KEGG   DRUG: PioglitazoneHelp
Entry
D08378                      Drug                                   

Name
Pioglitazone (INN);
Actos (TN)
Formula
C19H20N2O3S
Exact mass
356.1195
Mol weight
356.4387
Structure
Mol fileKCF fileDB search
Simcomp SIMCOMP
Class
Antidiabetic agent
 DG01685  Insulin sensitizer
  DG01795  PPAR gamma agonist
   DG01683  Thiazolidinedione
 DG02044  Hypoglycemics
  DG01683  Thiazolidinedione
Other
 DG01733  PPAR agonist
  DG01683  Thiazolidinedione
Enzyme inducer
 DG02853  CYP3A inducer
 DG01897  CYP3A5 inducer
Remark
Same as: C07675
ATC code: A10BG03
Chemical structure group: DG00117
Product (DG00117): D00945<JP/US>
Product (mixture): D09848<JP/US> D09744<JP/US>
Efficacy
Antidiabetic, Peroxisome proliferator-activated receptor (PPAR) gamma agonist
Comment
Thiazolidinedione derivative
Target
NR1C3 (PPARG) [HSA:5468] [KO:K08530]
  Pathway
hsa03320  PPAR signaling pathway
hsa04152  AMPK signaling pathway
Interaction
CYP induction: CYP3A [HSA:1576 1577 1551]
Drug interaction
Structure map
map07051  Antidiabetics
map07222  Peroxisome proliferator-activated receptor (PPAR) agonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 A ALIMENTARY TRACT AND METABOLISM
  A10 DRUGS USED IN DIABETES
   A10B BLOOD GLUCOSE LOWERING DRUGS, EXCL. INSULINS
    A10BG Thiazolidinediones
     A10BG03 Pioglitazone
      D08378  Pioglitazone (INN)
USP drug classification [BR:br08302]
 Blood Glucose Regulators
  Antidiabetic Agents
   Pioglitazone
    D08378  Pioglitazone (INN)
Target-based classification of drugs [BR:br08310]
 Nuclear receptors
  Thyroid hormone like receptors
   Peroxisome proliferator-activated receptor (PPAR)
    NR1C3 (PPARG)
     D08378  Pioglitazone (INN)
BRITE hierarchy
Other DBs
CAS: 111025-46-8
PubChem: 96025064
ChEBI: 8228
ChEMBL: CHEMBL595
DrugBank: DB01132
LigandBox: D08378
NIKKAJI: J866.288F
LinkDB All DBs
KCF data Show

ATOM        25
            1   C1y C    32.9700  -20.3700
            2   C1b C    31.7800  -19.6700
            3   C8y C    30.5900  -20.3700
            4   C8x C    29.3300  -19.6700
            5   C8x C    30.5900  -21.7700
            6   C8x C    28.1400  -20.3700
            7   C8x C    29.3300  -22.4700
            8   C8y C    28.1400  -21.7700
            9   O2a O    26.9500  -22.4700
            10  C1b C    25.6900  -21.7700
            11  C1b C    24.5700  -22.4700
            12  C8y C    23.3800  -21.7700
            13  C8x C    23.3800  -20.3700
            14  N5x N    22.1900  -22.4700
            15  C8x C    22.1900  -19.6700
            16  C8x C    20.9300  -21.7700
            17  C8y C    20.9300  -20.3700
            18  C1b C    19.7400  -19.6700
            19  C1a C    18.5500  -20.3700
            20  C5x C    32.9698  -21.7700
            21  N1x N    34.3013  -22.2028
            22  C5x C    35.1243  -21.0703
            23  S2x S    34.3015  -19.9375
            24  O5x O    36.5400  -21.0704
            25  O5x O    31.8372  -22.5927
BOND        27
            1     1   2 1
            2     2   3 1
            3     3   4 2
            4     3   5 1
            5     4   6 1
            6     5   7 2
            7     6   8 2
            8     8   9 1
            9     9  10 1
            10   10  11 1
            11   11  12 1
            12   12  13 2
            13   12  14 1
            14   13  15 1
            15   14  16 2
            16   15  17 2
            17   17  18 1
            18   18  19 1
            19    7   8 1
            20   16  17 1
            21    1  20 1
            22   20  21 1
            23   21  22 1
            24   22  23 1
            25    1  23 1
            26   22  24 2
            27   20  25 2

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