| Entry |
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| Gene name |
ITGB7
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| Definition |
(RefSeq) integrin subunit beta 7
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| KO |
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| Organism |
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| Pathway |
| hsa04672 | Intestinal immune network for IgA production |
| hsa04810 | Regulation of actin cytoskeleton |
| hsa05202 | Transcriptional misregulation in cancer |
| hsa05412 | Arrhythmogenic right ventricular cardiomyopathy |
|
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| Network |
nt06135 Cytoskeletal regulation (viruses and bacteria) nt06167 Human cytomegalovirus (HCMV) nt06240 Transcription |
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| Element |
| N00124 | IGH-MAF fusion to transcriptional activation |
| N00393 | ITGA/B-RhoGAP-RhoA signaling pathway |
| N00951 | ITGA/B-RHOG-RAC signaling pathway |
| N01068 | ITGA/B-FAK-RAC signaling pathway |
| N01070 | ITGA/B-FAK-CDC42 signaling pathway |
| N01072 | ITGA/B-RhoGEF-RhoA signaling pathway |
| N01080 | ITGA/B-TALIN/VINCULIN signaling pathway |
|
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| Drug target |
| Valategrast hydrochloride: | D10028 |
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| Brite |
KEGG Orthology (KO) [BR:hsa00001]
09130 Environmental Information Processing
09132 Signal transduction
04151 PI3K-Akt signaling pathway
3695 (ITGB7)
09133 Signaling molecules and interaction
04512 ECM-receptor interaction
3695 (ITGB7)
04514 Cell adhesion molecules
3695 (ITGB7)
09140 Cellular Processes
09144 Cellular community - eukaryotes
04510 Focal adhesion
3695 (ITGB7)
09142 Cell motility
04810 Regulation of actin cytoskeleton
3695 (ITGB7)
09150 Organismal Systems
09151 Immune system
04672 Intestinal immune network for IgA production
3695 (ITGB7)
09160 Human Diseases
09161 Cancer: overview
05202 Transcriptional misregulation in cancer
3695 (ITGB7)
09172 Infectious disease: viral
05165 Human papillomavirus infection
3695 (ITGB7)
09166 Cardiovascular disease
05410 Hypertrophic cardiomyopathy
3695 (ITGB7)
05412 Arrhythmogenic right ventricular cardiomyopathy
3695 (ITGB7)
05414 Dilated cardiomyopathy
3695 (ITGB7)
09180 Brite Hierarchies
09183 Protein families: signaling and cellular processes
04147 Exosome [BR:hsa04147]
3695 (ITGB7)
04515 Cell adhesion molecules [BR:hsa04515]
3695 (ITGB7)
Exosome [BR:hsa04147]
Exosomal proteins
Exosomal proteins of haemopoietic cells (B-cell, T-cell, DC-cell, reticulocyte, and mast cell)
3695 (ITGB7)
Cell adhesion molecules [BR:hsa04515]
Integrins
Integrin beta subunits
3695 (ITGB7)
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| SSDB |
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| Motif |
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| Other DBs |
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| LinkDB |
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| Structure |
PDB: |
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| Position |
12q13.13
|
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| AA seq |
798 aa
MVALPMVLVLLLVLSRGESELDAKIPSTGDATEWRNPHLSMLGSCQPAPSCQKCILSHPS
CAWCKQLNFTASGEAEARRCARREELLARGCPLEELEEPRGQQEVLQDQPLSQGARGEGA
TQLAPQRVRVTLRPGEPQQLQVRFLRAEGYPVDLYYLMDLSYSMKDDLERVRQLGHALLV
RLQEVTHSVRIGFGSFVDKTVLPFVSTVPSKLRHPCPTRLERCQSPFSFHHVLSLTGDAQ
AFEREVGRQSVSGNLDSPEGGFDAILQAALCQEQIGWRNVSRLLVFTSDDTFHTAGDGKL
GGIFMPSDGHCHLDSNGLYSRSTEFDYPSVGQVAQALSAANIQPIFAVTSAALPVYQELS
KLIPKSAVGELSEDSSNVVQLIMDAYNSLSSTVTLEHSSLPPGVHISYESQCEGPEKREG
KAEDRGQCNHVRINQTVTFWVSLQATHCLPEPHLLRLRALGFSEELIVELHTLCDCNCSD
TQPQAPHCSDGQGHLQCGVCSCAPGRLGRLCECSVAELSSPDLESGCRAPNGTGPLCSGK
GHCQCGRCSCSGQSSGHLCECDDASCERHEGILCGGFGRCQCGVCHCHANRTGRACECSG
DMDSCISPEGGLCSGHGRCKCNRCQCLDGYYGALCDQCPGCKTPCERHRDCAECGAFRTG
PLATNCSTACAHTNVTLALAPILDDGWCKERTLDNQLFFFLVEDDARGTVVLRVRPQEKG
ADHTQAIVLGCVGGIVAVGLGLVLAYRLSVEIYDRREYSRFEKEQQQLNWKQDSNPLYKS
AITTTINPRFQEADSPTL |
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| NT seq |
2397 nt +upstreamnt +downstreamnt
atggtggctttgccaatggtccttgttttgctgctggtcctgagcagaggtgagagtgaa
ttggacgccaagatcccatccacaggggatgccacagaatggcggaatcctcacctgtcc
atgctggggtcctgccagccagccccctcctgccagaagtgcatcctctcacaccccagc
tgtgcatggtgcaagcaactgaacttcaccgcgtcgggagaggcggaggcgcggcgctgc
gcccgacgagaggagctgctggctcgaggctgcccgctggaggagctggaggagccccgc
ggccagcaggaggtgctgcaggaccagccgctcagccagggcgcccgcggagagggtgcc
acccagctggcgccgcagcgggtccgggtcacgctgcggcctggggagccccagcagctc
caggtccgcttccttcgtgctgagggatacccggtggacctgtactaccttatggacctg
agctactccatgaaggacgacctggaacgcgtgcgccagctcgggcacgctctgctggtc
cggctgcaggaagtcacccattctgtgcgcattggttttggttcctttgtggacaaaacg
gtgctgccctttgtgagcacagtaccctccaaactgcgccacccctgccccacccggctg
gagcgctgccagtcaccattcagctttcaccatgtgctgtccctgacgggggacgcacaa
gccttcgagcgggaggtggggcgccagagtgtgtccggcaatctggactcgcctgaaggt
ggcttcgatgccattctgcaggctgcactctgccaggagcagattggctggagaaatgtg
tcccggctgctggtgttcacttcagacgacacattccatacagctggggacgggaagttg
ggcggcattttcatgcccagtgatgggcactgccacttggacagcaatggcctctacagt
cgcagcacagagtttgactacccttctgtgggtcaggtagcccaggccctctctgcagca
aatatccagcccatctttgctgtcaccagtgccgcactgcctgtctaccaggagctgagt
aaactgattcctaagtctgcagttggggagctgagtgaggactccagcaacgtggtacag
ctcatcatggatgcttataatagcctgtcttccaccgtgacccttgaacactcttcactc
cctcctggggtccacatttcttacgaatcccagtgtgagggtcctgagaagagggagggt
aaggctgaggatcgaggacagtgcaaccacgtccgaatcaaccagacggtgactttctgg
gtttctctccaagccacccactgcctcccagagccccatctcctgaggctccgggccctt
ggcttctcagaggagctgattgtggagttgcacacgctgtgtgactgtaattgcagtgac
acccagccccaggctccccactgcagtgatggccagggacacctacaatgtggtgtatgc
agctgtgcccctggccgcctaggtcggctctgtgagtgctctgtggcagagctgtcctcc
ccagacctggaatctgggtgccgggctcccaatggcacagggcccctgtgcagtggaaag
ggtcactgtcaatgtggacgctgcagctgcagtggacagagctctgggcatctgtgcgag
tgtgacgatgccagctgtgagcgacatgagggcatcctctgcggaggctttggtcgctgc
caatgtggagtatgtcactgtcatgccaaccgcacgggcagagcatgcgaatgcagtggg
gacatggacagttgcatcagtcccgagggagggctctgcagtgggcatggacgctgcaaa
tgcaaccgctgccagtgcttggacggctactatggtgctctatgcgaccaatgcccaggc
tgcaagacaccatgcgagagacaccgggactgtgcagagtgtggggccttcaggactggc
ccactggccaccaactgcagtacagcttgtgcccataccaatgtgaccctggccttggcc
cctatcttggatgatggctggtgcaaagagcggaccctggacaaccagctgttcttcttc
ttggtggaggatgacgccagaggcacggtcgtgctcagagtgagaccccaagaaaaggga
gcagaccacacgcaggccattgtgctgggctgcgtagggggcatcgtggcagtggggctg
gggctggtcctggcttaccggctctcggtggaaatctatgaccgccgggaatacagtcgc
tttgagaaggagcagcaacaactcaactggaagcaggacagtaatcctctctacaaaagt
gccatcacgaccaccatcaatcctcgctttcaagaggcagacagtcccactctctga |
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