Entry
Name
Tonapofylline (USAN/INN)
Formula
C22H32N4O4
Exact mass
416.2424
Mol weight
416.51
Structure
Mol file KCF file DB search
Class
Respiratory system agent
DG01616 Xanthine derivative
DG01614 Xanthine-type vasodilator
Efficacy
Cardiotonic, Adenosine A1 receptor antagonist
Comment
Theophylline derivative
Treatment of heart failure
Target
Pathway
hsa04080 Neuroactive ligand-receptor interaction
Interaction
DDI search
Brite
Drug groups [BR:br08330 ]
Respiratory system agent
DG01616 Xanthine derivative
DG01614 Xanthine-type vasodilator
D09684 Tonapofylline
Target-based classification of drugs [BR:br08310 ]
G Protein-coupled receptors
Rhodopsin family
Adenosine
ADORA1
D09684 Tonapofylline (USAN/INN)
BRITE hierarchy
Other DBs
LinkDB
All DBs
KCF data
Show ATOM 30
1 C1z C 23.0300 -21.5600
2 C8y C 26.4600 -20.9300
3 C8y C 26.4600 -22.2600
4 N4y N 27.6500 -22.9600
5 C8y C 28.8400 -22.2600
6 N4y N 28.8400 -20.9300
7 C8y C 27.6500 -20.2300
8 N4x N 25.2000 -20.5100
9 C8y C 24.3600 -21.5600
10 N5x N 25.2000 -22.6800
11 O5x O 27.6500 -18.9000
12 C1b C 29.9600 -20.2300
13 C1b C 31.2200 -20.9300
14 C1a C 32.3400 -20.2300
15 C1b C 27.6500 -24.2900
16 C1b C 28.7700 -24.9900
17 C1a C 28.7700 -26.3200
18 O5x O 29.9600 -22.9600
19 C1x C 21.5600 -20.3000
20 C1x C 20.6500 -20.8600
21 C1z C 21.7700 -21.6300
22 C1x C 21.7700 -23.1000
23 C1x C 23.0300 -23.1000
24 C1x C 22.8900 -20.0200
25 C1x C 23.8700 -20.7900
26 C1b C 19.3900 -21.6300
27 C1b C 20.5800 -22.3300
28 C6a C 18.1719 -22.3201
29 O6a O 16.9905 -21.6250
30 O6a O 18.2302 -23.7294
BOND 33
1 2 3 2
2 3 4 1
3 4 5 1
4 5 6 1
5 6 7 1
6 2 7 1
7 2 8 1
8 8 9 1
9 9 10 2
10 3 10 1
11 7 11 2
12 1 9 1
13 6 12 1
14 12 13 1
15 13 14 1
16 4 15 1
17 15 16 1
18 16 17 1
19 5 18 2
20 1 19 1
21 19 20 1
22 20 21 1
23 21 22 1
24 1 23 1
25 23 22 1
26 21 24 1
27 24 25 1
28 25 1 1
29 26 27 1
30 27 21 1
31 26 28 1
32 28 29 1
33 28 30 2