KEGG   DRUG: RemifentanilHelp
Entry
D08473                      Drug                                   

Name
Remifentanil (INN);
Ultiva (TN)
Formula
C20H28N2O5
Exact mass
376.1998
Mol weight
376.4467
Structure
Mol fileKCF fileDB search
Simcomp SIMCOMP
Class
Neuropsychiatric agent
 DG02030  Anesthetics
  DG02027  General anesthetics
   DG02026  Opioid anesthetics
 DG02027  General anesthetics
  DG02026  Opioid anesthetics
 DG01564  Opioid receptor agonist
  DG01563  mu-Opioid receptor agonist
Remark
Same as: C08021
ATC code: N01AH06
Chemical structure group: DG00795
Product (DG00795): D01177<JP/US>
Efficacy
Analgesic (narcotic), Opioid receptor agonist
Comment
Phenylpiperidine derivative
Target
OPRM1 [HSA:4988] [KO:K04215]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
Interaction
Drug interaction
Structure map
map07224  Opioid receptor agonists/antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N01 ANESTHETICS
   N01A ANESTHETICS, GENERAL
    N01AH Opioid anesthetics
     N01AH06 Remifentanil
      D08473  Remifentanil (INN)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Opioid
    OPRM1
     D08473  Remifentanil (INN)
BRITE hierarchy
Other DBs
CAS: 132875-61-7
PubChem: 96025159
ChEBI: 8802
ChEMBL: CHEMBL1005
DrugBank: DB00899
LigandBox: D08473
NIKKAJI: J423.836B
LinkDB All DBs
KCF data Show

ATOM        27
            1   C8x C    16.4500  -27.3700
            2   C8x C    16.4500  -28.7700
            3   C8x C    17.6400  -29.4700
            4   C8x C    18.9000  -28.7700
            5   C8y C    18.9000  -27.3700
            6   C8x C    17.6400  -26.6700
            7   N1c N    20.0900  -26.6700
            8   C1z C    21.3500  -27.3700
            9   C1x C    21.3500  -28.7700
            10  C1x C    22.5400  -29.4700
            11  N1y N    23.7300  -28.7700
            12  C1x C    23.7300  -27.3700
            13  C1x C    22.5400  -26.6700
            14  C1b C    24.9900  -29.4700
            15  C1b C    26.1800  -28.7700
            16  C7a C    27.3700  -29.4700
            17  C5a C    20.0900  -25.2700
            18  O5a O    18.9000  -24.5700
            19  C1b C    21.3500  -24.5700
            20  C1a C    22.5400  -25.2700
            21  C7a C    20.7200  -28.1400
            22  O7a O    28.5881  -28.7799
            23  C1a C    29.7695  -29.4750
            24  O6a O    27.3586  -30.8700
            25  O7a O    20.7200  -29.5400
            26  O6a O    19.5666  -27.8142
            27  C1a C    19.5076  -30.2400
BOND        28
            1     1   2 2
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 2
            6     1   6 1
            7     5   7 1
            8     7   8 1
            9     8   9 1
            10    9  10 1
            11   10  11 1
            12   11  12 1
            13   12  13 1
            14    8  13 1
            15   11  14 1
            16   14  15 1
            17   15  16 1
            18    7  17 1
            19   17  18 2
            20   17  19 1
            21   19  20 1
            22    8  21 1
            23   16  22 1
            24   22  23 1
            25   16  24 2
            26   21  25 1
            27   21  26 2
            28   25  27 1

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