| Entry |
|
|---|
| Name |
Ramosetron hydrochloride (JAN);
YM 060;
Nasea (TN);
Irribow (TN) |
|---|
| Formula |
C17H17N3O. HCl
|
|---|
| Exact mass |
315.1138
|
|---|
| Mol weight |
315.80
|
|---|
| Structure |
|
|---|
| Simcomp |
|
|---|
| Class |
Gastrointestinal agent
DG01489 5-HT3-receptor antagonist
DG01762 Antiemetic
Metabolizing enzyme substrate
DG01892 CYP1A2 substrate
DG01644 CYP2D6 substrate
|
|---|
| Remark |
| Product (DG01239): | D02016<JP> |
|
|---|
| Efficacy |
Anti-emetic, Serotonin 5-HT3 receptor antagonist |
|---|
| Target |
|
|---|
| Pathway |
|
|---|
| Metabolism |
Enzyme: CYP1A2 [HSA: 1544], CYP2D6 [HSA: 1565]
|
|---|
| Interaction |
|
|---|
| Structure map |
| map07211 | Serotonin receptor agonists/antagonists |
|
|---|
| Brite |
Therapeutic category of drugs in Japan [BR:br08301]
2 Agents affecting individual organs
23 Digestive organ agents
239 Miscellaneous
2391 Antiemetics
D02016 Ramosetron hydrochloride (JAN)
2399 Others
D02016 Ramosetron hydrochloride (JAN)
Drug groups [BR:br08330]
Gastrointestinal agent
DG01489 5-HT3-receptor antagonist
DG01239 Ramosetron
D02016 Ramosetron hydrochloride
DG01762 Antiemetic
DG01239 Ramosetron
D02016 Ramosetron hydrochloride
Metabolizing enzyme substrate
DG01892 CYP1A2 substrate
DG01239 Ramosetron
D02016 Ramosetron hydrochloride
DG01644 CYP2D6 substrate
DG01239 Ramosetron
D02016 Ramosetron hydrochloride
Target-based classification of drugs [BR:br08310]
Ion channels
Ligand-gated ion channels
Serotonin
HTR3
D02016 Ramosetron hydrochloride (JAN) <JP>
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
D02016
Drug groups [BR:br08330]
Gastrointestinal agent
DG01489 5-HT3-receptor antagonist
DG01239 Ramosetron
DG01762 Antiemetic
DG01239 Ramosetron
Metabolizing enzyme substrate
DG01892 CYP1A2 substrate
DG01239 Ramosetron
DG01644 CYP2D6 substrate
DG01239 Ramosetron
|
|---|
| Other DBs |
|
|---|
| LinkDB |
|
|---|
| KCF data |
ATOM 22
1 X Cl 21.3413 -6.1250
2 C1x C 12.9500 -3.9900
3 C1y C 12.9500 -5.3900
4 C5a C 14.1624 -6.0900
5 C8y C 15.3749 -5.3900
6 C8x C 15.3749 -3.9900
7 C1x C 11.7376 -3.2900
8 C8y C 10.5251 -3.9900
9 C8y C 10.5251 -5.3900
10 C1x C 11.7376 -6.0900
11 C8y C 16.7064 -5.8226
12 C8y C 17.5293 -4.6900
13 N4y N 16.7064 -3.5574
14 C8x C 17.2758 -7.1016
15 C8x C 18.6681 -7.2479
16 C8x C 19.4911 -6.1153
17 C8x C 18.9216 -4.8363
18 O5a O 14.1624 -7.4900
19 N5x N 9.1936 -3.5574
20 C8x C 8.3707 -4.6900
21 N4x N 9.1936 -5.8226
22 C1a C 17.4064 -2.3449
BOND 24
1 2 3 1
2 3 4 1 #Up
3 4 5 1
4 5 6 2
5 2 7 1
6 7 8 1
7 8 9 2
8 9 10 1
9 3 10 1
10 5 11 1
11 11 12 2
12 12 13 1
13 6 13 1
14 11 14 1
15 14 15 2
16 15 16 1
17 16 17 2
18 12 17 1
19 4 18 2
20 8 19 1
21 19 20 2
22 20 21 1
23 9 21 1
24 13 22 1
|
|---|
