KEGG   DRUG: VedolizumabHelp
Entry
D08083                      Drug                                   

Name
Vedolizumab (USAN);
Vedolizumab (genetical recombination) (JAN);
Entyvio (TN)
Product
Formula
C6428H10072N1732O2042S42
Exact mass
145544.5805
Mol weight
145633.8605
Remark
Therapeutic category: 2399
ATC code: L04AA33
Product: D08083<JP/US>
Efficacy
Anti-inflammatory, Integrin receptor antagonist, Anti-alpha4/beta7 integrin antibody
  Disease
Ulcerative colitis [DS:H01466]
Crohn's disease [DS:H00286]
Comment
Monoclonal antibody
Treatment of ulcerative colitis and Crohn's disease
Target
ITGA4/ITGB7 [HSA:3676 3695] [KO:K06483 K06590]
  Pathway
hsa04512  ECM-receptor interaction
hsa04514  Cell adhesion molecules (CAMs)
Interaction
Drug interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 L ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
  L04 IMMUNOSUPPRESSANTS
   L04A IMMUNOSUPPRESSANTS
    L04AA Selective immunosuppressants
     L04AA33 Vedolizumab
      D08083  Vedolizumab (USAN) <JP/US>
USP drug classification [BR:br08302]
 Immunological Agents
  Immunomodulators
   Vedolizumab
    D08083  Vedolizumab (USAN)
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  23  Digestive organ agents
   239  Miscellaneous
    2399  Others
     D08083  Vedolizumab (USAN); Vedolizumab (genetical recombination) (JAN)
Target-based classification of drugs [BR:br08310]
 Cell surface molecules and ligands
  Cell adhesion molecules: other families
   Integrins
    ITGA4/ITGB7
     D08083  Vedolizumab (USAN) <JP/US>
New drug approvals in the USA [br08319.html]
 New Molecular Entity and New Therapeutic Biological Product Approvals
  D08083
New drug approvals in Europe [br08329.html]
 European public assessment reports (EPAR) authorised medicine
  D08083
New drug approvals in Japan [br08318.html]
 Drugs with new active ingredients
  D08083
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D08083
BRITE hierarchy
Other DBs
CAS: 943609-66-3
PubChem: 96024773
LinkDB All DBs

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