KEGG ORTHOLOGY: K02539

ORTHOLOGY: K02539

Entry

K02539                      KO

Symbol

MCL1

Name

myeloid leukemia cell differntiation protein MCL-1

Pathway

map04151

PI3K-Akt signaling pathway

map04210

Apoptosis

map04630

JAK-STAT signaling pathway

map05206

MicroRNAs in cancer

Brite

KEGG Orthology (KO) [BR:ko00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04630 JAK-STAT signaling pathway
    K02539  MCL1; myeloid leukemia cell differntiation protein MCL-1
   04151 PI3K-Akt signaling pathway
    K02539  MCL1; myeloid leukemia cell differntiation protein MCL-1
09140 Cellular Processes
  09143 Cell growth and death
   04210 Apoptosis
    K02539  MCL1; myeloid leukemia cell differntiation protein MCL-1
09160 Human Diseases
  09161 Cancer: overview
   05206 MicroRNAs in cancer
    K02539  MCL1; myeloid leukemia cell differntiation protein MCL-1

Genes

HSA:	4170(MCL1)

PTR:	457274(MCL1)

PPS:	100979595(MCL1)

GGO:	101137633(MCL1)

PON:	100436188(MCL1)

PPYG:

129029748(MCL1)

NLE:	100604947(MCL1)

HMH:	116469481(MCL1)

SSYN:

134734262(MCL1)

MCC:	707539(MCL1)

MCF:	101925224(MCL1)

MTHB:

126932242

MNI:	105497810(MCL1)

CSAB:

103247197(MCL1)

CATY:

105590194(MCL1)

PANU:

101018141(MCL1)

TGE:	112613772(MCL1)

MLEU:

105534759(MCL1)

RRO:	104681074(MCL1)

RBB:	108533266(MCL1)

TFN:	117075676(MCL1)

PTEH:

111543617(MCL1)

CANG:

105508841(MCL1)

CJC:	100406790(MCL1)

SBQ:	101046604(MCL1)

CIMI:

108316470(MCL1)

ANAN:

105724210(MCL1)

CSYR:

103252798

MMUR:

105863822 105872991(MCL1)

LCAT:

123628160 123633922(MCL1)

PCOQ:

105821931(MCL1) 105822480

OGA:	100952786(MCL1)

MMU:	17210(Mcl1)

MCAL:

110291321(Mcl1)

MPAH:

110320476(Mcl1)

RNO:	60430(Mcl1)

MCOC:

116093420(Mcl1)

ANU:	117706908(Mcl1)

ASYL:

127682981(Mcl1)

MUN:	110556651(Mcl1)

CGE:	100764237(Mcl1) 113836994

MAUA:

101842733(Mcl1)

PROB:

127233051(Mcl1)

PLEU:

114682383(Mcl1)

MORG:

121437928 121450726

MFOT:

126489969

AAMP:

119800874(Mcl1)

NGI:	103729108(Mcl1)

HGL:	101724340(Mcl1)

CPOC:

100721658(Mcl1)

CCAN:

109681197(Mcl1)

DORD:

105984886(Mcl1)

DSP:	122109719(Mcl1)

DMER:

138821452 138827480

PLOP:

125359248(Mcl1)

NCAR:

124973083 124973085 124983474

ITI:	101974952(Mcl1)

OCU:

100359222

OPI:	101531517(MCL1)

TUP:	102472561(MCL1)

GVR:	103600355(MCL1) 103610609

CFA:	403537(MCL1)

CLUD:

112664006(MCL1)

VVP:	112907657(MCL1)

VLG:	121490958(MCL1)

NPO:	129501386(MCL1) 129512679

AML:	100484433(MCL1)

UMR:	103667602(MCL1)

UAH:	113246198(MCL1)

UAR:	123787744(MCL1)

ELK:	111161960 111161961

LLV:

125097752

MPUF:

101685396(MCL1)

MNP:	132001445(MCL1)

MLK:	131809984(MCL1)

NVS:	122900437(MCL1)

ORO:	101368348(MCL1) 101376217

EJU:	114197263(MCL1)

ZCA:	113931774(MCL1) 113932555 118356016

MLX:	118000307(MCL1)

NSU:	110577896 110578602(MCL1)

LWW:	102728269(MCL1)

FCA:	493970(MCL1)

PYU:	121021049(MCL1)

PCOO:

112848641(MCL1)

PBG:	122481125(MCL1)

PVIV:

125159502(MCL1)

LRUF:

124515533

LGF:	123598656(MCL1)

AJU:

106986653

PTG:	102965985(MCL1)

PPAD:

109256986(MCL1)

PUC:

125912129

PLEZ:

122228673(MCL1)

HHV:	120241269(MCL1)

BTA:	788087(MCL1)

BOM:	102283384(MCL1)

BIU:	109555382(MCL1) 109564155

BBUB:

102403565(MCL1)

BBIS:

104987708(MCL1)

CHX:	102185798(MCL1)

OAS:	554329(MCL1)

BTAX:

128045164(MCL1)

CSUM:

138072882(MCL1)

ODA:	120855923(MCL1)

CCAD:

122434328(MCL1)

MREE:

136146039(MCL1)

OVR:	110149572(MCL1)

MBEZ:

129541406(MCL1)

SSC:	397648(MCL1)

CFR:	102509345(MCL1)

CBAI:

105071745(MCL1)

CDK:	105103187(MCL1)

VPC:	102543191(MCL1)

BACU:

103006100(MCL1)

BMUS:

118885564(MCL1)

LVE:	103090946(MCL1)

OOR:	101289701(MCL1)

LALB:

132514394(MCL1) 132528895

GMF:	115846970(MCL1)

DDP:	132436492(MCL1)

DLE:	111169732(MCL1)

PCAD:

102993677 112061831(MCL1)

PSIU:

116760285(MCL1)

PPHC:

136128487(MCL1)

NASI:

112413739(MCL1)

ECB:	100054765(MCL1)

EPZ:	103547666(MCL1)

EAI:	106846539(MCL1)

MYB:	102262272(MCL1)

MMYO:

118673323(MCL1)

MLF:	102441536(MCL1)

MDT:	132220904(MCL1)

MYUM:

138995545(MCL1)

PKL:	118727472(MCL1)

EFUS:

103298971(MCL1)

MNA:	107539147(MCL1)

DRO:	112313500(MCL1)

AJM:	119034639(MCL1)

PDIC:

114488771(MCL1)

PHAS:

123804387(MCL1)

MMF:	118637247(MCL1)

PPAM:

129072028(MCL1)

HAI:	109372291(MCL1)

RFQ:	117014629(MCL1)

PALE:

102884014(MCL1)

PGIG:

120585206(MCL1)

PVP:	105303816(MCL1)

RAY:	107499014(MCL1)

MJV:	108403236(MCL1)

TOD:	119236308(MCL1) 119243747

SARA:

101552314(MCL1)

SFUM:

130019749(MCL1)

SETR:

125997350 125997564(MCL1) 126022169

LAV:	100676317(MCL1)

TMU:

101350934

ETF:	101654686(MCL1)

DNM:	101446090(MCL1)

MDO:	100017262(MCL1)

GAS:	123244267(MCL1)

SHR:	100928648(MCL1)

AFZ:

127559106

PCW:	110220506(MCL1)

TVP:	118856597(MCL1)

PBRV:

138162702(MCL1)

OAA:	114807992(MCL1)

TACU:

119947316(MCL1)

GGA:	395674(MCL1)

PCOC:

116240841(MCL1)

MGP:	100540044(MCL1)

CJO:	107324527(MCL1)

TPAI:

128092059(MCL1)

LMUT:

125685845(MCL1)

NMEL:

110387955(MCL1)

APLA:

101803270(MCL1)

ACYG:

106029353(MCL1)

CATA:

118260691(MCL1)

AFUL:

116499778(MCL1)

TGU:	115498460(MCL1)

LSR:	110471539(MCL1)

PMOA:

120498957(MCL1)

OTC:

121336425

PRUF:

121355886

ATRC:

139605417(MCL1)

OMA:	130263440(MCL1)

PHI:	102111555(MCL1)

PMAJ:

107198998(MCL1)

ACOE:

138098546(MCL1)

ZLE:	135457853(MCL1)

SVG:	106861137(MCL1)

MMEA:

130586927

HRT:	120764351(MCL1)

SATI:

136372994

CCIC:

134055296(MCL1)

FCH:	102058939(MCL1)

SHAB:

115602795(MCL1)

TALA:

104367753(MCL1)

ACHC:

115345514(MCL1)

HLE:	104834110(MCL1)

AGEN:

126040681

HHAR:

128145719(MCL1)

GCL:

127027042

PPUS:

135192760(MCL1)

AVIT:

104280236

NNI:	104020494(MCL1)

PADL:

103913345(MCL1)

CBOY:

140644169(MCL1)

CLV:	102097620(MCL1)

CNIC:

136000125(MCL1)

RTD:	128900931(MCL1)

CRID:

134525803(MCL1)

AROW:

112972529(MCL1)

NPD:	112952961(MCL1)

TGT:	104573265(MCL1)

SCAM:

104149061(MCL1)

AMJ:	102565309(MCL1)

CMY:	102947037(MCL1)

CCAY:

125625565(MCL1)

DCC:	119847902(MCL1)

CPIC:

101937549(MCL1)

TST:	117869545(MCL1)

CABI:

116830579(MCL1)

MRV:	120389975(MCL1)

ACS:	100556744(mcl1)

ASAO:

132764187(MCL1)

PVT:	110081542(MCL1)

SUND:

121915732(MCL1)

PBI:	103056794(MCL1)

PMUR:

107292903(MCL1)

CTIG:

120317000(MCL1)

TSR:	106540600(MCL1)

PGUT:

117670142(MCL1)

PCAE:

139322048(MCL1)

APRI:

131186678(MCL1)

PTEX:

113453020 113453024

NSS:	113425705(MCL1)

VKO:	123032891(MCL1)

PMUA:

114586110(MCL1)

PRAF:

128403597(MCL1)

ZVI:	118075606(MCL1)

HCG:	128337507(MCL1)

STOW:

125440939(MCL1)

EMC:	129342248(MCL1)

XLA:	100192362(mcl1.L) 108700339(mcl1.S)

XTR:	100038211(mcl1)

NPR:	108789796(MCL1)

RTEM:

120920920(MCL1)

ACAT:

141117183(MCL1)

BBUF:

120982515(MCL1)

BGAR:

122921556(MCL1)

DTC:	141083055(MCL1)

PWL:	138268669(MCL1)

MUO:	115457739(MCL1)

GSH:	117350297(MCL1)

DRE:	58122(mcl1a)

SRX:	107714756 107732475 107741748 107744212

SANH:

107663357 107689846 107691317 107701890

SGH:	107571620 107580299 107587828 107597989

CCAR:

109048962 109070211 109105991

CAUA:

113059157 113062487 113077609 113116103 113119709 113119765

CGIB:

127935123 127978627

PTET:

122335196(mcl1a)

LROH:

127181963(mcl1a)

GRF:	141290347(mcl1a)

OMC:	131525203(mcl1a)

PPRM:

120475237(mcl1a)

RKG:	130092406(mcl1a)

MAMB:

125275998(mcl1a)

CIDE:

127501495

CERY:

137037414(mcl1a)

MASI:

127421235 127425118

TROS:

130566902(mcl1a)

TDW:	130415986(mcl1a)

MANU:

129455532(mcl1a)

PDAB:

135773962(mcl1a)

IPU:	108268142(mcl1b) 108274846

IFU:	128610398(mcl1b) 128618528

PHYP:

113525384 113533995

SMEO:

124392181

TFD:	113644743(mcl1b) 113647445(mcl1a)

TVC:	132845885(mcl1b) 132857121

CGAR:

128520076(mcl1b) 128543013

NGRA:

132864542 132866566 132867722 132867732 132875463 132875470 132886824(mcl1b)

TRN:	134310796(mcl1b) 134317397

AMEX:

103046057(mcl1b) 111197410(mcl1a)

CMAO:

118812804 118812809 118817515(mcl1b)

EEE:	113575249 113590163

CHAR:

105891947(mcl1b) 105902025

SPIL:

134072685(mcl1a)

TRU:

101069436

TFS:	130532157(mcl1b)

TNG:	GSTEN00011680G001

LCO:

104923932

NCC:

104944908

TBEN:

117494825(mcl1b)

CGOB:

115020805

PGEO:

117461214(mcl1b)

GACU:

117535708

EMAC:

134862039(mcl1b)

ELY:	117266073(mcl1b)

EFO:	125892611(mcl1b)

PLEP:

121945754(mcl1b)

SLUC:

116049095(mcl1b)

ECRA:

117946466(mcl1b)

ESP:	116677137 116690909

PFLV:

114557134

GAT:	120810487(mcl1b)

PPUG:

119197850(mcl1b) 119205177 119205306 134107510 134109784 134132849

AFB:	129109074(mcl1b)

CLUM:

117745893(mcl1b)

PSWI:

130191191 130196114 130212982(mcl1b)

CANA:

137781652(mcl1b)

CVE:	137888131(mcl1b)

MSAM:

119897019(mcl1b)

SCHU:

122882287(mcl1b)

CUD:	121513449(mcl1b)

SPUL:

138584350(mcl1b)

LMIX:

132983464(mcl1b)

ALAT:

119006466(mcl1b) 119015886 119016366

ASTR:

137600889(mcl1b)

MZE:

101488044

ONL:	100695229 100696306 109202993 112845086

OAU:	116318001 116333450(mcl1b) 120436764

OLA:

101165916

OML:	112136551(mcl1b)

CSAI:

133440204(mcl1b)

XMA:

XCO:

XHE:

PRET:

PFOR:

PLAI:

PMEI:

GAF:	122830847(mcl1b)

PPRL:

129370977(mcl1b)

CVG:

107084596

CTUL:

119781851(mcl1b)

GMU:	124865543(mcl1b)

NFU:

107379220

KMR:	108243239(mcl1b)

ALIM:

106524069

NWH:	119409849(mcl1b)

AOCE:

111571635(mcl1b) 111572843

EJA:	138213719(mcl1b)

BFRE:

138628728(mcl1b)

MCEP:

125016415(mcl1b)

CSEM:

103376855 103388701

POV:

109633486

SSEN:

122774499(mcl1b) 122780846

SSOE:

131468711 131471228(mcl1b)

HHIP:

117776971(mcl1b)

HSP:	118113980(mcl1b)

PPLT:

128449195(mcl1b)

SMAU:

118285567(mcl1b)

LCF:	108883179(mcl1b)

SDU:

111222415

SLAL:

111669226

XGL:	120784286(mcl1b)

HCQ:	109512183 109520706 109526726

SSCV:

125971008 125974689(mcl1b)

SBIA:

133501525(mcl1b) 133501662 133502189 133502221 133502251 133502317 133502439 133502504 133502597 133502598

PEE:	133401552(mcl1b) 133402482

PTAO:

133478643 133480125(mcl1b)

BPEC:

110162674

ENY:	140354251 140365741 140374338(mcl1b)

MALB:

109968964

BSPL:

114842651(mcl1b)

SJO:	128365730(mcl1b)

SSCO:

133984100(mcl1b)

GMH:

115554641

SASA:

100136422(mcl-1) 106580904 106584481 106593707 106595026 106597546 106598417 106598835 106598883 106600250

STRU:

115176776 115178942

OTW:	112222943 112229253 121841549

OMY:	110487180 110514588 118948746 118952221 118954888

OGO:	123997755 124005629

ONE:	115103930 115141057

OKI:	109902018 109908523 116372548

OKE:	118364452 118367496 118379572 127923370

OMM:	135520257 135522237 135529989 135539051

OCLA:

139364973 139392375 139409702 139417530

SALP:

111959066 111965098

SNH:	120022305 120022316 120030771 120048419(mcl1b)

CCLU:

121543129 121555277 121574674 123482109 123483282

ELS:	105031245 114832425 114832832 114835960 114837857

OEP:	134023399(mcl1b)

SFM:	108930426 108941856

PKI:	111838380 111860667

AANG:

118231913(mcl1b) 118233315

AROT:

135260207 135263539(mcl1b)

CCOG:

133105522 133136642

LOC:

102685895

PSPA:

121309880(mcl1b)

ARUT:

117395593

LCM:	102350724(MCL1)

RTP:

HOC:

HAKA:

PMRN:

LRJ:

SPU:

SKO:

PFLL:

LGI:	LOTGIDRAFT_234736

PCAN:

GAE:

OBI:

LAK:

HMG:	100215682(bcl-2)

» show all

Reference

PMID:10766760

Authors

Bingle CD, Craig RW, Swales BM, Singleton V, Zhou P, Whyte MK

Title

Exon skipping in Mcl-1 results in a bcl-2 homology domain 3 only gene product that promotes cell death.

Journal

J Biol Chem 275:22136-46 (2000)
DOI:10.1074/jbc.M909572199

Reference

PMID:10978339

Authors

Fujise K, Zhang D, Liu J, Yeh ET

Title

Regulation of apoptosis and cell cycle progression by MCL1. Differential role of proliferating cell nuclear antigen.

Journal

J Biol Chem 275:39458-65 (2000)
DOI:10.1074/jbc.M006626200

Sequence

[hsa:4170]

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