KEGG   DRUG: Sifalimumab
Entry
D09668                      Drug                                   

Name
Sifalimumab (USAN/INN)
Formula
C6396H9918N1714O2006S42
Exact mass
144177.5032
Mol weight
144266.1963
Sequence
(Heavy chain)
QVQLVQSGAE VKKPGASVKV SCKASGYTFT SYSISWVRQA PGQGLEWMGW ISVYNGNTNY
AQKFQGRVTM TTDTSTSTAY LELRSLRSDD TAVYYCARDP IAAGYWGQGT LVTVSSASTK
GPSVFPLAPS SKSTSGGTAA LGCLVKDYFP EPVTVSWNSG ALTSGVHTFP AVLQSSGLYS
LSSVVTVPSS SLGTQTYICN VNHKPSNTKV DKKVEPKSCD KTHTCPPCPA PELLGGPSVF
LFPPKPKDTL MISRTPEVTC VVVDVSHEDP EVKFNWYVDG VEVHNAKTKP REEQYNSTYR
VVSVLTVLHQ DWLNGKEYKC KVSNKALPAP IEKTISKAKG QPREPQVYTL PPSREEMTKN
QVSLTCLVKG FYPSDIAVEW ESNGQPENNY KTTPPVLDSD GSFFLYSKLT VDKSRWQQGN
VFSCSVMHEA LHNHYTQKSL SLSPGK
(Light chain)
EIVLTQSPGT LSLSPGERAT LSCRASQSVS STYLAWYQQK PGQAPRLLIY GASSRATGIP
DRFSGSGSGT DFTLTISRLE PEDFAVYYCQ QYGSSPRTFG QGTKVEIKRT VAAPSVFIFP
PSDEQLKSGT ASVVCLLNNF YPREAKVQWK VDNALQSGNS QESVTEQDSK DSTYSLSSTL
TLSKADYEKH KVYACEVTHQ GLSSPVTKSF NRGEC
(Disulfide bridge: H22-H96, H143-H199, H260-H320, H366-H424, H225-H'225, H228-H'228, L23-L89, L135-L195, H219-L215)
  Type
Peptide
Efficacy
Immunosuppressant, Anti-IFN-alpha antibody
Comment
Monoclonal antibody
Treatment of SLE, dermatomyositis, and polymyositis
Target
Brite
Target-based classification of drugs [BR:br08310]
 Cytokines and receptors
  Cytokines
   Interferons
    IFNA
     D09668  Sifalimumab (USAN/INN)
Other DBs
CAS: 1006877-41-3
PubChem: 124490408
LinkDB

» Japanese version   » Back

DBGET integrated database retrieval system