KEGG   ORTHOLOGY: K04377
Entry
K04377                      KO                                     

Symbol
MYC
Name
Myc proto-oncogene protein
Pathway
map04010  MAPK signaling pathway
map04012  ErbB signaling pathway
map04110  Cell cycle
map04151  PI3K-Akt signaling pathway
map04218  Cellular senescence
map04310  Wnt signaling pathway
map04350  TGF-beta signaling pathway
map04390  Hippo signaling pathway
map04391  Hippo signaling pathway - fly
map04550  Signaling pathways regulating pluripotency of stem cells
map04630  JAK-STAT signaling pathway
map04919  Thyroid hormone signaling pathway
map05132  Salmonella infection
map05160  Hepatitis C
map05161  Hepatitis B
map05163  Human cytomegalovirus infection
map05166  Human T-cell leukemia virus 1 infection
map05167  Kaposi sarcoma-associated herpesvirus infection
map05169  Epstein-Barr virus infection
map05200  Pathways in cancer
map05202  Transcriptional misregulation in cancer
map05205  Proteoglycans in cancer
map05206  MicroRNAs in cancer
map05207  Chemical carcinogenesis - receptor activation
map05210  Colorectal cancer
map05213  Endometrial cancer
map05216  Thyroid cancer
map05219  Bladder cancer
map05220  Chronic myeloid leukemia
map05221  Acute myeloid leukemia
map05222  Small cell lung cancer
map05224  Breast cancer
map05225  Hepatocellular carcinoma
map05226  Gastric cancer
map05230  Central carbon metabolism in cancer
Disease
H00001  B-cell acute lymphoblastic leukemia
H00002  T-cell acute lymphoblastic leukemia
H00008  Burkitt lymphoma
H00010  Multiple myeloma
H00013  Small cell lung cancer
H00016  Oral cancer
H00025  Penile cancer
H00027  Ovarian cancer
H00028  Choriocarcinoma
H00036  Osteosarcoma
H00041  Kaposi sarcoma
H00048  Hepatocellular carcinoma
H00055  Laryngeal cancer
H01463  Mycosis fungoides
H01509  Tonsillar cancer
H01554  Fallopian tube cancer
H01667  Medulloblastoma
H02434  Diffuse large B-cell lymphoma, not otherwise specified
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    K04377  MYC; Myc proto-oncogene protein
   04012 ErbB signaling pathway
    K04377  MYC; Myc proto-oncogene protein
   04310 Wnt signaling pathway
    K04377  MYC; Myc proto-oncogene protein
   04350 TGF-beta signaling pathway
    K04377  MYC; Myc proto-oncogene protein
   04390 Hippo signaling pathway
    K04377  MYC; Myc proto-oncogene protein
   04391 Hippo signaling pathway - fly
    K04377  MYC; Myc proto-oncogene protein
   04630 JAK-STAT signaling pathway
    K04377  MYC; Myc proto-oncogene protein
   04151 PI3K-Akt signaling pathway
    K04377  MYC; Myc proto-oncogene protein
 09140 Cellular Processes
  09143 Cell growth and death
   04110 Cell cycle
    K04377  MYC; Myc proto-oncogene protein
   04218 Cellular senescence
    K04377  MYC; Myc proto-oncogene protein
  09144 Cellular community - eukaryotes
   04550 Signaling pathways regulating pluripotency of stem cells
    K04377  MYC; Myc proto-oncogene protein
 09150 Organismal Systems
  09152 Endocrine system
   04919 Thyroid hormone signaling pathway
    K04377  MYC; Myc proto-oncogene protein
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K04377  MYC; Myc proto-oncogene protein
   05202 Transcriptional misregulation in cancer
    K04377  MYC; Myc proto-oncogene protein
   05206 MicroRNAs in cancer
    K04377  MYC; Myc proto-oncogene protein
   05205 Proteoglycans in cancer
    K04377  MYC; Myc proto-oncogene protein
   05207 Chemical carcinogenesis - receptor activation
    K04377  MYC; Myc proto-oncogene protein
   05230 Central carbon metabolism in cancer
    K04377  MYC; Myc proto-oncogene protein
  09162 Cancer: specific types
   05210 Colorectal cancer
    K04377  MYC; Myc proto-oncogene protein
   05225 Hepatocellular carcinoma
    K04377  MYC; Myc proto-oncogene protein
   05226 Gastric cancer
    K04377  MYC; Myc proto-oncogene protein
   05216 Thyroid cancer
    K04377  MYC; Myc proto-oncogene protein
   05221 Acute myeloid leukemia
    K04377  MYC; Myc proto-oncogene protein
   05220 Chronic myeloid leukemia
    K04377  MYC; Myc proto-oncogene protein
   05219 Bladder cancer
    K04377  MYC; Myc proto-oncogene protein
   05213 Endometrial cancer
    K04377  MYC; Myc proto-oncogene protein
   05224 Breast cancer
    K04377  MYC; Myc proto-oncogene protein
   05222 Small cell lung cancer
    K04377  MYC; Myc proto-oncogene protein
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    K04377  MYC; Myc proto-oncogene protein
   05161 Hepatitis B
    K04377  MYC; Myc proto-oncogene protein
   05160 Hepatitis C
    K04377  MYC; Myc proto-oncogene protein
   05163 Human cytomegalovirus infection
    K04377  MYC; Myc proto-oncogene protein
   05167 Kaposi sarcoma-associated herpesvirus infection
    K04377  MYC; Myc proto-oncogene protein
   05169 Epstein-Barr virus infection
    K04377  MYC; Myc proto-oncogene protein
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    K04377  MYC; Myc proto-oncogene protein
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03000 Transcription factors
    K04377  MYC; Myc proto-oncogene protein
   03019 Messenger RNA biogenesis
    K04377  MYC; Myc proto-oncogene protein
Transcription factors [BR:ko03000]
 Eukaryotic type
  Basic helix-loop-helix/leucine zipper (bHLH-ZIP)
   Cell cycle controlling factors, Myc
    K04377  MYC; Myc proto-oncogene protein
Messenger RNA biogenesis [BR:ko03019]
 Eukaryotic type
  mRNA surveillance and transport factors
   Factors involved in mRNA localization
    Factors that have mRNA localization signals
     K04377  MYC; Myc proto-oncogene protein
Genes
HSA: 4609(MYC)
PTR: 464393(MYC)
PPS: 103786410(MYC)
GGO: 101137026(MYC)
PON: 100456735(MYC)
NLE: 100589322(MYC)
MCC: 694626(MYC)
MCF: 102127966(MYC)
CSAB: 103237430(MYC)
CATY: 105588384(MYC)
PANU: 101000645(MYC)
RRO: 104674798(MYC)
RBB: 108528761(MYC)
TFN: 117078846(MYC)
PTEH: 111550563(MYC)
CJC: 100407754(MYC)
SBQ: 101047066(MYC)
MMUR: 105882748(MYC)
MMU: 17869(Myc)
MCAL: 110310583(Myc)
MPAH: 110334656(Myc)
RNO: 24577(Myc)
MCOC: 116082253(Myc)
MUN: 110560064(Myc)
CGE: 100773301(Myc)
PLEU: 114701991(Myc)
NGI: 103743920(Myc)
HGL: 101704740(Myc)
CCAN: 109699943(Myc)
OCU: 100327265(MYC)
TUP: 102501999(MYC)
CFA: 403924(MYC)
VVP: 112915979(MYC)
VLG: 121499098(MYC)
AML: 100464396(MYC)
UMR: 103661697(MYC)
UAH: 113252726(MYC)
ORO: 101369253(MYC)
ELK: 111146783
MPUF: 101689754(MYC)
EJU: 114211166(MYC)
MLX: 118015212(MYC)
FCA: 100379628(MYC)
PYU: 121042977(MYC)
PBG: 122495809(MYC)
PTG: 102954147(MYC)
PPAD: 109273136(MYC)
AJU: 106976895(MYC)
HHV: 120240874(MYC)
BTA: 511077(MYC)
BOM: 102274304(MYC)
BIU: 109568594(MYC)
BBUB: 102402664(MYC)
CHX: 102171262(MYC)
OAS: 443447(MYC)
ODA: 120878883(MYC)
CCAD: 122451212(MYC)
SSC: 448810(MYC)
CFR: 102511086(MYC)
CBAI: 105082940(MYC)
CDK: 105096445(MYC)
BACU: 103016933(MYC)
LVE: 103089962(MYC)
OOR: 101274490(MYC)
DLE: 111164391(MYC)
PCAD: 102988128(MYC)
ECB: 100068097(MYC)
EPZ: 103567860(MYC)
EAI: 106824829(MYC)
MYB: 102257498(MYC)
MYD: 102758544(MYC)
MMYO: 118670599(MYC)
MNA: 107539494(MYC)
HAI: 109383211(MYC)
DRO: 112315592(MYC)
SHON: 118988677(MYC)
AJM: 119064823(MYC)
MMF: 118631560(MYC)
PALE: 102895524(MYC)
PGIG: 120595433(MYC)
RAY: 107506202(MYC)
MJV: 108399996(MYC)
TOD: 119238040(MYC)
LAV: 100665874(MYC)
TMU: 101349786
MDO: 100032344(MYC)
SHR: 100921308(MYC)
PCW: 110216083(MYC)
OAA: 100079391(MYC)
GGA: 420332(MYC)
MGP: 100547931(MYC)
CJO: 107310561(MYC)
NMEL: 110394505(MYC)
APLA: 101803370(MYC)
ACYG: 106038450(MYC)
TGU: 100219849(MYC)
LSR: 110476978(MYC)
SCAN: 103816707(MYC)
PMOA: 120505192(MYC)
FAB: 101819732(MYC)
PHI: 102108851(MYC)
PMAJ: 107200993(MYC)
CCAE: 111925128(MYC)
CCW: 104692644(MYC)
ETL: 114055794(MYC)
FPG: 101923426(MYC)
FCH: 102056832(MYC)
CLV: 102085948(MYC)
EGZ: 104134424(MYC)
NNI: 104016870(MYC)
ACUN: 113476188(MYC)
AAM: 106496220(MYC)
AROW: 112971811(MYC)
NPD: 112959422(MYC)
DNE: 112989193(MYC)
ASN: 102370393(MYC)
AMJ: 102561083(MYC)
GGN: 109299072(MYC)
PSS: 102449445(MYC)
CMY: 102943256(MYC)
CPIC: 101945997(MYC)
TST: 117873814(MYC)
CABI: 116826543(MYC)
ACS: 100558533(myc)
PVT: 110085305(MYC)
PBI: 103057606(MYC)
PMUR: 107299311(MYC)
TSR: 106542510(MYC)
PGUT: 117668415(MYC)
PMUA: 114600250(MYC)
ZVI: 118090392(MYC)
GJA: 107122472(MYC)
XLA: 379052(myc.S) 399315(myc.L)
XTR: 395024(myc)
NPR: 108788968(MYC)
DRE: 30686(myca) 393141(mycb)
IPU: 100304504(myc) 108268289(mycb) 108272607
NCC: 104954577(myc) 104958803
CGOB: 115005048 115025812(myc)
ELY: 117257284(mych) 117264404(myca) 117271564
SLUC: 116045331(myca) 116047779(mych) 116064649
ECRA: 117938040(myca) 117953951
PFLV: 114549120(myc) 114565462
GAT: 120811943(myca) 120834660(mych)
MSAM: 119882023(mych) 119902666 119911475(myca)
CUD: 121506822(mych) 121520189 121527273(myca)
OAU: 116314968 116317109(mych) 116335970(myca)
OLA: 101164933(myc) 101171524(c-myc17)
OML: 112144350 112151214(myca)
CTUL: 119774253 119791708(myca)
KMR: 108230277(myca) 108249494(mych) 108251479
POV: 109629885(myc) 109642921
XGL: 120783284(mych) 120789537(myca) 120800118
BPEC: 110168965 110170064(myc)
SASA: 100380346(myc2) 100380531(myc) 106568625(myc) 106578682 106590162(c-myc)
OMY: 100136645(myc) 110493870(mych) 110527649 110529924(mycb) 110535641(c-myc)
SFM: 108937539(myc) 108942150
LOC: 102684410(myc)
ARUT: 117394278(mycb)
LCM: 102357079(MYC) 102359985
CMK: 103185113(myc)
BFO: 118409317
BBEL: 109463062
APLC: 110980035
SKO: 100303478(myc)
DME: Dmel_CG10798(Myc)
DER: 6550855
DSE: 6616230
DSI: Dsimw501_GD16640(Dsim_GD16640)
DSR: 110184390
DPE: 6597223
DMN: 108161498
DWI: 6648906
DGR: 6565066
DHE: 111598298
CCAT: 101454507
MDE: 101887976
LCQ: 111690376
ACOZ: 120959691
AARA: 120905487
AAG: 5575983
AALB: 109397805
CPII: 120421060
AME: 100576392
ACER: 108002348
BIM: 100749108
BTER: 100650167
CCAL: 108625546
OBB: 114879071
MGEN: 117219484
NMEA: 116425427
CGIG: 122404504
MPHA: 114254415
CFO: 105258327
FEX: 115237099
LHU: 105676895
OBO: 105279511
PCF: 106788614
NVI: 100679741
CSOL: 105359323
MDL: 103572497
CCIN: 107264700
ATD: 109594094
LDC: 111503058
NVL: 108561707
APLN: 108742951
PPYR: 116180555
OTU: 111417350
BMOR: 100862782(myc)
BMAN: 114243276
MSEX: 115447895
BANY: 112046269
PMAC: 106718960
PPOT: 106100280
PXU: 106121250
PRAP: 110995053
HAW: 110373683
TNL: 113497786
PXY: 105385775
BTAB: 109037871
DCI: 103506529
CLEC: 106665891
NLU: 111044294
ZNE: 110831645
CSEC: 111868630
PVM: 113825016
HAME: 121854042
CSCU: 111624731
SDM: 118182885
PCAN: 112574050
BGT: 106051578
CRG: 105337948
MYI: 110459724
LAK: 106173899
ATEN: 116288923
HMG: 100197524(myc1) 100199110(myc2) 105844435
MBR: MONBRDRAFT_33423(MbMyc)
VG: 1491913(Amvgp1) 1491953(ACVgp1)
 » show all
Reference
PMID:6462227
  Authors
Stanton LW, Fahrlander PD, Tesser PM, Marcu KB
  Title
Nucleotide sequence comparison of normal and translocated murine c-myc genes.
  Journal
Nature 310:423-5 (1984)
DOI:10.1038/310423a0
  Sequence
[mmu:17869]
Reference
  Authors
Bellosta P, Hulf T, Balla Diop S, Usseglio F, Pradel J, Aragnol D, Gallant P
  Title
Myc interacts genetically with Tip48/Reptin and Tip49/Pontin to control growth and proliferation during Drosophila development.
  Journal
Proc Natl Acad Sci U S A 102:11799-804 (2005)
DOI:10.1073/pnas.0408945102
  Sequence
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