KEGG   DRUG: Omacetaxine mepesuccinate
Entry
D08956                      Drug                                   
Name
Omacetaxine mepesuccinate (USAN);
Homoharringtonine;
Synribo (TN)
Formula
C29H39NO9
Exact mass
545.2625
Mol weight
545.62
Structure
Simcomp
Source
Cephalotaxus [TAX:50178]
Remark
ATC code: L01XX40
Efficacy
Antineoplastic, Protein biosynthesis inhibitor
  Disease
Chronic myeloid leukemia [DS:H00004]
Target
CCND1 [HSA:595] [KO:K04503]
MCL1 [HSA:4170] [KO:K02539]
MYC [HSA:4609] [KO:K04377]
  Pathway
hsa04010  MAPK signaling pathway
hsa04151  PI3K-Akt signaling pathway
hsa05200  Pathways in cancer
hsa05220  Chronic myeloid leukemia
  Network
nt06276  Chronic myeloid leukemia
Interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 L ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
  L01 ANTINEOPLASTIC AGENTS
   L01X OTHER ANTINEOPLASTIC AGENTS
    L01XX Other antineoplastic agents
     L01XX40 Omacetaxine mepesuccinate
      D08956  Omacetaxine mepesuccinate (USAN)
USP drug classification [BR:br08302]
 Antineoplastics
  Antineoplastics, Other
   Antineoplastics, Miscellaneous
    Omacetaxine Mepesuccinate
     D08956  Omacetaxine mepesuccinate (USAN)
Target-based classification of drugs [BR:br08310]
 Not elsewhere classified
  Genetic information processing
   Transcription factor
    MYC
     D08956  Omacetaxine mepesuccinate (USAN)
  Cellular process
   Cell cycle
    CCND1
     D08956  Omacetaxine mepesuccinate (USAN)
   Apoptosis
    MCL1
     D08956  Omacetaxine mepesuccinate (USAN)
New drug approvals in the USA [br08319.html]
 New molecular entities and new therapeutic biological products
  D08956
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D08956
Pharmacogenomic biomarkers [br08341.html]
 Somatic variations in targeted cancer therapies
  D08956
Other DBs
CAS: 26833-87-4
PubChem: 96025639
ChEBI: 71019
PDB-CCD: HMT[PDBj]
LigandBox: D08956
NIKKAJI: J123.154E
LinkDB
KCF data

ATOM        39
            1   C8x C    17.6397  -10.6348
            2   C8y C    18.8674  -11.3579
            3   C8y C    16.4129  -11.3276
            4   C8y C    18.8680  -12.7739
            5   C1x C    19.9053  -10.4449
            6   C8y C    16.4136  -12.7437
            7   C1y C    20.0013  -13.6231
            8   C8x C    17.6411  -13.4668
            9   C1x C    21.3216  -10.7589
            10  C1z C    21.3227  -13.2764
            11  C1y C    19.8446  -15.0392
            12  N1y N    21.9515  -12.0173
            13  C2x C    22.0156  -14.5033
            14  C2y C    21.1350  -15.5735
            15  O2a O    21.4189  -16.9266
            16  O2x O    15.0659  -10.8908
            17  C1x C    14.2341  -12.0366
            18  O2x O    15.0672  -13.1819
            19  C1x C    23.5746  -13.6143
            20  C1x C    23.3434  -12.2263
            21  C1x C    22.4975  -14.0511
            22  C1a C    22.7562  -17.3649
            23  O7a O    18.6093  -16.1899
            24  C7a C    18.6093  -17.5899
            25  C1d C    17.4135  -18.2801
            26  O6a O    19.8209  -18.2896
            27  C1b C    16.2093  -17.5846
            28  C7a C    15.0261  -18.2674
            29  O7a O    13.8329  -17.5781
            30  O6a O    15.0258  -19.6698
            31  C1a C    12.6442  -18.2642
            32  C1b C    17.4135  -19.6801
            33  C1b C    16.2178  -20.3704
            34  C1b C    16.2178  -21.7704
            35  C1d C    15.0223  -22.4608
            36  O1a O    13.8099  -23.1608
            37  C1a C    15.7329  -23.6921
            38  C1a C    14.3335  -21.2673
            39  O1a O    18.4034  -19.2700
BOND        43
            1     1   2 1
            2     1   3 2
            3     2   4 2
            4     2   5 1
            5     3   6 1
            6     4   7 1
            7     4   8 1
            8     5   9 1
            9     7  10 1
            10    7  11 1
            11    9  12 1
            12   10  13 1
            13   11  14 1
            14   14  15 1
            15    6   8 2
            16   10  12 1
            17   13  14 2
            18    3  16 1
            19   16  17 1
            20   17  18 1
            21    6  18 1
            22   19  20 1
            23   12  20 1
            24   10  21 1 #Down
            25   21  19 1
            26   15  22 1
            27   11  23 1 #Up
            28   23  24 1
            29   24  25 1
            30   24  26 2
            31   25  27 1
            32   27  28 1
            33   28  29 1
            34   28  30 2
            35   29  31 1
            36   25  32 1
            37   32  33 1
            38   33  34 1
            39   34  35 1
            40   35  36 1
            41   35  37 1
            42   35  38 1
            43   25  39 1 #Down

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