KEGG   DRUG: TrihexyphenidylHelp
Entry
D08638                      Drug                                   

Name
Trihexyphenidyl (INN);
Apo-trihex (TN)
Formula
C20H31NO
Exact mass
301.2406
Mol weight
301.4662
Structure
Mol fileKCF fileDB search
Simcomp SIMCOMP
Class
Neuropsychiatric agent
 DG01491  Muscarinic cholinergic receptor antagonist
 DG01745  Anticholinergic antiparkinson agent
 DG01967  Antiparkinson agent
  DG01745  Anticholinergic antiparkinson agent
Remark
Same as: C07171
ATC code: N04AA01
Chemical structure group: DG00851
Product (DG00851): D00787<JP/US>
Efficacy
Antiparkinsonian, Muscarinic acetylcholine receptor antagonist
Comment
centrally active anticholinergic drugs
Target
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04725  Cholinergic synapse
Interaction
Drug interaction
Structure map
map07057  Antiparkinsonian agents
map07220  Cholinergic and anticholinergic drugs
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N04 ANTI-PARKINSON DRUGS
   N04A ANTICHOLINERGIC AGENTS
    N04AA Tertiary amines
     N04AA01 Trihexyphenidyl
      D08638  Trihexyphenidyl (INN)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Acetylcholine (muscarinic)
    CHRM
     D08638  Trihexyphenidyl (INN)
BRITE hierarchy
Other DBs
CAS: 144-11-6
PubChem: 96025321
ChEBI: 9720
ChEMBL: CHEMBL1490
DrugBank: DB00376
LigandBox: D08638
NIKKAJI: J5.826B
LinkDB All DBs
KCF data Show

ATOM        22
            1   C8x C    22.2262  -19.7138
            2   C8x C    23.4847  -19.0147
            3   C8x C    23.4846  -17.6164
            4   C8x C    22.2262  -16.8473
            5   C8y C    21.0376  -17.5465
            6   C8x C    21.0376  -19.0147
            7   C1x C    20.9676  -14.8198
            8   C1y C    19.7791  -15.5190
            9   C1d C    19.7792  -16.8473
            10  C1x C    20.9676  -13.3516
            11  C1x C    19.7092  -12.6525
            12  C1x C    18.5206  -13.3516
            13  C1x C    18.5206  -14.7499
            14  C1b C    18.5906  -17.5465
            15  C1b C    17.4021  -16.9173
            16  N1y N    16.1436  -17.6164
            17  C1x C    14.9550  -16.9173
            18  C1x C    13.7665  -17.6164
            19  C1x C    13.7665  -19.0147
            20  C1x C    14.9550  -19.6439
            21  C1x C    16.1436  -18.9448
            22  O1a O    21.0376  -16.1482
BOND        24
            1     1   2 2
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 2
            6     1   6 1
            7     7   8 1
            8     8   9 1
            9     5   9 1
            10    7  10 1
            11   10  11 1
            12   11  12 1
            13   12  13 1
            14    8  13 1
            15    9  14 1
            16   14  15 1
            17   15  16 1
            18   16  17 1
            19   17  18 1
            20   18  19 1
            21   19  20 1
            22   20  21 1
            23   16  21 1
            24    9  22 1

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