KEGG   DRUG: Pramocaine
Entry
D08407                      Drug                                   

Name
Pramocaine (INN)
Formula
C17H27NO3
Exact mass
293.1991
Mol weight
293.4012
Structure
Simcomp
Remark
Same as: C07892
ATC code: C05AD07 D04AB07
Chemical structure group: DG00300
Efficacy
Anesthetic (local)
Target
SCN1A [HSA:6323] [KO:K04833]
SCN2A [HSA:6326] [KO:K04834]
SCN3A [HSA:6328] [KO:K04836]
SCN4A [HSA:6329] [KO:K04837]
SCN5A [HSA:6331] [KO:K04838]
SCN8A [HSA:6334] [KO:K04840]
SCN9A [HSA:6335] [KO:K04841]
SCN10A [HSA:6336] [KO:K04842]
SCN11A [HSA:11280] [KO:K04843]
  Pathway
hsa04728  Dopaminergic synapse
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 C CARDIOVASCULAR SYSTEM
  C05 VASOPROTECTIVES
   C05A AGENTS FOR TREATMENT OF HEMORRHOIDS AND ANAL FISSURES FOR TOPICAL USE
    C05AD Local anesthetics
     C05AD07 Pramocaine
      D08407  Pramocaine (INN)
 D DERMATOLOGICALS
  D04 ANTIPRURITICS, INCL. ANTIHISTAMINES, ANESTHETICS, ETC.
   D04A ANTIPRURITICS, INCL. ANTIHISTAMINES, ANESTHETICS, ETC.
    D04AB Anesthetics for topical use
     D04AB07 Pramocaine
      D08407  Pramocaine (INN)
Target-based classification of drugs [BR:br08310]
 Ion channels
  Voltage-gated ion channels
   Sodium channels
    SCN1A
     D08407  Pramocaine (INN)
    SCN2A
     D08407  Pramocaine (INN)
    SCN3A
     D08407  Pramocaine (INN)
    SCN4A
     D08407  Pramocaine (INN)
    SCN5A
     D08407  Pramocaine (INN)
    SCN8A
     D08407  Pramocaine (INN)
    SCN9A
     D08407  Pramocaine (INN)
    SCN10A
     D08407  Pramocaine (INN)
    SCN11A
     D08407  Pramocaine (INN)
Other DBs
CAS: 140-65-8
PubChem: 96025093
ChEBI: 8357
ChEMBL: CHEMBL1198
PDB-CCD: PX9[PDBj]
LigandBox: D08407
NIKKAJI: J5.793B
LinkDB
KCF data

ATOM        21
            1   C8y C    24.2200  -18.3400
            2   C8x C    24.2200  -19.7400
            3   C8x C    22.9600  -17.6400
            4   O2a O    25.4100  -17.6400
            5   C8x C    22.9600  -20.4400
            6   C8x C    21.7700  -18.3400
            7   C1b C    26.6000  -18.3400
            8   C8y C    21.7700  -19.7400
            9   C1b C    27.8600  -17.6400
            10  O2a O    20.5800  -20.4400
            11  C1b C    29.0500  -18.2700
            12  C1b C    19.3200  -19.7400
            13  N1y N    30.2400  -17.5700
            14  C1b C    18.1300  -20.4400
            15  C1x C    31.4300  -18.2700
            16  C1x C    30.2400  -16.1700
            17  C1b C    16.9400  -19.7400
            18  C1x C    32.6900  -17.5700
            19  C1x C    31.4300  -15.4700
            20  C1a C    15.6800  -20.4400
            21  O2x O    32.6900  -16.1700
BOND        22
            1     1   2 1
            2     1   3 2
            3     1   4 1
            4     2   5 2
            5     3   6 1
            6     4   7 1
            7     5   8 1
            8     7   9 1
            9     8  10 1
            10    9  11 1
            11   10  12 1
            12   11  13 1
            13   12  14 1
            14   13  15 1
            15   13  16 1
            16   14  17 1
            17   15  18 1
            18   16  19 1
            19   17  20 1
            20   18  21 1
            21    6   8 2
            22   19  21 1

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