KEGG ORTHOLOGY: K06454

ORTHOLOGY: K06454

Entry

K06454                      KO

Symbol

CD4

Name

T-cell surface glycoprotein CD4

Pathway

map03250

Viral life cycle - HIV-1

map03260

Virion - Human immunodeficiency virus

map04060

Cytokine-cytokine receptor interaction

map04514

Cell adhesion molecule (CAM) interaction

map04612

Antigen processing and presentation

map04640

Hematopoietic cell lineage

map04658

Th1 and Th2 cell differentiation

map04659

Th17 cell differentiation

map04660

T cell receptor signaling pathway

map05135

Yersinia infection

map05166

Human T-cell leukemia virus 1 infection

map05170

Human immunodeficiency virus 1 infection

map05235

PD-L1 expression and PD-1 checkpoint pathway in cancer

map05340

Primary immunodeficiency

Disease

H02526

Disorders of adaptive immunity

Brite

KEGG Orthology (KO) [BR:ko00001]
09120 Genetic Information Processing
  09125 Information processing in viruses
   03250 Viral life cycle - HIV-1
    K06454  CD4; T-cell surface glycoprotein CD4
   03260 Virion - Human immunodeficiency virus
    K06454  CD4; T-cell surface glycoprotein CD4
09130 Environmental Information Processing
  09133 Signaling molecules and interaction
   04060 Cytokine-cytokine receptor interaction
    K06454  CD4; T-cell surface glycoprotein CD4
   04514 Cell adhesion molecule (CAM) interaction
    K06454  CD4; T-cell surface glycoprotein CD4
09150 Organismal Systems
  09151 Immune system
   04640 Hematopoietic cell lineage
    K06454  CD4; T-cell surface glycoprotein CD4
   04612 Antigen processing and presentation
    K06454  CD4; T-cell surface glycoprotein CD4
   04660 T cell receptor signaling pathway
    K06454  CD4; T-cell surface glycoprotein CD4
   04658 Th1 and Th2 cell differentiation
    K06454  CD4; T-cell surface glycoprotein CD4
   04659 Th17 cell differentiation
    K06454  CD4; T-cell surface glycoprotein CD4
09160 Human Diseases
  09161 Cancer: overview
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    K06454  CD4; T-cell surface glycoprotein CD4
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    K06454  CD4; T-cell surface glycoprotein CD4
   05170 Human immunodeficiency virus 1 infection
    K06454  CD4; T-cell surface glycoprotein CD4
  09171 Infectious disease: bacterial
   05135 Yersinia infection
    K06454  CD4; T-cell surface glycoprotein CD4
  09163 Immune disease
   05340 Primary immunodeficiency
    K06454  CD4; T-cell surface glycoprotein CD4
09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04090 CD molecules
    K06454  CD4; T-cell surface glycoprotein CD4
CD molecules [BR:ko04090]
Proteins
  K06454  CD4; CD4 antigen (p55)

Genes

HSA:

920(CD4)

PTR:	450124(CD4)

PPS:	100970574(CD4)

GGO:	101130322(CD4)

PON:	100452381(CD4)

PPYG:

129010352(CD4)

NLE:	100591806(CD4)

HMH:	116472598(CD4)

SSYN:

129481919(CD4)

MCC:	713807(CD4)

MCF:	101864991(CD4)

MTHB:

126930442

MNI:	105484203(CD4)

CSAB:

103218480(CD4)

CATY:

105583039(CD4)

PANU:

100303658(CD4)

TGE:	112634139(CD4)

MLEU:

105541800(CD4)

RRO:	104680099(CD4)

RBB:	108542050(CD4)

TFN:	117090614(CD4)

PTEH:

111555927(CD4)

CANG:

105518929(CD4)

CJC:	100385000(CD4)

SBQ:	101028824(CD4)

CIMI:

108295007(CD4)

ANAN:

105731187(CD4)

CSYR:

103252157(CD4)

MMUR:

105869095(CD4)

LCAT:

123640106(CD4)

ERUF:

138397552(CD4)

PCOQ:

105805024(CD4)

OGA:	100953378(CD4)

MMU:	12504(Cd4)

MCAL:

110296921(Cd4)

MPAH:

110317139(Cd4)

RNO:	24932(Cd4)

MCOC:

116099586(Cd4)

ANU:	117715411(Cd4)

ASYL:

127679198(Cd4)

MUN:	110548574(Cd4)

CGE:	100766761(Cd4)

MAUA:

101836856(Cd4)

PROB:

127213006(Cd4)

PLEU:

114708820(Cd4)

MORG:

121440366(Cd4)

MFOT:

126514916

AAMP:

119807903(Cd4)

NGI:	103727506(Cd4)

HGL:	101716842(Cd4)

CPOC:

100734494(Cd4)

CCAN:

109682769(Cd4)

DORD:

105991025(Cd4)

DSP:	122101946(Cd4)

DMER:

138815630 138835318

NCAR:

124983047

MMMA:

107154945(Cd4)

ITI:	101971957(Cd4)

OCU:	100009152(CD4)

OPI:	101536290(CD4)

OCZ:	121155459(CD4)

TUP:	102469339(CD4)

GVR:	103586411(CD4)

CFA:	403931(CD4)

CLUD:

112675354(CD4)

VVP:	112917336(CD4)

VLG:	121479658(CD4)

NPO:	129503501(CD4)

AML:	100482689(CD4)

UMR:	103656225(CD4)

UAH:	113257962(CD4)

UAR:	123781683(CD4)

ELK:

111159821

LLV:

125107477

MPUF:

101684487(CD4)

MNP:	132019914(CD4)

MLK:	131838466(CD4)

NVS:	122891290(CD4)

ORO:	101370279(CD4)

EJU:	114222546(CD4)

ZCA:	113922007(CD4)

MLX:	118025728(CD4)

NSU:	110580959(CD4)

LWW:	102731984(CD4)

FCA:	493775(CD4)

PYU:	121021965(CD4)

PCOO:

112867903(CD4)

PBG:	122473566(CD4)

PVIV:

125169796(CD4)

LRUF:

124501369

LGF:	123590176(CD4)

AJU:

106965350

PTG:	102954103(CD4)

PPAD:

109276110(CD4) 109276152

PUC:

125917982

PLEZ:

122224173(CD4)

HHV:	120220463(CD4)

BTA:	407098(CD4)

BOM:	102281198(CD4)

BIU:	109558922(CD4)

BBUB:

102413723(CD4)

BKE:	129641353(CD4)

BBIS:

104992179(CD4)

CHX:	102170124(CD4)

OAS:	443509(CD4)

BTAX:

128048680(CD4)

CSUM:

138078931(CD4)

ODA:	120858732(CD4)

CCAD:

122423969(CD4)

MREE:

136160095(CD4)

OVR:	110128124(CD4)

MBEZ:

129536212(CD4)

SSC:	404704(CD4)

CFR:	102506854(CD4)

CBAI:

105071091(CD4)

CDK:	105098206(CD4)

VPC:	102530125(CD4)

BACU:

103010726(CD4)

BMUS:

118901712(CD4)

LVE:	103090277(CD4)

OOR:	101285114(CD4)

LALB:

132529184(CD4)

GMF:	115841026(CD4)

DDP:	132434398(CD4)

DLE:	111176687(CD4)

PSIU:

116761015(CD4)

PPHC:

136130519(CD4)

NASI:

112391862(CD4)

ECB:	100052502(CD4)

EPZ:	103547015(CD4)

EAI:	106847327(CD4)

MYB:	102262721(CD4)

MYD:	102760024(CD4)

MMYO:

118651657(CD4)

MLF:	102427698(CD4)

MDT:	132227208(CD4)

MYUM:

139005705(CD4)

PKL:	118729334(CD4)

EFUS:

103289023(CD4)

MNA:	107544013(CD4)

DRO:	112322003(CD4)

SHON:

119002350(CD4)

AJM:	119060419(CD4)

PDIC:

114513512(CD4)

PHAS:

123810628(CD4)

MMF:	118623896(CD4)

PPAM:

129071444 129071445(CD4)

HAI:	109373637(CD4)

RFQ:	117028935(CD4)

PGIG:

120611664(CD4)

PVP:	105295953(CD4)

MJV:	108403555(CD4)

TOD:	119247775(CD4)

SARA:

101544961(CD4)

SFUM:

130016198(CD4)

SETR:

126006959(CD4)

LAV:	100675007(CD4)

TMU:

101343648

ETF:	101661201(CD4)

DNM:	101411381(CD4)

MDO:	100016045(CD4)

GAS:	123250035(CD4)

SHR:	100923185(CD4)

AFZ:

127564449

PCW:	110213788(CD4)

TVP:	118851692(CD4)

PBRV:

138171975(CD4)

OAA:	103165339(CD4)

TACU:

119946630(CD4)

GGA:	395362(CD4)

PCOC:

116239941

MGP:	100126554(CD4)

CJO:

107318700

TPAI:

128089886

LMUT:

125685280

NMEL:

110398410(CD4)

APLA:

101790140(CD4)

AACU:

137864960(CD4)

ACYG:

106047858(CD4)

CATA:

118247575(CD4)

AFUL:

116491037(CD4)

TGU:	100227917(CD4)

LSR:	110480811(CD4)

SCAN:

103812453(CD4)

PMOA:

120506408(CD4)

OTC:	121339345(CD4)

PRUF:

121351620(CD4)

ATRC:

139593181(CD4)

GFR:	102039868(CD4)

FAB:	101811036(CD4)

OMA:	130248364(CD4)

PHI:	102112871(CD4)

PMAJ:

107203925(CD4)

CCAE:

111938276(CD4)

CCW:	104687125(CD4)

CBRC:

103614061(CD4)

ACOE:

138119493(CD4)

ETL:

114058187

ZAB:	102073639(CD4)

ZLE:	135442737(CD4)

ACHL:

103810992

SVG:	106857890(CD4)

MMEA:

130574787(CD4)

HRT:	120748906(CD4)

SATI:

136375555

CCIC:

134056616(CD4)

FPG:	101918856(CD4)

FCH:

CCRI:

NNT:

SHAB:

ACUN:

113476745(CD4)

TALA:

104360758(CD4)

ACHC:

115344140(CD4)

HALD:

104322098

HLE:

104831770

AGEN:

126048957

HHAR:

128145270(CD4)

BBUT:

142034078(CD4)

GCL:

127015266

CSTI:

104560659

LDI:

104346293

MNB:	103768050(CD4)

DPUB:

PPUS:

AVIT:

BRHI:

EGZ:	104126598(CD4)

NNI:

PCRI:

PCAO:

PADL:

AFOR:

FGA:

CBOR:

142088898(CD4)

GSTE:

104256801

CBOY:

140646661(CD4)

MAME:

142404775(CD4)

CLV:	102084034(CD4)

CNIC:

135997871

MUI:	104543498(CD4)

PGUU:

PLET:

EHS:

CMAC:

CUCA:

TEO:

BREG:

OHA:

ACAR:

104519383(CD4)

CPEA:

104389907(CD4)

CVF:

104293427

RTD:	128904246(CD4)

CRID:

134509843(CD4)

LMIC:

141745170(CD4)

AAM:

106497174

AROW:

112963141(CD4)

NPD:	112960135(CD4)

TGT:

104565681

DNE:	112991055(CD4)

SCAM:

104150715

ASN:	102380067(CD4)

AMJ:	102572958(CD4)

CPOO:

109319394(CD4)

GGN:	109304868(CD4)

PSS:	102461725(CD4)

CIZ:	142012267(CD4)

CMY:	102933832(CD4)

CCAY:

125622609(CD4)

LKP:	140905602(CD4)

NDS:	141984694(CD4)

DCC:	119845987(CD4)

CPIC:

101943745(CD4)

TST:	117885813(CD4)

CABI:

116837532(CD4)

MRV:	120395998(CD4)

ACS:	100567219(cd4)

ASAO:

PVT:

SUND:

PBI:

PMUR:

CTIG:

TSR:

PGUT:

PCAE:

139311027(CD4)

APRI:

PTEX:

NSS:

VKO:

PMUA:

PRAF:

ZVI:

HCG:

GJA:

STOW:

125437022(CD4)

XLA:	100653504(cd4.S) 108696056(cd4.L)

XTR:

100491070

NPR:

108795996

RTEM:

120909823 120909824

ACAT:

141105520 141105521(CD4)

PADS:

140339597 140339904

BBUF:

121004931 121005177

BGAR:

122941165 122942428

DTC:	141056066 141056230(CD4)

PWL:	138303722(CD4)

MUO:	115457814(CD4)

GSH:

117350309

DRE:	799982(cd4-1)

SRX:	107717420 107755530

SANH:

107671215 107700156

SGH:	107578959 107598455

CCAR:

109070695(cd4-1)

CAUA:

113059967 113116393

CGIB:

127974323 128031132

PTET:

122359874(cd4-1)

LROH:

127178071(cd4-1)

OMC:	131521872(cd4-1)

PPRM:

120484373(cd4-1)

RKG:	130103629(cd4-1)

MAMB:

125243632 125244174 125244178

CIDE:

127496790

CERY:

137032024 137032086

MASI:

127453273 127453958

TROS:

130558465(cd4-1)

TDW:	130433490(cd4-1)

MANU:

129448423(cd4-1)

PDAB:

135727821 135743442 135743443

IPU:	100304978(cd4-1)

IFU:	128608038(cd4-1)

PHYP:

113542643

SMEO:

124385209(cd4-1)

TFD:	113643587(cd4-1)

TVC:	132846110(cd4-1)

CGAR:

128519786(cd4-1)

NGRA:

132886668(cd4-1)

TRN:	134310088(cd4-1)

AMEX:

103041570(cd4-1)

CMAO:

118824754(cd4-1)

EEE:

113570626

CHAR:

105894549(cd4-1)

SPIL:

134083252(cd4-1)

TRU:	778001(cd4)

TFS:	130532967(cd4-1)

LCO:

104922282

TBEN:

117494722(cd4-1)

CGOB:

115021281

PGEO:

117461231(cd4-1)

GACU:

117549561(cd4-1)

EMAC:

134861266(cd4-1)

ELY:	117265662(cd4-1)

EFO:	125893133(cd4-1)

PLEP:

121945264(cd4-1)

SLUC:

116049734(cd4-1)

ECRA:

117946240(cd4-1)

ESP:

116691255

PFLV:

114557493

GAT:	120810838(cd4-1)

PPUG:

119197243(cd4-1)

AFB:

129109537

CLUM:

117745461(cd4-1)

CANA:

137781150(cd4-1)

CVE:	137891021(cd4-1)

MSAM:

119897409

SCHU:

122882046(cd4-1)

EARM:

139289799(cd4-1)

CUD:	121513840(cd4-1)

SPUL:

138583880(cd4-1)

LMIX:

132983047(cd4-1)

HTC:	141800613(cd4-1)

ALAT:

119006345(cd4-1)

ASTR:

137601720(cd4-1)

PKLU:

139205101(cd4-1)

MZE:

101464216

ONL:

100709183

OAU:	116323777(cd4-1)

OLA:

100125525

OML:	112143674(cd4-1)

CSAI:

XMA:

XCO:

XHE:

PRET:

PFOR:

PLAI:

PMEI:

GAF:	122830983(cd4-1)

PPRL:

129371161(cd4-1)

CVG:

107082188

CTUL:

119783101(cd4-1)

GMU:

124865839

NFU:

107379481

KMR:	108235418(cd4-1)

ALIM:

106521019

NWH:	119409696(cd4-1)

AOCE:

111569482(cd4-1)

EJA:	138191955(cd4-1)

BFRE:

138619222

MCEP:

125016771(cd4-1)

CSEM:

103388025

POV:

109633355

SSEN:

122765142 122774511(cd4-1)

SSOE:

131471486(cd4-1)

HHIP:

117776805(cd4-2.2)

HSP:	118113203(cd4-2.2)

PPLT:

128449611

SMAU:

118315132(cd4-1)

LCF:	108880732(cd4-1)

SDU:

111230068

SLAL:

111669902

XGL:	120784094(cd4-1)

HCQ:

109515260

SBIA:

133500402(cd4-1)

PEE:	133402072(cd4-1)

PTAO:

133480137(cd4-1)

MALB:

109966202

BSPL:

114842934(cd4-1)

SJO:	128365862(cd4-1)

SSCO:

133982934

SASA:

100136501 100136502(CD4)

STRU:

115176380 115177282

OTW:	112223122(cd4-1) 112246591

OMY:	100136285(cd4-1) 110501538

OGO:	123997554 124005545

ONE:	115141342 115141355

OKI:	109902185 109910298

OKE:	118364237 118366528

OMM:	135520052 135522445

OCLA:

139366845 139394335

SALP:

111965239 111965255

SNH:	120031194 120048302

SFON:

ELS:

OEP:

SFM:

PKI:

AANG:

118213758(cd4-1)

AROT:

135240856

CCOG:

133124786(cd4-1)

LOC:

PSPA:

ARUT:

CPUN:

Reference

PMID:2990730

Authors

Maddon PJ, Littman DR, Godfrey M, Maddon DE, Chess L, Axel R

Title

The isolation and nucleotide sequence of a cDNA encoding the T cell surface protein T4: a new member of the immunoglobulin gene family.

Journal

Cell 42:93-104 (1985)
DOI:10.1016/S0092-8674(85)80105-7

Sequence

[hsa:920]

Reference

PMID:2214026

Authors

Crise B, Buonocore L, Rose JK

Title

CD4 is retained in the endoplasmic reticulum by the human immunodeficiency virus type 1 glycoprotein precursor.

Journal

J Virol 64:5585-93 (1990)
DOI:10.1128/JVI.64.11.5585-5593.1990

LinkDB

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