KEGG   DRUG: MidodrineHelp
Entry
D08220                      Drug                                   

Name
Midodrine (INN)
Formula
C12H18N2O4
Exact mass
254.1267
Mol weight
254.2823
Structure
Mol fileKCF fileDB search
Simcomp SIMCOMP
Class
Cardiovascular agent
 DG01703  Cardiotonic
  DG01702  Phenethylamine cardiotonic
 DG01456  Adrenergic receptor agonist
  DG01450  alpha-Adrenergic receptor agonist
   DG01448  alpha1-Adrenergic receptor agonist
    DG01654  alpha1-Adrenergic receptor specific agonist
Enzyme inhibitor
 DG01645  CYP2D6 inhibitor
Remark
Same as: C07890
ATC code: C01CA17
Chemical structure group: DG00224
Product (DG00224): D01307<JP/US>
Efficacy
Antihypotensive, alpha1-Adrenergic receptor agonist
Comment
Phenethylamine derivative
Active form of prodrug: Deglymidodrine [CPD:C21521]
Target
ADRA1 [HSA:148 147 146] [KO:K04135 K04136 K04137]
  Pathway
hsa04020  Calcium signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04270  Vascular smooth muscle contraction
hsa04970  Salivary secretion
Interaction
CYP inhibition: CYP2D6 [HSA:1565]
Drug interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 C CARDIOVASCULAR SYSTEM
  C01 CARDIAC THERAPY
   C01C CARDIAC STIMULANTS EXCL. CARDIAC GLYCOSIDES
    C01CA Adrenergic and dopaminergic agents
     C01CA17 Midodrine
      D08220  Midodrine (INN)
USP drug classification [BR:br08302]
 Cardiovascular Agents
  Alpha-adrenergic Agonists
   Midodrine
    D08220  Midodrine (INN)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Adrenaline
    ADRA1
     D08220  Midodrine (INN)
Prodrugs [br08324.html]
 D08220
Prodrugs [br08324.html]
 DG00224
BRITE hierarchy
Other DBs
CAS: 42794-76-3
PubChem: 96024908
ChEBI: 6933
ChEMBL: CHEMBL1201212
LigandBox: D08220
NIKKAJI: J16.460G
LinkDB All DBs
KCF data Show

ATOM        18
            1   C8y C    14.0000  -20.5100
            2   C8x C    14.0000  -21.9100
            3   C8x C    15.2124  -22.6100
            4   C8y C    16.4249  -21.9100
            5   C8y C    16.4249  -20.5100
            6   C8x C    15.2124  -19.8100
            7   C1c C    17.6560  -19.7990
            8   C1b C    18.8612  -20.4947
            9   O1a O    17.6557  -18.4101
            10  N1b N    20.0435  -19.8119
            11  C5a C    21.2375  -20.5012
            12  C1b C    22.4254  -19.8152
            13  N1a N    23.6165  -20.5029
            14  O5a O    21.2377  -21.9097
            15  O2a O    12.7876  -19.8100
            16  C1a C    11.5921  -20.5004
            17  O2a O    17.6560  -22.6210
            18  C1a C    17.6560  -24.0210
BOND        18
            1     1   2 2
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 2
            6     1   6 1
            7     5   7 1
            8     7   8 1
            9     7   9 1
            10    8  10 1
            11   10  11 1
            12   11  12 1
            13   12  13 1
            14   11  14 2
            15    1  15 1
            16   15  16 1
            17    4  17 1
            18   17  18 1

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