KEGG   DRUG: IbalizumabHelp
Entry
D09575                      Drug                                   

Name
Ibalizumab (USAN/INN);
Ibalizumab-uiyk;
Trogarzo (TN)
Product
Sequence
(Heavy chain) QVQLQQSGPE VVKPGASVKM SCKASGYTFT SYVIHWVRQK
PGQGLDWIGY INPYNDGTDY DEKFKGKATL TSDTSTSTAY MELSSLRSED TAVYYCAREK
DNYATGAWFA YWGQGTLVTV SSASTKGPSV FPLAPCSRST SESTAALGCL VKDYFPEPVT
VSWNSGALTS GVHTFPAVLQ SSGLYSLSSV VTVPSSSLGT KTYTCNVDHK PSNTKVDKRV
ESKYGPPCPS CPAPEFLGGP SVFLFPPKPK DTLMISRTPE VTCVVVDVSQ EDPEVQFNWY
VDGVEVHNAK TKPREEQFNS TYRVVSVLTV LHQDWLNGKE YKCKVSNKGL PSSIEKTISK
AKGQPREPQV YTLPPSQEEM TKNQVSLTCL VKGFYPSDIA VEWESNGQPE NNYKTTPPVL
DSDGSFFLYS RLTVDKSRWQ EGNVFSCSVM HEALHNHYTQ KSLSLSLGK (Dimer)
(Light chain) DIVMTQSPDS LAVSLGERVT MNCKSSQSLL YSTNQKNYLA
WYQQKPGQSP KLLIYWASTR ESGVPDRFSG SGSGTDFTLT ISSVQAEDVA VYYCQQYYSY
RTFGGGTKLE IKRTVAAPSV FIFPPSDEQL KSGTASVVCL LNNFYPREAK VQWKVDNALQ
SGNSQESVTE QDSKDSTYSL SSTLTLSKAD YEKHKVYACE VTHQGLSSPV TKSFNRGEC
(Dimer)
  Type
Peptide
Remark
Product: D09575<US>
Efficacy
Antiviral, HIV fusion inhibitor, Anti-CD4 antibody
  Disease
HIV-1 infection [DS:H01563]
Comment
Monoclonal antibody
Treatment of HIV/AIDS in HIV-1 infected patients
Target
CD4 [HSA:920] [KO:K06454]
  Pathway
hsa04514  Cell adhesion molecules (CAMs)
hsa04660  T cell receptor signaling pathway
hsa05170  Human immunodeficiency virus 1 infection
Structure map
map07053  Anti-HIV agents
Brite
Target-based classification of drugs [BR:br08310]
 Cell surface molecules and ligands
  Other cell surface molecules
   CD molecules
    CD4
     D09575  Ibalizumab (USAN/INN) <US>
New drug approvals in the USA [br08319.html]
 New Molecular Entity and New Therapeutic Biological Product Approvals
  D09575
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D09575
BRITE hierarchy
Other DBs
CAS: 680188-33-4
PubChem: 124490315
LinkDB All DBs

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