KEGG   DRUG: PipotiazineHelp
Entry
D08385                      Drug                                   

Name
Pipotiazine (INN);
Piportil (TN)
Formula
C24H33N3O3S2
Exact mass
475.1963
Mol weight
475.6671
Structure
Mol fileKCF fileDB search
Class
Neuropsychiatric agent
 DG01905  Phenothiazine antipsychotics
Remark
ATC code: N05AC04
Chemical structure group: DG00884
Efficacy
Antipsychotic, Neuroleptic
Comment
Phenothiazine derivative
Target
DRD2 [HSA:1813] [KO:K04145]
DRD1 [HSA:1812] [KO:K04144]
HTR2A [HSA:3356] [KO:K04157]
HTR1A [HSA:3350] [KO:K04153]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04726  Serotonergic synapse
hsa04728  Dopaminergic synapse
Interaction
Drug interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N05 PSYCHOLEPTICS
   N05A ANTIPSYCHOTICS
    N05AC Phenothiazines with piperidine structure
     N05AC04 Pipotiazine
      D08385  Pipotiazine (INN)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Dopamine
    DRD1
     D08385  Pipotiazine (INN)
    DRD2
     D08385  Pipotiazine (INN)
   Serotonin
    HTR1A
     D08385  Pipotiazine (INN)
    HTR2A
     D08385  Pipotiazine (INN)
BRITE hierarchy
Other DBs
CAS: 39860-99-6
PubChem: 96025071
ChEMBL: CHEMBL398880
DrugBank: DB01621
LigandBox: D08385
NIKKAJI: J16.029F
LinkDB All DBs
KCF data Show

ATOM        32
            1   C8x C    14.2800  -22.4700
            2   C8x C    15.4700  -21.7700
            3   C8y C    15.4700  -20.3700
            4   C8x C    14.2800  -19.6700
            5   C8y C    13.0900  -21.7700
            6   C8y C    13.0900  -20.3700
            7   N1y N    11.9000  -19.6700
            8   S2x S    11.9000  -22.4700
            9   C8y C    10.7100  -21.7700
            10  C8y C    10.7100  -20.3700
            11  C8x C     9.4500  -19.6700
            12  C8x C     8.2600  -20.3700
            13  C8x C     8.2600  -21.7700
            14  C8x C     9.4500  -22.4700
            15  C1b C    11.9000  -18.2700
            16  C1b C    13.0900  -17.5700
            17  C1b C    13.0900  -16.2400
            18  N1y N    14.2800  -15.5400
            19  C1x C    15.4700  -16.1700
            20  C1x C    16.6600  -15.5400
            21  C1y C    16.6600  -14.1400
            22  C1x C    15.4700  -13.4400
            23  C1x C    14.2800  -14.1400
            24  C1b C    17.8500  -13.4400
            25  C1b C    19.1100  -14.1400
            26  O1a O    20.3000  -13.4400
            27  S4a S    16.7300  -19.6700
            28  N1c N    17.9200  -20.3700
            29  C1a C    19.1100  -19.6700
            30  C1a C    17.9200  -21.7700
            31  O3c O    17.7100  -18.6900
            32  O3c O    15.6800  -18.6900
BOND        35
            1    23  18 1
            2     1   2 2
            3    21  24 1
            4     2   3 1
            5    24  25 1
            6     9  10 2
            7    25  26 1
            8    10  11 1
            9    11  12 2
            10   12  13 1
            11   13  14 2
            12   14   9 1
            13    3  27 1
            14    5   6 2
            15   27  28 1
            16    7  15 1
            17   28  29 1
            18    6   7 1
            19   28  30 1
            20   15  16 1
            21   27  31 2
            22    7  10 1
            23   27  32 2
            24   16  17 1
            25    9   8 1
            26   17  18 1
            27    8   5 1
            28    3   4 2
            29    4   6 1
            30    5   1 1
            31   18  19 1
            32   19  20 1
            33   20  21 1
            34   21  22 1
            35   22  23 1

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