KEGG   DRUG: SifalimumabHelp
Entry
D09668                      Drug                                   

Name
Sifalimumab (USAN/INN)
Formula
C6396H9918N1714O2006S42
Exact mass
144177.5032
Mol weight
144266.1963
Sequence
(Heavy chain) QVQLVQSGAE VKKPGASVKV SCKASGYTFT SYSISWVRQA
PGQGLEWMGW ISVYNGNTNY AQKFQGRVTM TTDTSTSTAY LELRSLRSDD TAVYYCARDP
IAAGYWGQGT LVTVSSASTK GPSVFPLAPS SKSTSGGTAA LGCLVKDYFP EPVTVSWNSG
ALTSGVHTFP AVLQSSGLYS LSSVVTVPSS SLGTQTYICN VNHKPSNTKV DKKVEPKSCD
KTHTCPPCPA PELLGGPSVF LFPPKPKDTL MISRTPEVTC VVVDVSHEDP EVKFNWYVDG
VEVHNAKTKP REEQYNSTYR VVSVLTVLHQ DWLNGKEYKC KVSNKALPAP IEKTISKAKG
QPREPQVYTL PPSREEMTKN QVSLTCLVKG FYPSDIAVEW ESNGQPENNY KTTPPVLDSD
GSFFLYSKLT VDKSRWQQGN VFSCSVMHEA LHNHYTQKSL SLSPGK
(Disulfide bridge: 22-96; 143-199; 260-320; 366-424, Dimer: 225; 228)
(Light chain) EIVLTQSPGT LSLSPGERAT LSCRASQSVS STYLAWYQQK
PGQAPRLLIY GASSRATGIP DRFSGSGSGT DFTLTISRLE PEDFAVYYCQ QYGSSPRTFG
QGTKVEIKRT VAAPSVFIFP PSDEQLKSGT ASVVCLLNNF YPREAKVQWK VDNALQSGNS
QESVTEQDSK DSTYSLSSTL TLSKADYEKH KVYACEVTHQ GLSSPVTKSF NRGEC
(Disulfide bridge: 23-89; 135-195; H219-L215)
  Type
Peptide
Efficacy
Immunosuppressant, Anti-IFN-alpha antibody
Comment
Monoclonal antibody
Treatment of SLE, dermatomyositis, and polymyositis
Target
Brite
Target-based classification of drugs [BR:br08310]
 Cytokines and receptors
  Cytokines
   Interferons
    IFNA
     D09668  Sifalimumab (USAN/INN)
BRITE hierarchy
Other DBs
CAS: 1006877-41-3
PubChem: 124490408
LinkDB All DBs

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