KEGG   ORTHOLOGY: K02539
Entry
K02539                      KO                                     
Symbol
MCL1
Name
myeloid leukemia cell differntiation protein MCL-1
Pathway
map04151  PI3K-Akt signaling pathway
map04210  Apoptosis
map04630  JAK-STAT signaling pathway
map05206  MicroRNAs in cancer
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04630 JAK-STAT signaling pathway
    K02539  MCL1; myeloid leukemia cell differntiation protein MCL-1
   04151 PI3K-Akt signaling pathway
    K02539  MCL1; myeloid leukemia cell differntiation protein MCL-1
 09140 Cellular Processes
  09143 Cell growth and death
   04210 Apoptosis
    K02539  MCL1; myeloid leukemia cell differntiation protein MCL-1
 09160 Human Diseases
  09161 Cancer: overview
   05206 MicroRNAs in cancer
    K02539  MCL1; myeloid leukemia cell differntiation protein MCL-1
Genes
HSA: 4170(MCL1)
PTR: 457274(MCL1)
PPS: 100979595(MCL1)
GGO: 101137633(MCL1)
PON: 100436188(MCL1)
NLE: 100604947(MCL1)
MCC: 707539(MCL1)
MCF: 101925224(MCL1)
MTHB: 126932242
CSAB: 103247197(MCL1)
CATY: 105590194(MCL1)
PANU: 101018141(MCL1)
TGE: 112613772(MCL1)
RRO: 104681074(MCL1)
RBB: 108533266(MCL1)
TFN: 117075676(MCL1)
PTEH: 111543617(MCL1)
CANG: 105508841(MCL1)
CJC: 100406790(MCL1)
SBQ: 101046604(MCL1)
CSYR: 103252798
MMUR: 105863822 105872991(MCL1)
LCAT: 123628160 123633922(MCL1)
PCOQ: 105821931(MCL1) 105822480
OGA: 100952786(MCL1)
MMU: 17210(Mcl1)
MCAL: 110291321(Mcl1)
MPAH: 110320476(Mcl1)
RNO: 60430(Mcl1)
MCOC: 116093420(Mcl1)
MUN: 110556651(Mcl1)
CGE: 100764237(Mcl1) 113836994
MAUA: 101842733(Mcl1)
PLEU: 114682383(Mcl1)
MFOT: 126489969
AAMP: 119800874(Mcl1)
NGI: 103729108(Mcl1)
HGL: 101724340(Mcl1)
CPOC: 100721658(Mcl1)
CCAN: 109681197(Mcl1)
DORD: 105984886(Mcl1)
DSP: 122109719(Mcl1)
OCU: 100359222
OPI: 101531517(MCL1)
TUP: 102472561(MCL1)
GVR: 103600355(MCL1) 103610609
CFA: 403537(MCL1)
CLUD: 112664006(MCL1)
VVP: 112907657(MCL1)
VLG: 121490958(MCL1)
AML: 100484433(MCL1)
UMR: 103667602(MCL1)
UAH: 113246198(MCL1)
UAR: 123787744(MCL1)
LLV: 125097752
MPUF: 101685396(MCL1)
ORO: 101368348(MCL1) 101376217
EJU: 114197263(MCL1)
MLX: 118000307(MCL1)
NSU: 110577896 110578602(MCL1)
LWW: 102728269(MCL1)
FCA: 493970(MCL1)
PYU: 121021049(MCL1)
PBG: 122481125(MCL1)
LRUF: 124515533
PTG: 102965985(MCL1)
PPAD: 109256986(MCL1)
AJU: 106986653(MCL1)
HHV: 120241269(MCL1)
BTA: 788087(MCL1)
BOM: 102277523 102283384(MCL1)
BIU: 109555382(MCL1) 109564155
BBUB: 102403565(MCL1)
BBIS: 104987708(MCL1)
CHX: 102185798(MCL1)
OAS: 554329(MCL1)
ODA: 120855923(MCL1)
CCAD: 122434328(MCL1)
SSC: 397648(MCL1)
CFR: 102509345(MCL1)
CBAI: 105071745(MCL1)
CDK: 105103187(MCL1)
VPC: 102543191(MCL1)
BACU: 103006100(MCL1)
LVE: 103090946(MCL1)
OOR: 101289701(MCL1)
DLE: 111169732(MCL1)
PCAD: 102993677 112061831(MCL1)
PSIU: 116760285(MCL1)
ECB: 100054765(MCL1)
EPZ: 103547666(MCL1)
EAI: 106846539(MCL1)
MYB: 102262272(MCL1)
MMYO: 118673323(MCL1)
MLF: 102441536(MCL1)
MNA: 107539147(MCL1)
PKL: 118727472(MCL1)
HAI: 109372291(MCL1)
DRO: 112313500(MCL1)
AJM: 119034639(MCL1) 119045222
PDIC: 114488771(MCL1)
PHAS: 123804387(MCL1)
MMF: 118637247(MCL1)
RFQ: 117014629(MCL1)
PALE: 102884014(MCL1)
PGIG: 120585206(MCL1)
PVP: 105303816(MCL1)
RAY: 107499014(MCL1)
MJV: 108403236(MCL1)
TOD: 119236308(MCL1) 119243747
SARA: 101552314(MCL1)
LAV: 100676317(MCL1)
TMU: 101350934
ETF: 101654686(MCL1)
DNM: 101446090(MCL1)
MDO: 100017262(MCL1)
GAS: 123244267(MCL1)
SHR: 100928648(MCL1)
PCW: 110220506(MCL1)
OAA: 114807992(MCL1)
GGA: 395674(MCL1)
PCOC: 116240841(MCL1)
MGP: 100540044(MCL1)
CJO: 107324527(MCL1)
NMEL: 110387955(MCL1)
ACYG: 106029353(MCL1)
AFUL: 116499778(MCL1)
TGU: 115498460(MCL1)
LSR: 110471539(MCL1)
PMOA: 120498957(MCL1)
OTC: 121336425
PRUF: 121355886
PHI: 102111555(MCL1)
PMAJ: 107198998(MCL1)
FCH: 102058939(MCL1)
CLV: 102097620(MCL1)
NNI: 104020494(MCL1)
TALA: 104367753(MCL1)
PADL: 103913345(MCL1)
ACHC: 115345514(MCL1)
HLE: 104834110(MCL1)
AGEN: 126040681
GCL: 127027042
AVIT: 104280236
CUCA: 104057095(MCL1)
AROW: 112972529(MCL1)
NPD: 112952961(MCL1)
TGT: 104573265(MCL1)
SCAM: 104149061(MCL1)
AMJ: 102565309(MCL1)
CMY: 102947037(MCL1)
CPIC: 101937549(MCL1)
TST: 117869545(MCL1)
CABI: 116830579(MCL1)
MRV: 120389975(MCL1)
ACS: 100556744(mcl1)
PVT: 110081542(MCL1)
SUND: 121915732(MCL1)
PBI: 103056794(MCL1)
PMUR: 107292903(MCL1)
CTIG: 120317000(MCL1)
TSR: 106540600(MCL1)
PGUT: 117670142(MCL1)
VKO: 123032891(MCL1)
PMUA: 114586110(MCL1)
ZVI: 118075606(MCL1)
STOW: 125440939(MCL1)
XLA: 100192362(mcl1.L) 108700339(mcl1.S)
XTR: 100038211(mcl1)
NPR: 108789796(MCL1)
RTEM: 120920920(MCL1)
BBUF: 120982515(MCL1)
BGAR: 122921556(MCL1)
DRE: 58122(mcl1a)
PPRM: 120475237(mcl1a)
MAMB: 125275998(mcl1a)
IPU: 108268142(mcl1b) 108274846
SMEO: 124392181
TFD: 113644743(mcl1b) 113647445(mcl1a)
TRU: 101069436
LCO: 104923932
NCC: 104944908
CGOB: 115020805
ELY: 117266073(mcl1b)
EFO: 125892611(mcl1b)
PLEP: 121945754(mcl1b)
SLUC: 116049095(mcl1b)
ECRA: 117946466(mcl1b)
PFLV: 114557134
GAT: 120810487(mcl1b)
MSAM: 119897019(mcl1b)
CUD: 121513449(mcl1b)
MZE: 101488044
OLA: 101165916
OML: 112136551(mcl1b)
XMA: 102230859
XCO: 114141541
XHE: 116717014
PRET: 103477645
PFOR: 103129193
PLAI: 106949132
PMEI: 106920368
GAF: 122830847(mcl1b)
CVG: 107084596
CTUL: 119781851(mcl1b)
GMU: 124865543(mcl1b)
NFU: 107379220
KMR: 108243239(mcl1b)
ALIM: 106524069
NWH: 119409849(mcl1b)
MCEP: 125016415(mcl1b)
POV: 109633486
SSEN: 122774499(mcl1b) 122780846
HHIP: 117776971(mcl1b)
HSP: 118113980(mcl1b)
LCF: 108883179(mcl1b)
SDU: 111222415
SLAL: 111669226
XGL: 120784286(mcl1b)
BPEC: 110162674
MALB: 109968964
BSPL: 114842651(mcl1b)
AANG: 118231913(mcl1b) 118233315
LOC: 102685895
PSPA: 121309880(mcl1b)
ARUT: 117395593
LCM: 102350724(MCL1)
RTP: 109924282
SPU: 582436
SKO: 100377406
PCAN: 112553808
GAE: 121383127
OBI: 106869231
LAK: 106168952
HMG: 100215682(bcl-2)
 » show all
Reference
  Authors
Bingle CD, Craig RW, Swales BM, Singleton V, Zhou P, Whyte MK
  Title
Exon skipping in Mcl-1 results in a bcl-2 homology domain 3 only gene product that promotes cell death.
  Journal
J Biol Chem 275:22136-46 (2000)
DOI:10.1074/jbc.M909572199
Reference
  Authors
Fujise K, Zhang D, Liu J, Yeh ET
  Title
Regulation of apoptosis and cell cycle progression by MCL1. Differential role of proliferating cell nuclear antigen.
  Journal
J Biol Chem 275:39458-65 (2000)
DOI:10.1074/jbc.M006626200
  Sequence
[hsa:4170]
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