KEGG   DRUG: Fostamatinib disodiumHelp
Entry
D09348                      Drug                                   

Name
Fostamatinib disodium (USAN);
Fostamatinib disodium hexahydrate;
Tavalisse (TN)
Formula
C23H24FN6O9P. 6H2O. 2Na
Exact mass
732.1756
Mol weight
732.5148
Structure
Mol fileKCF fileDB search
Simcomp SIMCOMP
Class
Antineoplastic
 DG01918  Tyrosine kinase inhibitor
Remark
ATC code: B02BX09
Chemical structure group: DG01419
Product (DG01419): D09347<US>
Efficacy
Antineoplastic, Immunomodulator, Tyrosin kinase inhibitor
  Disease
Immune thrombocytopenia [DS:H01240]
Comment
Treatment of rheumatoid arthritis, immune thrombocytopenic purpura, and B-cell lymphoma
Target
SYK [HSA:6850] [KO:K05855]
  Pathway
hsa04064  NF-kappa B signaling pathway
hsa04611  Platelet activation
hsa04662  B cell receptor signaling pathway
Interaction
Drug interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 B BLOOD AND BLOOD FORMING ORGANS
  B02 ANTIHEMORRHAGICS
   B02B VITAMIN K AND OTHER HEMOSTATICS
    B02BX Other systemic hemostatics
     B02BX09 Fostamatinib
      D09348  Fostamatinib disodium (USAN)
Target-based classification of drugs [BR:br08310]
 Protein kinases
  Non-receptor tyrosine kinases
   SYK family
    SYK
     D09348  Fostamatinib disodium (USAN)
New drug approvals in the USA [br08319.html]
 New molecular entities and new therapeutic biological products
  D09348
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D09348
BRITE hierarchy
Other DBs
CAS: 914295-16-2
PubChem: 96026028
ChEMBL: CHEMBL3989516
LigandBox: D09348
LinkDB All DBs
KCF data Show

ATOM        48
            1   N1b N    18.1871  -24.9940
            2   C8y C    18.1871  -23.5898
            3   N5x N    16.9936  -22.8877
            4   C8x C    16.9936  -21.4836
            5   C8y C    18.1871  -20.7815
            6   C8y C    19.4509  -21.4836
            7   N5x N    19.4509  -22.8877
            8   X   F    18.1871  -19.3773
            9   N1b N    20.6444  -20.7815
            10  C8y C    21.8379  -21.4836
            11  N5x N    23.0315  -20.7815
            12  C8y C    24.2952  -21.4836
            13  C8y C    24.2952  -22.8877
            14  C8x C    23.1017  -23.5898
            15  C8x C    21.8379  -22.8877
            16  N1y N    25.4887  -20.7815
            17  C5x C    26.6823  -21.4836
            18  C1z C    26.6823  -22.8877
            19  O2x O    25.4887  -23.5898
            20  C1a C    27.8758  -23.5898
            21  C1a C    27.8758  -22.1856
            22  O5x O    27.8758  -20.7815
            23  C1b C    25.4887  -19.3773
            24  O2b O    26.6823  -18.6753
            25  P1b P    26.6823  -17.2711
            26  C8y C    19.3807  -25.6960
            27  C8x C    19.3807  -27.1002
            28  C8y C    20.5742  -27.8023
            29  C8y C    21.8379  -27.1002
            30  C8y C    21.8379  -25.6960
            31  C8x C    20.5742  -24.9940
            32  O2a O    23.0315  -27.8023
            33  O2a O    23.0315  -24.9940
            34  O2a O    20.5742  -29.2064
            35  O1c O    28.0864  -17.2711 #-
            36  O1c O    25.2781  -17.2711 #-
            37  O1c O    26.6823  -15.8669
            38  C1a C    24.2250  -25.6960
            39  C1a C    24.2250  -27.1002
            40  C1a C    21.7677  -29.9085
            41  Z   Na   30.2629  -15.7967 #+
            42  Z   Na   30.2629  -18.5348 #+
            43  O0  O    30.3800  -28.8400
            44  O0  O    30.3800  -28.8400
            45  O0  O    30.3800  -28.8400
            46  O0  O    30.3800  -28.8400
            47  O0  O    30.3800  -28.8400
            48  O0  O    30.3800  -28.8400
BOND        43
            1     1   2 1
            2     2   3 2
            3     3   4 1
            4     4   5 2
            5     5   6 1
            6     6   7 2
            7     2   7 1
            8     5   8 1
            9     6   9 1
            10    9  10 1
            11   10  11 2
            12   11  12 1
            13   12  13 2
            14   13  14 1
            15   14  15 2
            16   10  15 1
            17   12  16 1
            18   16  17 1
            19   17  18 1
            20   18  19 1
            21   13  19 1
            22   18  20 1
            23   18  21 1
            24   17  22 2
            25   16  23 1
            26   23  24 1
            27   24  25 1
            28    1  26 1
            29   26  27 2
            30   27  28 1
            31   28  29 2
            32   29  30 1
            33   30  31 2
            34   26  31 1
            35   29  32 1
            36   30  33 1
            37   28  34 1
            38   25  35 1
            39   25  36 1
            40   25  37 2
            41   33  38 1
            42   32  39 1
            43   34  40 1
BRACKET     1    28.4200  -29.7500   28.4200  -27.5800
            1    31.1500  -27.5800   31.1500  -29.7500
            1  6
 ORIGINAL  1   43
 REPEAT    1   44  45  46  47  48

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