KEGG   DRUG: MethyldopaHelp
Entry
D08205                      Drug                                   

Name
Methyldopa (INN);
Aldomet (TN)
Formula
C10H13NO4
Exact mass
211.0845
Mol weight
211.2145
Structure
Mol fileKCF fileDB search
Simcomp SIMCOMP
Class
Cardiovascular agent
 DG01738  Centrally-acting antiadrenergic
 DG01456  Adrenergic receptor agonist
  DG01450  alpha-Adrenergic receptor agonist
   DG01449  alpha2-Adrenergic receptor agonist
    DG01655  alpha2-adrenergic receptor specific agonist
 DG01951  Catecholamine adrenergic receptor agonist
Other
 DG01617  Catecholamine synthesis inhibitors
Remark
Same as: C07194
ATC code: C02AB01
Chemical structure group: DG00248
Product (DG00248): D00405<JP/US>
Product (mixture): D10267<US>
Efficacy
Antihypertensive, alpha2-Adrenergic receptor agonist
Comment
Peripheral aromatic L-amino acid decarboxylase inhibitors (DCI)
Dopamine derivative
Target
ADRA2 [HSA:150 151 152] [KO:K04138 K04139 K04140]
  Pathway
hsa04022  cGMP-PKG signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
Interaction
Drug interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 C CARDIOVASCULAR SYSTEM
  C02 ANTIHYPERTENSIVES
   C02A ANTIADRENERGIC AGENTS, CENTRALLY ACTING
    C02AB Methyldopa
     C02AB01 Methyldopa (levorotatory)
      D08205  Methyldopa (INN)
USP drug classification [BR:br08302]
 Cardiovascular Agents
  Alpha-adrenergic Agonists
   Methyldopa
    D08205  Methyldopa (INN)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Adrenaline
    ADRA2
     D08205  Methyldopa (INN)
BRITE hierarchy
Other DBs
CAS: 555-30-6
PubChem: 96024893
ChEBI: 61058
ChEMBL: CHEMBL459
DrugBank: DB00968
LigandBox: D08205
NIKKAJI: J9.247I
LinkDB All DBs
KCF data Show

ATOM        15
            1   C1d C    27.4400  -15.8200
            2   C6a C    28.6300  -15.1200
            3   C1b C    26.2500  -15.1200
            4   C1a C    26.9500  -17.2200
            5   N1a N    28.4200  -17.2200
            6   O6a O    29.8200  -15.8200
            7   O6a O    28.6300  -13.7900
            8   C8y C    25.0600  -15.8200
            9   C8x C    23.8700  -15.1200
            10  C8x C    25.0600  -17.2200
            11  C8y C    22.6800  -15.8200
            12  C8x C    23.8700  -17.8500
            13  C8y C    22.6800  -17.2200
            14  O1a O    21.4900  -15.1200
            15  O1a O    21.4900  -17.8500
BOND        15
            1     1   2 1
            2     1   3 1
            3     1   4 1 #Down
            4     1   5 1 #Up
            5     2   6 1
            6     2   7 2
            7     3   8 1
            8     8   9 1
            9     8  10 2
            10    9  11 2
            11   10  12 1
            12   11  13 1
            13   11  14 1
            14   13  15 1
            15   12  13 2

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