| Entry |
|
|---|
| Name |
Trimazosin (INN) |
|---|
| Formula |
C20H29N5O6
|
|---|
| Exact mass |
435.2118
|
|---|
| Mol weight |
435.47
|
|---|
| Structure |
|
|---|
| Simcomp |
|
|---|
| Class |
Cardiovascular agent
DG01466 Adrenergic receptor antagonist
DG01465 alpha-Adrenergic receptor antagonist
DG01457 alpha1-Adrenergic receptor antagonist
DG01739 Peripherally-acting antiadrenergic
|
|---|
| Remark |
|
|---|
| Efficacy |
Antihypertensive, alpha1-Adrenergic receptor antagonist |
|---|
| Comment |
Prazosin derivative
|
|---|
| Target |
|
|---|
| Pathway |
| hsa04080 | Neuroactive ligand-receptor interaction |
| hsa04261 | Adrenergic signaling in cardiomyocytes |
| hsa04270 | Vascular smooth muscle contraction |
|
|---|
| Interaction |
|
|---|
| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
C CARDIOVASCULAR SYSTEM
C02 ANTIHYPERTENSIVES
C02C ANTIADRENERGIC AGENTS, PERIPHERALLY ACTING
C02CA Alpha-adrenoreceptor antagonists
C02CA03 Trimazosin
D08212 Trimazosin (INN)
Drug groups [BR:br08330]
Cardiovascular agent
DG01466 Adrenergic receptor antagonist
DG01465 alpha-Adrenergic receptor antagonist
DG01457 alpha1-Adrenergic receptor antagonist
DG00255 Trimazosin
D08212 Trimazosin
DG01739 Peripherally-acting antiadrenergic
DG00255 Trimazosin
D08212 Trimazosin
Target-based classification of drugs [BR:br08310]
G Protein-coupled receptors
Rhodopsin family
Adrenaline
ADRA1
D08212 Trimazosin (INN)
Drug groups [BR:br08330]
Cardiovascular agent
DG01466 Adrenergic receptor antagonist
DG01465 alpha-Adrenergic receptor antagonist
DG01457 alpha1-Adrenergic receptor antagonist
DG00255 Trimazosin
DG01739 Peripherally-acting antiadrenergic
DG00255 Trimazosin
|
|---|
| Other DBs |
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| LinkDB |
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| KCF data |
ATOM 31
1 C8y C 29.9600 -20.0900
2 C8y C 29.9600 -18.6900
3 C8x C 31.1500 -20.7900
4 C8y C 28.7700 -20.7900
5 N5x N 28.7700 -17.9900
6 C8y C 31.1500 -17.9900
7 C8y C 32.3400 -20.0900
8 N5x N 27.5100 -20.0900
9 N1a N 28.7700 -22.1900
10 C8y C 27.5100 -18.6900
11 C8y C 32.3400 -18.6900
12 O2a O 33.6000 -20.7900
13 N1y N 26.3200 -17.9900
14 O2a O 33.6000 -17.9900
15 C1a C 34.7900 -20.0900
16 C1x C 26.3200 -16.5900
17 C1x C 25.1300 -18.6900
18 C1a C 34.7900 -18.6900
19 C1x C 25.1300 -15.8900
20 C1x C 23.8700 -17.9900
21 N1y N 23.8700 -16.5900
22 C7a C 22.6800 -15.8900
23 O7a O 21.4200 -16.5900
24 O6a O 22.6800 -14.4900
25 O2a O 31.1500 -16.5900
26 C1a C 32.4100 -15.8900
27 C1b C 20.2300 -15.8900
28 C1d C 19.0400 -16.5900
29 C1a C 17.8500 -17.2900
30 O1a O 18.3400 -15.4000
31 C1a C 19.7400 -17.8500
BOND 33
1 1 2 2
2 1 3 1
3 1 4 1
4 2 5 1
5 2 6 1
6 3 7 2
7 4 8 2
8 4 9 1
9 5 10 2
10 6 11 2
11 7 12 1
12 10 13 1
13 11 14 1
14 12 15 1
15 13 16 1
16 13 17 1
17 14 18 1
18 16 19 1
19 17 20 1
20 19 21 1
21 21 22 1
22 22 23 1
23 22 24 2
24 7 11 1
25 8 10 1
26 20 21 1
27 6 25 1
28 25 26 1
29 23 27 1
30 27 28 1
31 28 29 1
32 28 30 1
33 28 31 1
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|---|
