KEGG   DRUG: NaloxoneHelp
Entry
D08249                      Drug                                   

Name
Naloxone (INN);
DBL Naloxone (TN)
Formula
C19H21NO4
Exact mass
327.1471
Mol weight
327.3743
Structure
Mol fileKCF fileDB search
Simcomp SIMCOMP
Class
Analgesic
 DG01586  Opioid receptor antagonist
Other
 DG01718  Drugs for addictive disorder
  DG01717  Drugs for opioid dependence
Remark
Same as: C07252
ATC code: A06AH04 V03AB15
Chemical structure group: DG01155
Product (DG01155): D01340<JP/US>
Product (mixture): D10250<US>
Efficacy
Narcotic antagonist, Respiratory stimulant, Opioid receptor antagonist
Comment
Normorphine derivative
Target
OPRM1 [HSA:4988] [KO:K04215]
OPRK1 [HSA:4986] [KO:K04214]
OPRD1 [HSA:4985] [KO:K04213]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa05032  Morphine addiction
Interaction
Drug interaction
Structure map
map07039  Opioid analgesics
map07224  Opioid receptor agonists/antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 A ALIMENTARY TRACT AND METABOLISM
  A06 DRUGS FOR CONSTIPATION
   A06A DRUGS FOR CONSTIPATION
    A06AH Peripheral opioid receptor antagonist
     A06AH04 Naloxone
      D08249  Naloxone (INN)
 V VARIOUS
  V03 ALL OTHER THERAPEUTIC PRODUCTS
   V03A ALL OTHER THERAPEUTIC PRODUCTS
    V03AB Antidotes
     V03AB15 Naloxone
      D08249  Naloxone (INN)
USP drug classification [BR:br08302]
 Anti-Addiction/Substance Abuse Treatment Agents
  Opioid Reversal Agents
   Naloxone
    D08249  Naloxone (INN)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Opioid
    OPRM1
     D08249  Naloxone (INN)
    OPRK1
     D08249  Naloxone (INN)
    OPRD1
     D08249  Naloxone (INN)
BRITE hierarchy
Other DBs
CAS: 465-65-6
PubChem: 96024937
ChEBI: 7459
ChEMBL: CHEMBL80
DrugBank: DB01183
LigandBox: D08249
NIKKAJI: J5.894G
LinkDB All DBs
KCF data Show

ATOM        24
            1   C1z C    21.9100  -18.6200
            2   C8y C    21.9100  -17.2900
            3   C1z C    23.1000  -19.2500
            4   C1y C    20.7900  -19.1800
            5   C1x C    23.1000  -17.9900
            6   C8y C    20.7900  -16.6600
            7   C8y C    23.1000  -16.6600
            8   C1y C    24.2200  -18.6200
            9   C1x C    23.1000  -20.5100
            10  O2x O    19.4600  -17.9200
            11  C5x C    20.7900  -20.5100
            12  C1x C    25.3400  -17.9900
            13  C8y C    20.7900  -15.3300
            14  C1x C    24.2200  -17.3600
            15  C8x C    23.1000  -15.3300
            16  N1y N    25.3400  -19.2500
            17  C1x C    21.9100  -21.2100
            18  O5x O    19.6700  -21.2100
            19  C8x C    21.9800  -14.7000
            20  O1a O    19.6700  -14.7000
            21  O1a O    24.3600  -20.1600
            22  C1b C    26.7400  -19.2500
            23  C2b C    27.4400  -20.5100
            24  C2a C    28.8400  -20.5100
BOND        28
            1     1   2 1
            2     1   3 1
            3     1   4 1
            4     1   5 1 #Up
            5     2   6 2
            6     2   7 1
            7     3   8 1
            8     3   9 1
            9     4  10 1 #Down
            10    4  11 1
            11    5  12 1
            12    6  13 1
            13    7  14 1
            14    7  15 2
            15    8  16 1 #Up
            16    9  17 1
            17   11  18 2
            18   13  19 2
            19   13  20 1
            20    6  10 1
            21    8  14 1
            22   11  17 1
            23   12  16 1
            24   15  19 1
            25    3  21 1 #Up
            26   16  22 1
            27   22  23 1
            28   23  24 2

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