KEGG   DRUG: Naloxone
Entry
D08249                      Drug                                   
Name
Naloxone (INN);
DBL Naloxone (TN)
Formula
C19H21NO4
Exact mass
327.1471
Mol weight
327.37
Structure
Simcomp
Class
Analgesic
 DG01586  Opioid receptor antagonist
Remark
Same as: C07252
ATC code: A06AH04 V03AB15
Chemical structure group: DG01155
Product (DG01155): D01340<JP/US> D11620<US>
Product (mixture): D10250<US>
Efficacy
Narcotic antagonist, Respiratory stimulant, Opioid receptor antagonist
Comment
Normorphine derivative
Target
OPRM1 [HSA:4988] [KO:K04215]
OPRK1 [HSA:4986] [KO:K04214]
OPRD1 [HSA:4985] [KO:K04213]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa05032  Morphine addiction
Structure map
map07039  Opioid analgesics
map07224  Opioid receptor agonists/antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 A ALIMENTARY TRACT AND METABOLISM
  A06 DRUGS FOR CONSTIPATION
   A06A DRUGS FOR CONSTIPATION
    A06AH Peripheral opioid receptor antagonists
     A06AH04 Naloxone
      D08249  Naloxone (INN)
 V VARIOUS
  V03 ALL OTHER THERAPEUTIC PRODUCTS
   V03A ALL OTHER THERAPEUTIC PRODUCTS
    V03AB Antidotes
     V03AB15 Naloxone
      D08249  Naloxone (INN)
Drug groups [BR:br08330]
 Analgesic
  DG01586  Opioid receptor antagonist
   DG01155  Naloxone
    D08249  Naloxone
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Opioid
    OPRM1
     D08249  Naloxone (INN)
    OPRK1
     D08249  Naloxone (INN)
    OPRD1
     D08249  Naloxone (INN)
New drug approvals in Europe [br08329.html]
 European public assessment reports (EPAR) authorised medicine
  D08249
Drug groups [BR:br08330]
 Analgesic
  DG01586  Opioid receptor antagonist
   DG01155  Naloxone
Other DBs
CAS: 465-65-6
PubChem: 96024937
ChEBI: 7459
PDB-CCD: A1APV[PDBj]
LigandBox: D08249
NIKKAJI: J5.894G
LinkDB
KCF data

ATOM        24
            1   C1z C    21.9100  -18.6200
            2   C8y C    21.9100  -17.2900
            3   C1z C    23.1000  -19.2500
            4   C1y C    20.7900  -19.1800
            5   C1x C    23.1000  -17.9900
            6   C8y C    20.7900  -16.6600
            7   C8y C    23.1000  -16.6600
            8   C1y C    24.2200  -18.6200
            9   C1x C    23.1000  -20.5100
            10  O2x O    19.4600  -17.9200
            11  C5x C    20.7900  -20.5100
            12  C1x C    25.3400  -17.9900
            13  C8y C    20.7900  -15.3300
            14  C1x C    24.2200  -17.3600
            15  C8x C    23.1000  -15.3300
            16  N1y N    25.3400  -19.2500
            17  C1x C    21.9100  -21.2100
            18  O5x O    19.6700  -21.2100
            19  C8x C    21.9800  -14.7000
            20  O1a O    19.6700  -14.7000
            21  O1a O    24.3600  -20.1600
            22  C1b C    26.7400  -19.2500
            23  C2b C    27.4400  -20.5100
            24  C2a C    28.8400  -20.5100
BOND        28
            1     1   2 1
            2     1   3 1
            3     1   4 1
            4     1   5 1 #Up
            5     2   6 2
            6     2   7 1
            7     3   8 1
            8     3   9 1
            9     4  10 1 #Down
            10    4  11 1
            11    5  12 1
            12    6  13 1
            13    7  14 1
            14    7  15 2
            15    8  16 1 #Up
            16    9  17 1
            17   11  18 2
            18   13  19 2
            19   13  20 1
            20    6  10 1
            21    8  14 1
            22   11  17 1
            23   12  16 1
            24   15  19 1
            25    3  21 1 #Up
            26   16  22 1
            27   22  23 1
            28   23  24 2

» Japanese version   » Back

KEGG   DRUG: Naloxone hydrochloride
Entry
D01340                      Drug                                   
Name
Naloxone hydrochloride (JP18/USP);
Evzio (TN);
Narcan (TN)
Product
EVZIO(R) NALOXONE HCL (HF Acquisition Co LLC), NALOXONE (Summit Biosciences), NALOXONE HYDROCHLORIDE INJECTION, USP, AUTO-INJECTOR (Kaleo), NARCAN (A-S Medication Solutions), NARCAN (Emergent Devices), NARCAN (Proficient Rx LP), NARCAN (RedPharm Drug), NARCAN NALOXONE HCI (HF Acquisition Co LLC), REXTOVY (International Medication Systems), ZIMHI (USWM)
  Generic
NALOXONE HCI (HF Acquisition Co. LLC), NALOXONE HCL (Advanced Rx Pharmacy of Tennessee), NALOXONE HCL (HF Acquisition Co LLC), NALOXONE HYDROCHLORIDE (A-S Medication Solutions), NALOXONE HYDROCHLORIDE (A-S Medication Solutions), NALOXONE HYDROCHLORIDE (A-S Medication Solutions), NALOXONE HYDROCHLORIDE (A-S Medication Solutions), NALOXONE HYDROCHLORIDE (Actavis Pharma), NALOXONE HYDROCHLORIDE (BPI Labs LLC), NALOXONE HYDROCHLORIDE (Baxter Healthcare Corporation), NALOXONE HYDROCHLORIDE (Bryant Ranch Prepack), NALOXONE HYDROCHLORIDE (Civica), NALOXONE HYDROCHLORIDE (Eugia US LLC), NALOXONE HYDROCHLORIDE (Eugia US LLC), NALOXONE HYDROCHLORIDE (Eugia US LLC), NALOXONE HYDROCHLORIDE (Fresenius Kabi USA), NALOXONE HYDROCHLORIDE (HF Acquisition Co LLC), NALOXONE HYDROCHLORIDE (HF Acquisition Co LLC), NALOXONE HYDROCHLORIDE (HF Acquisition Co LLC), NALOXONE HYDROCHLORIDE (HF Acquisition Co LLC), NALOXONE HYDROCHLORIDE (HF Acquisition Co. LLC), NALOXONE HYDROCHLORIDE (HF Acquisition Co. LLC), NALOXONE HYDROCHLORIDE (Henry Schein), NALOXONE HYDROCHLORIDE (Henry Schein), NALOXONE HYDROCHLORIDE (Henry Schein), NALOXONE HYDROCHLORIDE (Henry Schein), NALOXONE HYDROCHLORIDE (Hikma Pharmaceuticals USA), NALOXONE HYDROCHLORIDE (Hikma Pharmaceuticals USA), NALOXONE HYDROCHLORIDE (Hikma Pharmaceuticals USA), NALOXONE HYDROCHLORIDE (Hospira), NALOXONE HYDROCHLORIDE (Hospira), NALOXONE HYDROCHLORIDE (International Medication Systems), NALOXONE HYDROCHLORIDE (International Medication Systems), NALOXONE HYDROCHLORIDE (Lifestar Pharma LLC), NALOXONE HYDROCHLORIDE (Medical Purchasing Solutions), NALOXONE HYDROCHLORIDE (Medical Purchasing Solutions), NALOXONE HYDROCHLORIDE (Medical Purchasing Solutions), NALOXONE HYDROCHLORIDE (Medical Purchasing Solutions), NALOXONE HYDROCHLORIDE (Medical Purchasing Solutions), NALOXONE HYDROCHLORIDE (Medical Purchasing Solutions), NALOXONE HYDROCHLORIDE (Medical Purchasing Solutions), NALOXONE HYDROCHLORIDE (Medical Purchasing Solutions), NALOXONE HYDROCHLORIDE (Mylan Institutional LLC), NALOXONE HYDROCHLORIDE (Mylan Institutional LLC), NALOXONE HYDROCHLORIDE (Mylan Institutional LLC), NALOXONE HYDROCHLORIDE (Mylan Institutional LLC), NALOXONE HYDROCHLORIDE (Mylan Institutional LLC), NALOXONE HYDROCHLORIDE (Mylan Institutional LLC), NALOXONE HYDROCHLORIDE (NorthStar RxLLC), NALOXONE HYDROCHLORIDE (Padagis Israel Pharmaceuticals), NALOXONE HYDROCHLORIDE (Proficient Rx LP), NALOXONE HYDROCHLORIDE (Quality Care Products), NALOXONE HYDROCHLORIDE (Quality Care Products), NALOXONE HYDROCHLORIDE (RedPharm Drug), NALOXONE HYDROCHLORIDE (Somerset Therapeutics), NALOXONE HYDROCHLORIDE (Somerset Therapeutics)
Formula
C19H21NO4. HCl
Exact mass
363.1237
Mol weight
363.83
Structure
Simcomp
Class
Analgesic
 DG01586  Opioid receptor antagonist
Remark
Therapeutic category: 2219
ATC code: A06AH04 V03AB15
Chemical structure group: DG01155
Product (DG01155): D01340<JP/US> D11620<US>
Product (mixture): D10250<US> D12492<US>
Efficacy
Respiratory stimulant, Opioid receptor antagonist
Comment
Normorphine derivative
Target
OPRM1 [HSA:4988] [KO:K04215]
OPRK1 [HSA:4986] [KO:K04214]
OPRD1 [HSA:4985] [KO:K04213]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa05032  Morphine addiction
Structure map
map07039  Opioid analgesics
map07224  Opioid receptor agonists/antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 A ALIMENTARY TRACT AND METABOLISM
  A06 DRUGS FOR CONSTIPATION
   A06A DRUGS FOR CONSTIPATION
    A06AH Peripheral opioid receptor antagonists
     A06AH04 Naloxone
      D01340  Naloxone hydrochloride (JP18/USP) <JP/US>
 V VARIOUS
  V03 ALL OTHER THERAPEUTIC PRODUCTS
   V03A ALL OTHER THERAPEUTIC PRODUCTS
    V03AB Antidotes
     V03AB15 Naloxone
      D01340  Naloxone hydrochloride (JP18/USP) <JP/US>
USP drug classification [BR:br08302]
 Anti-Addiction/Substance Abuse Treatment Agents
  Opioid Reversal Agents
   Naloxone
    D01340  Naloxone hydrochloride (JP18/USP)
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  22  Respiratory organ agents
   221  Respiratory stimulants
    2219  Others
     D01340  Naloxone hydrochloride (JP18/USP)
Drug groups [BR:br08330]
 Analgesic
  DG01586  Opioid receptor antagonist
   DG01155  Naloxone
    D01340  Naloxone hydrochloride
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Opioid
    OPRM1
     D01340  Naloxone hydrochloride (JP18/USP) <JP/US>
    OPRK1
     D01340  Naloxone hydrochloride (JP18/USP) <JP/US>
    OPRD1
     D01340  Naloxone hydrochloride (JP18/USP) <JP/US>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D01340  Naloxone hydrochloride
Rx-to-OTC switch list in the USA [br08315.html]
 D01340
Drug groups [BR:br08330]
 Analgesic
  DG01586  Opioid receptor antagonist
   DG01155  Naloxone
Other DBs
CAS: 357-08-4
PubChem: 7848403
ChEBI: 31892
LigandBox: D01340
NIKKAJI: J219.954H
LinkDB
KCF data

ATOM        25
            1   X   Cl   21.7908  -14.2119
            2   C1z C    14.0948  -15.5899
            3   C8y C    14.0948  -14.2668
            4   C1z C    15.2786  -16.2861
            5   C1y C    12.9806  -16.2166
            6   C1x C    15.2786  -14.9632
            7   C8y C    12.9806  -13.6401
            8   C8y C    15.2786  -13.6401
            9   C1y C    16.3927  -15.5899
            10  C1x C    15.2786  -17.5396
            11  O2x O    11.6576  -14.8934
            12  C5x C    12.9806  -17.5396
            13  C1x C    17.5068  -14.9632
            14  C8y C    12.9806  -12.3171
            15  C1x C    16.3927  -14.3364
            16  C8x C    15.2786  -12.3171
            17  N1y N    17.5068  -16.2861
            18  C1x C    14.0948  -18.2359
            19  O5x O    11.8665  -18.2359
            20  C8x C    14.1644  -11.6904
            21  O1a O    11.8665  -11.6904
            22  O1a O    16.5319  -17.1914
            23  C1b C    18.9047  -16.2861
            24  C2b C    19.6072  -17.5026
            25  C2a C    21.0000  -17.5025
BOND        28
            1     2   3 1
            2     2   4 1
            3     2   5 1
            4     2   6 1 #Up
            5     3   7 2
            6     3   8 1
            7     4   9 1
            8     4  10 1
            9     5  11 1 #Down
            10    5  12 1
            11    6  13 1
            12    7  14 1
            13    8  15 1
            14    8  16 2
            15    9  17 1 #Up
            16   10  18 1
            17   12  19 2
            18   14  20 2
            19   14  21 1
            20    7  11 1
            21    9  15 1
            22   12  18 1
            23   13  17 1
            24   16  20 1
            25    4  22 1 #Up
            26   17  23 1
            27   23  24 1
            28   24  25 2

» Japanese version   » Back

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