KEGG   DRUG: PhenylephrineHelp
Entry
D08365                      Drug                                   

Name
Phenylephrine (INN);
Phenylephrine Minims (TN)
Formula
C9H13NO2
Exact mass
167.0946
Mol weight
167.205
Structure
Mol fileKCF fileDB search
Simcomp SIMCOMP
Class
Cardiovascular agent
 DG01703  Cardiotonic
  DG01702  Phenethylamine cardiotonic
 DG01456  Adrenergic receptor agonist
  DG01450  alpha-Adrenergic receptor agonist
   DG01448  alpha1-Adrenergic receptor agonist
    DG01654  alpha1-Adrenergic receptor specific agonist
Remark
Same as: C07441
ATC code: C01CA06 R01AA04 R01AB01 R01BA03 S01FB01 S01GA05
Chemical structure group: DG00215
Product (DG00215): D00511<JP/US>
Product (mixture): D10837<US>
Efficacy
Vasoconstrictor, alpha1-Adrenergic receptor agonist
Comment
Phenethylamine derivative
Target
ADRA1 [HSA:148 147 146] [KO:K04135 K04136 K04137]
  Pathway
hsa04020  Calcium signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04261  Adrenergic signaling in cardiomyocytes
hsa04270  Vascular smooth muscle contraction
Interaction
Drug interaction
Structure map
map07215  alpha-Adrenergic receptor agonists/antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 C CARDIOVASCULAR SYSTEM
  C01 CARDIAC THERAPY
   C01C CARDIAC STIMULANTS EXCL. CARDIAC GLYCOSIDES
    C01CA Adrenergic and dopaminergic agents
     C01CA06 Phenylephrine
      D08365  Phenylephrine (INN)
 R RESPIRATORY SYSTEM
  R01 NASAL PREPARATIONS
   R01A DECONGESTANTS AND OTHER NASAL PREPARATIONS FOR TOPICAL USE
    R01AA Sympathomimetics, plain
     R01AA04 Phenylephrine
      D08365  Phenylephrine (INN)
    R01AB Sympathomimetics, combinations excl. corticosteroids
     R01AB01 Phenylephrine
      D08365  Phenylephrine (INN)
   R01B NASAL DECONGESTANTS FOR SYSTEMIC USE
    R01BA Sympathomimetics
     R01BA03 Phenylephrine
      D08365  Phenylephrine (INN)
 S SENSORY ORGANS
  S01 OPHTHALMOLOGICALS
   S01F MYDRIATICS AND CYCLOPLEGICS
    S01FB Sympathomimetics excl. antiglaucoma preparations
     S01FB01 Phenylephrine
      D08365  Phenylephrine (INN)
   S01G DECONGESTANTS AND ANTIALLERGICS
    S01GA Sympathomimetics used as decongestants
     S01GA05 Phenylephrine
      D08365  Phenylephrine (INN)
USP drug classification [BR:br08302]
 Cardiovascular Agents
  Alpha-adrenergic Agonists
   Phenylephrine
    D08365  Phenylephrine (INN)
Risk category of Japanese OTC drugs [BR:br08312]
 Second-class OTC drugs
  Inorganic and organic chemicals
   Phenylephrine
    D08365  Phenylephrine (INN)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Adrenaline
    ADRA1
     D08365  Phenylephrine (INN)
BRITE hierarchy
Other DBs
CAS: 59-42-7
PubChem: 96025051
ChEBI: 8093
ChEMBL: CHEMBL1215
DrugBank: DB00388
LigandBox: D08365
NIKKAJI: J8.601K
LinkDB All DBs
KCF data Show

ATOM        12
            1   C8y C    13.1600  -38.5700
            2   C8x C    13.1600  -39.9700
            3   C8x C    14.3724  -40.6700
            4   C8x C    15.5849  -39.9700
            5   C8y C    15.5849  -38.5700
            6   C8x C    14.3724  -37.8700
            7   O1a O    11.9476  -37.8700
            8   C1c C    16.8160  -37.8590
            9   C1b C    18.0212  -38.5547
            10  O1a O    16.8157  -36.4701
            11  N1b N    19.2035  -37.8719
            12  C1a C    20.3975  -38.5612
BOND        12
            1     1   2 2
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 2
            6     1   6 1
            7     1   7 1
            8     5   8 1
            9     8   9 1
            10    8  10 1 #Up
            11    9  11 1
            12   11  12 1

» Japanese version   » Back

DBGET integrated database retrieval system