)
Drug groups [BR:br08330]
 Cardiovascular agent
  DG01925  Renin-angiotensin system inhibitor
   DG01501  Angiotensin-converting enzyme inhibitor
    DG00347  Imidapril
     D08068  Imidapril
  DG03231  Antihypertensive
   DG01501  Angiotensin-converting enzyme inhibitor
    DG00347  Imidapril
     D08068  Imidapril
Target-based classification of drugs [BR:br08310]
 Enzymes
  Hydrolases (EC3)
   Peptidyl-dipeptidases
    ACE (CD143)
     D08068  Imidapril (INN)
Prodrugs [br08324.html]
 D08068
Drug groups [BR:br08330]
 Cardiovascular agent
  DG01925  Renin-angiotensin system inhibitor
   DG01501  Angiotensin-converting enzyme inhibitor
    DG00347  Imidapril
  DG03231  Antihypertensive
   DG01501  Angiotensin-converting enzyme inhibitor
    DG00347  Imidapril
Prodrugs [br08324.html]
 DG00347
Other DBs
CAS: 89371-37-9
PubChem: 96024759
ChEBI: 135654
LigandBox: D08068
LinkDB
KCF data

ATOM        29
            1   C8x C    15.6800  -19.1100
            2   C8x C    15.6800  -20.5100
            3   C8x C    16.9400  -21.2100
            4   C8x C    18.1300  -20.5100
            5   C8y C    18.1300  -19.1100
            6   C8x C    16.9400  -18.4100
            7   C1b C    19.3900  -18.4100
            8   C1b C    20.5800  -19.1100
            9   C1c C    21.8400  -18.4100
            10  N1b N    23.0300  -19.1100
            11  C1c C    24.2200  -18.4100
            12  C5a C    25.4800  -19.1100
            13  N1y N    26.6700  -18.4100
            14  C7a C    21.8400  -17.0100
            15  C1a C    24.2200  -17.0100
            16  O6a O    23.0300  -16.3100
            17  O7a O    20.5800  -16.3100
            18  C1b C    19.3900  -17.0100
            19  C1a C    18.2000  -16.3100
            20  O5a O    25.4800  -20.5100
            21  C5x C    27.7900  -19.2500
            22  N1y N    28.9100  -18.4100
            23  C1x C    28.4900  -17.0800
            24  C1y C    27.0900  -17.0800
            25  O5x O    27.7900  -20.6500
            26  C1a C    30.1000  -19.1100
            27  O6a O    27.0900  -14.7000
            28  C6a C    26.3900  -15.8900
            29  O6a O    24.9900  -15.8900
BOND        30
            1     1   2 2
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 2
            6     1   6 1
            7     5   7 1
            8     7   8 1
            9     8   9 1
            10    9  10 1
            11   10  11 1
            12   11  12 1
            13   12  13 1
            14    9  14 1 #Up
            15   11  15 1 #Up
            16   14  16 2
            17   14  17 1
            18   17  18 1
            19   18  19 1
            20   12  20 2
            21   13  21 1
            22   21  22 1
            23   22  23 1
            24   23  24 1
            25   13  24 1
            26   21  25 2
            27   22  26 1
            28   27  28 1
            29   24  28 1 #Down
            30   28  29 2

» Japanese version   » Back

KEGG   DRUG: Imidapril hydrochloride
Entry
D01549                      Drug                                   
Name
Imidapril hydrochloride (JP18);
Tanatril (TN)
Formula
C20H27N3O6. HCl
Exact mass
441.1667
Mol weight
441.9058
Structure
Simcomp
Class
Cardiovascular agent
 DG01925  Renin-angiotensin system inhibitor
  DG01501  Angiotensin-converting enzyme inhibitor
 DG03231  Antihypertensive
  DG01501  Angiotensin-converting enzyme inhibitor
Remark
Therapeutic category: 2144
ATC code: C09AA16
Chemical structure group: DG00347
Product (DG00347): D01549<JP>
Efficacy
Antihypertensive, Angiotensin-converting enzyme inhibitor
Comment
Active form of prodrug: Imidaprilat [CPD:C21519]
Target
ACE (CD143) [HSA:1636] [KO:K01283]
  Pathway
hsa04614  Renin-angiotensin system
Interaction
Structure map
map07217  Renin-angiotensin system inhibitors
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 C CARDIOVASCULAR SYSTEM
  C09 AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM
   C09A ACE INHIBITORS, PLAIN
    C09AA ACE inhibitors, plain
     C09AA16 Imidapril
      D01549  Imidapril hydrochloride (JP18) <JP>
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  21  Cardiovascular agents
   214  Antihypertensives
    2144  Angiotensin converting enzyme inhibitors
     D01549  Imidapril hydrochloride (JP18)
Drug groups [BR:br08330]
 Cardiovascular agent
  DG01925  Renin-angiotensin system inhibitor
   DG01501  Angiotensin-converting enzyme inhibitor
    DG00347  Imidapril
     D01549  Imidapril hydrochloride
  DG03231  Antihypertensive
   DG01501  Angiotensin-converting enzyme inhibitor
    DG00347  Imidapril
     D01549  Imidapril hydrochloride
Drug classes [BR:br08332]
 Cardiovascular agent
  DG01501  Angiotensin-converting enzyme inhibitor
   D01549  Imidapril hydrochloride
  DG03231  Antihypertensive
   D01549  Imidapril hydrochloride
Target-based classification of drugs [BR:br08310]
 Enzymes
  Hydrolases (EC3)
   Peptidyl-dipeptidases
    ACE (CD143)
     D01549  Imidapril hydrochloride (JP18) <JP>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D01549  Imidapril hydrochloride
  D01549  Imidapril hydrochloride tablets
Drug groups [BR:br08330]
 Cardiovascular agent
  DG01925  Renin-angiotensin system inhibitor
   DG01501  Angiotensin-converting enzyme inhibitor
    DG00347  Imidapril
  DG03231  Antihypertensive
   DG01501  Angiotensin-converting enzyme inhibitor
    DG00347  Imidapril
Prodrugs [br08324.html]
 DG00347
Other DBs
CAS: 89396-94-1
PubChem: 7848612
ChEBI: 31691
LigandBox: D01549
NIKKAJI: J427.891G
LinkDB
KCF data

ATOM        30
            1   X   Cl   38.7644  -14.3286
            2   C8x C    21.8083  -15.6375
            3   C8x C    21.8083  -17.0398
            4   C8x C    23.0228  -17.7410
            5   C8x C    24.2373  -17.0398
            6   C8y C    24.2373  -15.6375
            7   C8x C    23.0228  -14.9363
            8   C1b C    25.4768  -14.9363
            9   C1b C    26.6914  -15.6375
            10  C1c C    27.9058  -14.9363
            11  N1b N    29.1202  -15.6375
            12  C1c C    30.3347  -14.9363
            13  C5a C    31.5491  -15.6375
            14  N1y N    32.7635  -14.9363
            15  C7a C    27.9058  -13.5340
            16  C1a C    30.3347  -13.5343
            17  O6a O    29.1223  -12.8316
            18  O7a O    26.6934  -12.8341
            19  C1b C    25.4969  -13.5250
            20  C1a C    24.3071  -12.8381
            21  O5a O    31.5491  -17.0398
            22  C5x C    33.8906  -15.7472
            23  N1y N    35.0069  -14.9244
            24  C1x C    34.5693  -13.6085
            25  C1y C    33.1826  -13.5481
            26  O5x O    33.8994  -17.1798
            27  C1a C    36.2214  -15.6256
            28  O6a O    33.1659  -11.1893
            29  C6a C    32.4732  -12.4085
            30  O6a O    31.0637  -12.4182
BOND        30
            1     2   3 2
            2     3   4 1
            3     4   5 2
            4     5   6 1
            5     6   7 2
            6     2   7 1
            7     6   8 1
            8     8   9 1
            9     9  10 1
            10   10  11 1
            11   11  12 1
            12   12  13 1
            13   13  14 1
            14   10  15 1 #Up
            15   12  16 1 #Up
            16   15  17 2
            17   15  18 1
            18   18  19 1
            19   19  20 1
            20   13  21 2
            21   14  22 1
            22   22  23 1
            23   23  24 1
            24   24  25 1
            25   14  25 1
            26   22  26 2
            27   23  27 1
            28   28  29 1
            29   25  29 1 #Down
            30   29  30 2

» Japanese version   » Back

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