KEGG   DRUG: Plerixafor
Entry
D08971                      Drug                                   
Name
Plerixafor (JAN/USAN/INN);
Mozobil (TN)
Product
MOZOBIL (sanofi-aventis U.S. LLC)
  Generic
PLERIXAFOR (Amneal Pharmaceuticals LLC), PLERIXAFOR (Dr. Reddy's Laboratories), PLERIXAFOR (Eugia US LLC), PLERIXAFOR (Fresenius Kabi Usa), PLERIXAFOR (Gland Pharma Limited), PLERIXAFOR (Meitheal Pharmaceuticals), PLERIXAFOR (Novadoz Pharmaceuticals LLC), PLERIXAFOR (Sagent Pharmaceuticals), PLERIXAFOR (Teva Pharmaceuticals), PLERIXAFOR (Zydus Lifesciences Limited), PLERIXAFOR (Zydus Pharmaceuticals USA)
Formula
C28H54N8
Exact mass
502.4471
Mol weight
502.78
Structure
Remark
Therapeutic category: 3399
ATC code: L03AX16
Product: D08971<JP/US>
Efficacy
Antineoplastic, Chemokine receptor type 4 (CXCR4) antagonist
  Disease
Non-Hodgkin's lymphoma [DS:H02418]
Multiple myeloma [DS:H00010]
Comment
Hematopoietic stem cell mobilizer
Target
CXCR4 (CD184) [HSA:7852] [KO:K04189]
  Pathway
hsa04060  Cytokine-cytokine receptor interaction
hsa04062  Chemokine signaling pathway
hsa05200  Pathways in cancer
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 L ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
  L03 IMMUNOSTIMULANTS
   L03A IMMUNOSTIMULANTS
    L03AX Other immunostimulants
     L03AX16 Plerixafor
      D08971  Plerixafor (JAN/USAN/INN) <JP/US>
USP drug classification [BR:br08302]
 Blood Products and Modifiers
  Blood Products and Modifiers, Other
   Plerixafor
    D08971  Plerixafor (JAN/USAN/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 3  Agents affecting metabolism
  33  Blood and body fluid agents
   339  Miscellaneous
    3399  Others
     D08971  Plerixafor (JAN/USAN/INN)
Target-based classification of drugs [BR:br08310]
 Cytokines and receptors
  Cytokine receptors
   Chemokine receptors
    CXCR4 (CD184)
     D08971  Plerixafor (JAN/USAN/INN) <JP/US>
New drug approvals in the USA [br08319.html]
 New molecular entities and new therapeutic biological products
  D08971
New drug approvals in Europe [br08329.html]
 European public assessment reports (EPAR) authorised medicine
  D08971
New drug approvals in Japan [br08318.html]
 Drugs with new active ingredients
  D08971
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D08971
Other DBs
CAS: 110078-46-1
PubChem: 96025654
ChEBI: 125354
PDB-CCD: VH6[PDBj]
LigandBox: D08971
LinkDB
KCF data

ATOM        36
            1   C1x C    18.4800   -9.4500
            2   C1x C    18.4800  -10.8500
            3   C1x C    20.9049  -10.8500
            4   C1x C    20.9049   -9.4500
            5   N1x N    19.6924   -8.7500
            6   N1x N    17.2676  -11.5500
            7   C1x C    17.2676  -12.9500
            8   C1x C    18.4800  -13.6500
            9   C1x C    20.9049  -13.6500
            10  N1y N    22.1173  -12.9500
            11  C1x C    22.1173  -11.5500
            12  C1x C    18.4800  -15.0500
            13  N1x N    19.6924  -15.7500
            14  C1x C    20.9049  -15.0500
            15  C1b C    23.3318  -13.6512
            16  C8y C    24.5283  -12.9602
            17  C8x C    25.7151  -13.6454
            18  C8x C    26.9275  -12.9454
            19  C8y C    26.9275  -11.5454
            20  C8x C    25.7407  -10.8602
            21  C8x C    24.5283  -11.5602
            22  C1b C    28.1546  -10.8366
            23  N1y N    29.3618  -11.5334
            24  C1x C    29.3624  -12.9496
            25  C1x C    30.5751  -13.6492
            26  C1x C    30.5740  -10.8330
            27  C1x C    32.9989  -10.8321
            28  C1x C    32.9984   -9.4321
            29  N1x N    31.7857   -8.7326
            30  C1x C    30.5735   -9.4330
            31  C1x C    32.9999  -13.6321
            32  N1x N    34.2121  -12.9317
            33  C1x C    34.2116  -11.5317
            34  C1x C    30.5757  -15.0492
            35  N1x N    31.7884  -15.7487
            36  C1x C    33.0005  -15.0482
BOND        38
            1     1   2 1
            2     3   4 1
            3     4   5 1
            4     1   5 1
            5     2   6 1
            6     6   7 1
            7     7   8 1
            8     9  10 1
            9    10  11 1
            10    3  11 1
            11    8  12 1
            12   12  13 1
            13   13  14 1
            14   14   9 1
            15   10  15 1
            16   15  16 1
            17   16  17 2
            18   17  18 1
            19   18  19 2
            20   19  20 1
            21   20  21 2
            22   16  21 1
            23   19  22 1
            24   22  23 1
            25   23  24 1
            26   24  25 1
            27   23  26 1
            28   27  28 1
            29   28  29 1
            30   29  30 1
            31   26  30 1
            32   31  32 1
            33   32  33 1
            34   27  33 1
            35   25  34 1
            36   34  35 1
            37   35  36 1
            38   36  31 1

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