| Entry |
|
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| Name |
Dexlansoprazole (INN/USAN);
Dexilant (TN) |
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| Product |
|
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| Generic |
DEXLANSOPRAZOLE (A-S Medication Solutions), DEXLANSOPRAZOLE (A-S Medication Solutions), DEXLANSOPRAZOLE (A-S Medication Solutions), DEXLANSOPRAZOLE (Alembic Pharmaceuticals Limited), DEXLANSOPRAZOLE (Alembic Pharmaceuticals), DEXLANSOPRAZOLE (Bryant Ranch Prepack), DEXLANSOPRAZOLE (Bryant Ranch Prepack), DEXLANSOPRAZOLE (Bryant Ranch Prepack), DEXLANSOPRAZOLE (ENDO USA), DEXLANSOPRAZOLE (Golden State Medical Supply), DEXLANSOPRAZOLE (REMEDYREPACK), DEXLANSOPRAZOLE (TWI PHARMACEUTICALS), DEXLANSOPRAZOLE (Upsher-Smith Laboratories) |
|---|
| Formula |
C16H14F3N3O2S
|
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| Exact mass |
369.0759
|
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| Mol weight |
369.36
|
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| Structure |
|
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| Simcomp |
|
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| Class |
Gastrointestinal agent
DG01975 Agents for peptic ulcer
DG01646 Proton pump inhibitor (PPI)
Metabolizing enzyme substrate
DG01639 CYP2C19 substrate
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
Metabolizing enzyme inhibitor
DG01933 CYP2C19 inhibitor
|
|---|
| Remark |
| Product (DG03298): | D08903<US> D12816<US> |
|
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| Efficacy |
Anti-ulcerative, Proton pump inhibitor |
|---|
| Disease |
Gastroesophageal reflux disease [DS: H01602] |
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| Comment |
Benzimidazole derivative
|
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| Target |
|
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| Pathway |
|
|---|
| Metabolism |
Enzyme: CYP2C19 [HSA: 1557], CYP3A4 [HSA: 1576]
|
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| Interaction |
CYP inhibition: CYP2C19 [HSA: 1557]
|
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| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
A ALIMENTARY TRACT AND METABOLISM
A02 DRUGS FOR ACID RELATED DISORDERS
A02B DRUGS FOR PEPTIC ULCER AND GASTRO-OESOPHAGEAL REFLUX DISEASE (GORD)
A02BC Proton pump inhibitors
A02BC06 Dexlansoprazole
D08903 Dexlansoprazole (INN/USAN) <US>
USP drug classification [BR:br08302]
Gastrointestinal Agents
Proton Pump Inhibitors
Dexlansoprazole
D08903 Dexlansoprazole (INN/USAN)
Drug groups [BR:br08330]
Gastrointestinal agent
DG01975 Agents for peptic ulcer
DG01646 Proton pump inhibitor (PPI)
DG03298 Dexlansoprazole
D08903 Dexlansoprazole
Metabolizing enzyme substrate
DG01639 CYP2C19 substrate
DG03298 Dexlansoprazole
D08903 Dexlansoprazole
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
DG03298 Dexlansoprazole
D08903 Dexlansoprazole
Metabolizing enzyme inhibitor
DG01933 CYP2C19 inhibitor
DG03298 Dexlansoprazole
D08903 Dexlansoprazole
Drug classes [BR:br08332]
Gastrointestinal agent
DG01646 Proton pump inhibitor (PPI)
D08903 Dexlansoprazole
Target-based classification of drugs [BR:br08310]
Enzymes
Hydrolases (EC3)
ATPase
ATP4
D08903 Dexlansoprazole (INN/USAN) <US>
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
D08903
Pharmacogenomic biomarkers [br08341.html]
Polymorphisms and mutations affecting drug response
D08903
Drug groups [BR:br08330]
Gastrointestinal agent
DG01975 Agents for peptic ulcer
DG01646 Proton pump inhibitor (PPI)
DG03298 Dexlansoprazole
Metabolizing enzyme substrate
DG01639 CYP2C19 substrate
DG03298 Dexlansoprazole
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
DG03298 Dexlansoprazole
Metabolizing enzyme inhibitor
DG01933 CYP2C19 inhibitor
DG03298 Dexlansoprazole
|
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| Other DBs |
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| LinkDB |
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| KCF data |
ATOM 25
1 C8x C 8.1200 -19.9500
2 C8x C 8.1200 -21.3500
3 C8x C 9.3324 -22.0500
4 C8y C 10.5449 -21.3500
5 C8y C 10.5449 -19.9500
6 C8x C 9.3324 -19.2500
7 N5x N 11.8764 -21.7826
8 C8y C 12.6993 -20.6500
9 N4x N 11.8764 -19.5174
10 S4a S 14.0700 -20.6500
11 C1b C 14.7700 -21.8624
12 O3c O 14.7700 -19.4376
13 C8y C 16.1698 -21.8624
14 C8y C 16.8603 -23.0580
15 C8y C 18.2603 -23.0578
16 C8x C 18.9601 -21.8453
17 C8x C 18.2697 -20.6498
18 N5x N 16.8697 -20.6499
19 C1a C 16.1749 -24.2452
20 O2a O 18.9510 -24.2532
21 C1b C 20.3696 -24.2532
22 C1d C 21.0556 -25.4406
23 X F 21.7556 -26.6531
24 X F 22.2680 -24.7406
25 X F 19.8432 -26.1406
BOND 27
1 1 2 2
2 2 3 1
3 3 4 2
4 4 5 1
5 5 6 2
6 1 6 1
7 4 7 1
8 7 8 2
9 8 9 1
10 5 9 1
11 8 10 1
12 10 11 1 #Down
13 10 12 2
14 11 13 1
15 13 14 2
16 14 15 1
17 15 16 2
18 16 17 1
19 17 18 2
20 13 18 1
21 14 19 1
22 15 20 1
23 20 21 1
24 21 22 1
25 22 23 1
26 22 24 1
27 22 25 1
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