Homo sapiens (human): 1636
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Entry
1636 CDS
T01001
Symbol
ACE, ACE1, CD143, DCP, DCP1
Name
(RefSeq) angiotensin I converting enzyme
KO
K01283
peptidyl-dipeptidase A [EC:
3.4.15.1
]
Organism
hsa
Homo sapiens (human)
Pathway
hsa04614
Renin-angiotensin system
hsa04924
Renin secretion
hsa05142
Chagas disease
hsa05171
Coronavirus disease - COVID-19
hsa05410
Hypertrophic cardiomyopathy
hsa05415
Diabetic cardiomyopathy
Network
nt06316
Renin-angiotensin-aldosterone signaling
Element
N01743
Renin-angiotensin signaling pathway
Disease
H00083
Allograft rejection
H00575
Renal tubular dysgenesis
H01456
Diabetic nephropathy
H01457
Diabetic retinopathy
H02559
Microvascular complications of diabetes
Drug target
Alacepril:
D01900
<JP>
Benazepril (
DG00339
):
D00620
<JP/US>
D07499
Benazeprilat:
D03077
Captopril:
D00251
<JP/US>
Ceronapril:
D03440
Cilazapril (
DG00340
):
D01069
D07699
Delapril (
DG00343
):
D01667
<JP>
D07781
Enalapril (
DG00335
):
D00621
<JP/US>
D07892
Enalaprilat:
D03769
<US>
Fosinopril (
DG00341
):
D00622
<US>
D07992
Fosinoprilat:
D03772
Gemopatrilat:
D04312
Imidapril (
DG00347
):
D01549
<JP>
D08068
Indolapril hydrochloride:
D03756
Libenzapril:
D03758
Lisinopril (
DG00336
):
D00362
<JP/US>
D08131
Moexipril (
DG00344
):
D00623
<US>
D08225
Pentopril:
D03760
Perindopril (
DG00337
):
D00624
<JP/US>
D03753
D11580
Pivopril:
D03763
Quinapril (
DG00338
):
D00459
<US>
D03752
Quinaprilat:
D03773
Ramipril:
D00421
<US>
Spirapril (
DG00342
):
D03765
D08529
Spiraprilat:
D03775
Temocapril (
DG00345
):
D01119
<JP>
D08566
Teprotide:
D06076
Trandolapril:
D00383
<JP/US>
Zofenopril (
DG00346
):
D03767
D08688
Zofenoprilat arginine:
D03776
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09150 Organismal Systems
09152 Endocrine system
04924 Renin secretion
1636 (ACE)
04614 Renin-angiotensin system
1636 (ACE)
09160 Human Diseases
09172 Infectious disease: viral
05171 Coronavirus disease - COVID-19
1636 (ACE)
09174 Infectious disease: parasitic
05142 Chagas disease
1636 (ACE)
09166 Cardiovascular disease
05410 Hypertrophic cardiomyopathy
1636 (ACE)
05415 Diabetic cardiomyopathy
1636 (ACE)
09180 Brite Hierarchies
09181 Protein families: metabolism
01002 Peptidases and inhibitors [BR:
hsa01002
]
1636 (ACE)
09183 Protein families: signaling and cellular processes
04147 Exosome [BR:
hsa04147
]
1636 (ACE)
04090 CD molecules [BR:
hsa04090
]
1636 (ACE)
Enzymes [BR:
hsa01000
]
3. Hydrolases
3.4 Acting on peptide bonds (peptidases)
3.4.15 Peptidyl-dipeptidases
3.4.15.1 peptidyl-dipeptidase A
1636 (ACE)
Peptidases and inhibitors [BR:
hsa01002
]
Metallo peptidases
Family M2
1636 (ACE)
Exosome [BR:
hsa04147
]
Exosomal proteins
Exosomal proteins of other body fluids (saliva and urine)
1636 (ACE)
CD molecules [BR:
hsa04090
]
Proteins
1636 (ACE)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
Peptidase_M2
Motif
Other DBs
NCBI-GeneID:
1636
NCBI-ProteinID:
NP_000780
OMIM:
106180
HGNC:
2707
Ensembl:
ENSG00000159640
UniProt:
P12821
B4DKH4
Structure
PDB
LinkDB
All DBs
Position
17:63477061..63498373
Genome browser
AA seq
1306 aa
AA seq
DB search
MGAASGRRGPGLLLPLPLLLLLPPQPALALDPGLQPGNFSADEAGAQLFAQSYNSSAEQV
LFQSVAASWAHDTNITAENARRQEEAALLSQEFAEAWGQKAKELYEPIWQNFTDPQLRRI
IGAVRTLGSANLPLAKRQQYNALLSNMSRIYSTAKVCLPNKTATCWSLDPDLTNILASSR
SYAMLLFAWEGWHNAAGIPLKPLYEDFTALSNEAYKQDGFTDTGAYWRSWYNSPTFEDDL
EHLYQQLEPLYLNLHAFVRRALHRRYGDRYINLRGPIPAHLLGDMWAQSWENIYDMVVPF
PDKPNLDVTSTMLQQGWNATHMFRVAEEFFTSLELSPMPPEFWEGSMLEKPADGREVVCH
ASAWDFYNRKDFRIKQCTRVTMDQLSTVHHEMGHIQYYLQYKDLPVSLRRGANPGFHEAI
GDVLALSVSTPEHLHKIGLLDRVTNDTESDINYLLKMALEKIAFLPFGYLVDQWRWGVFS
GRTPPSRYNFDWWYLRTKYQGICPPVTRNETHFDAGAKFHVPNVTPYIRYFVSFVLQFQF
HEALCKEAGYEGPLHQCDIYRSTKAGAKLRKVLQAGSSRPWQEVLKDMVGLDALDAQPLL
KYFQPVTQWLQEQNQQNGEVLGWPEYQWHPPLPDNYPEGIDLVTDEAEASKFVEEYDRTS
QVVWNEYAEANWNYNTNITTETSKILLQKNMQIANHTLKYGTQARKFDVNQLQNTTIKRI
IKKVQDLERAALPAQELEEYNKILLDMETTYSVATVCHPNGSCLQLEPDLTNVMATSRKY
EDLLWAWEGWRDKAGRAILQFYPKYVELINQAARLNGYVDAGDSWRSMYETPSLEQDLER
LFQELQPLYLNLHAYVRRALHRHYGAQHINLEGPIPAHLLGNMWAQTWSNIYDLVVPFPS
APSMDTTEAMLKQGWTPRRMFKEADDFFTSLGLLPVPPEFWNKSMLEKPTDGREVVCHAS
AWDFYNGKDFRIKQCTTVNLEDLVVAHHEMGHIQYFMQYKDLPVALREGANPGFHEAIGD
VLALSVSTPKHLHSLNLLSSEGGSDEHDINFLMKMALDKIAFIPFSYLVDQWRWRVFDGS
ITKENYNQEWWSLRLKYQGLCPPVPRTQGDFDPGAKFHIPSSVPYIRYFVSFIIQFQFHE
ALCQAAGHTGPLHKCDIYQSKEAGQRLATAMKLGFSRPWPEAMQLITGQPNMSASAMLSY
FKPLLDWLRTENELHGEKLGWPQYNWTPNSARSEGPLPDSGRVSFLGLDLDAQQARVGQW
LLLFLGIALLVATLGLSQRLFSIRHRSLHRHSHGPQFGSEVELRHS
NT seq
3921 nt
NT seq
+upstream
nt +downstream
nt
atgggggccgcctcgggccgccgggggccggggctgctgctgccgctgccgctgctgttg
ctgctgccgccgcagcccgccctggcgttggaccccgggctgcagcccggcaacttttct
gctgacgaggccggggcgcagctcttcgcgcagagctacaactccagcgccgaacaggtg
ctgttccagagcgtggccgccagctgggcgcacgacaccaacatcaccgcggagaatgca
aggcgccaggaggaagcagccctgctcagccaggagtttgcggaggcctggggccagaag
gccaaggagctgtatgaaccgatctggcagaacttcacggacccgcagctgcgcaggatc
atcggagctgtgcgcaccctgggctctgccaacctgcccctggctaagcggcagcagtac
aacgccctgctaagcaacatgagcaggatctactccaccgccaaggtctgcctccccaac
aagactgccacctgctggtccctggacccagatctcaccaacatcctggcttcctcgcga
agctacgccatgctcctgtttgcctgggagggctggcacaacgctgcgggcatcccgctg
aaaccgctgtacgaggatttcactgccctcagcaatgaagcctacaagcaggacggcttc
acagacacgggggcctactggcgctcctggtacaactcccccaccttcgaggacgatctg
gaacacctctaccaacagctagagcccctctacctgaacctccatgccttcgtccgccgc
gcactgcatcgccgatacggagacagatacatcaacctcaggggacccatccctgctcat
ctgctgggagacatgtgggcccagagctgggaaaacatctacgacatggtggtgcctttc
ccagacaagcccaacctcgatgtcaccagtactatgctgcagcagggctggaacgccacg
cacatgttccgggtggcagaggagttcttcacctccctggagctctcccccatgcctccc
gagttctgggaagggtcgatgctggagaagccggccgacgggcgggaagtggtgtgccac
gcctcggcttgggacttctacaacaggaaagacttcaggatcaagcagtgcacacgggtc
acgatggaccagctctccacagtgcaccatgagatgggccatatacagtactacctgcag
tacaaggatctgcccgtctccctgcgtcggggggccaaccccggcttccatgaggccatt
ggggacgtgctggcgctctcggtctccactcctgaacatctgcacaaaatcggcctgctg
gaccgtgtcaccaatgacacggaaagtgacatcaattacttgctaaaaatggcactggaa
aaaattgccttcctgccctttggctacttggtggaccagtggcgctggggggtctttagt
gggcgtacccccccttcccgctacaacttcgactggtggtatcttcgaaccaagtatcag
gggatctgtcctcctgttacccgaaacgaaacccactttgatgctggagctaagtttcat
gttccaaatgtgacaccatacatcaggtactttgtgagttttgtcctgcagttccagttc
catgaagccctgtgcaaggaggcaggctatgagggcccactgcaccagtgtgacatctac
cggtccaccaaggcaggggccaagctccggaaggtgctgcaggctggctcctccaggccc
tggcaggaggtgctgaaggacatggtcggcttagatgccctggatgcccagccgctgctc
aagtacttccagccagtcacccagtggctgcaggagcagaaccagcagaacggcgaggtc
ctgggctggcccgagtaccagtggcacccgccgttgcctgacaactacccggagggcata
gacctggtgactgatgaggctgaggccagcaagtttgtggaggaatatgaccggacatcc
caggtggtgtggaacgagtatgccgaggccaactggaactacaacaccaacatcaccaca
gagaccagcaagattctgctgcagaagaacatgcaaatagccaaccacaccctgaagtac
ggcacccaggccaggaagtttgatgtgaaccagttgcagaacaccactatcaagcggatc
ataaagaaggttcaggacctagaacgggcagcactgcctgcccaggagctggaggagtac
aacaagatcctgttggatatggaaaccacctacagcgtggccactgtgtgccacccgaat
ggcagctgcctgcagctcgagccagatctgacgaatgtgatggccacgtcccggaaatat
gaagacctgttatgggcatgggagggctggcgagacaaggcggggagagccatcctccag
ttttacccgaaatacgtggaactcatcaaccaggctgcccggctcaatggctatgtagat
gcaggggactcgtggaggtctatgtacgagacaccatccctggagcaagacctggagcgg
ctcttccaggagctgcagccactctacctcaacctgcatgcctacgtgcgccgggccctg
caccgtcactacggggcccagcacatcaacctggaggggcccattcctgctcacctgctg
gggaacatgtgggcgcagacctggtccaacatctatgacttggtggtgcccttcccttca
gccccctcgatggacaccacagaggctatgctaaagcagggctggacgcccaggaggatg
tttaaggaggctgatgatttcttcacctccctggggctgctgcccgtgcctcctgagttc
tggaacaagtcgatgctggagaagccaaccgacgggcgggaggtggtctgccacgcctcg
gcctgggacttctacaacggcaaggacttccggatcaagcagtgcaccaccgtgaacttg
gaggacctggtggtggcccaccacgaaatgggccacatccagtatttcatgcagtacaaa
gacttacctgtggccttgagggagggtgccaaccccggcttccatgaggccattggggac
gtgctagccctctcagtgtctacgcccaagcacctgcacagtctcaacctgctgagcagt
gagggtggcagcgacgagcatgacatcaactttctgatgaagatggcccttgacaagatc
gcctttatccccttcagctacctcgtcgatcagtggcgctggagggtatttgatggaagc
atcaccaaggagaactataaccaggagtggtggagcctcaggctgaagtaccagggcctc
tgccccccagtgcccaggactcaaggtgactttgacccaggggccaagttccacattcct
tctagcgtgccttacatcaggtactttgtcagcttcatcatccagttccagttccacgag
gcactgtgccaggcagctggccacacgggccccctgcacaagtgtgacatctaccagtcc
aaggaggccgggcagcgcctggcgaccgccatgaagctgggcttcagtaggccgtggccg
gaagccatgcagctgatcacgggccagcccaacatgagcgcctcggccatgttgagctac
ttcaagccgctgctggactggctccgcacggagaacgagctgcatggggagaagctgggc
tggccgcagtacaactggacgccgaactccgctcgctcagaagggcccctcccagacagc
ggccgcgtcagcttcctgggcctggacctggatgcgcagcaggcccgcgtgggccagtgg
ctgctgctcttcctgggcatcgccctgctggtagccaccctgggcctcagccagcggctc
ttcagcatccgccaccgcagcctccaccggcactcccacgggccccagttcggctccgag
gtggagctgagacactcctga
DBGET
integrated database retrieval system
