| Entry |
|
|---|
| Name |
Dapagliflozin propanediol (USAN);
Dapagliflozin propylene glycolate hydrate (JAN);
Dapagliflozin propandiol monohydrate;
Forxiga (TN);
Farxiga (TN) |
|---|
| Product |
|
|---|
| Generic |
|
|---|
| Formula |
C21H25ClO6. C3H8O2. H2O
|
|---|
| Exact mass |
502.197
|
|---|
| Mol weight |
502.9823
|
|---|
| Structure |
|
|---|
| Simcomp |
|
|---|
| Class |
Antidiabetic agent
DG02044 Hypoglycemic agent
DG01794 SGLT2 inhibitor
Metabolizing enzyme substrate
DG02924 UGT substrate
DG03188 UGT1A9 substrate
|
|---|
| Remark |
| Product (DG00122): | D09763<JP/US> |
| Product (mixture): | D10586<US> D10826<US> |
|
|---|
| Efficacy |
Antidiabetic, SGLT-2 inhibitor |
|---|
| Disease |
Type 2 diabetes mellitus [DS: H00409] |
|---|
| Comment |
Phlorizin derivative
|
|---|
| Target |
|
|---|
| Metabolism |
Enzyme: UGT1A9 [HSA: 54600]
|
|---|
| Interaction |
|
|---|
| Structure map |
|
|---|
| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
A ALIMENTARY TRACT AND METABOLISM
A10 DRUGS USED IN DIABETES
A10B BLOOD GLUCOSE LOWERING DRUGS, EXCL. INSULINS
A10BK Sodium-glucose co-transporter 2 (SGLT2) inhibitors
A10BK01 Dapagliflozin
D09763 Dapagliflozin propanediol (USAN) <JP/US>
USP drug classification [BR:br08302]
Blood Glucose Regulators
Antidiabetic Agents
Sodium-Glucose Co-Transporter 2 (SGLT2) Inhbitor
Dapagliflozin
D09763 Dapagliflozin propanediol (USAN)
Cardiovascular Agents
Sodium-Glucose Co-Transporter 2 Inhibitors (SGLT2i)
Dapagliflozin
D09763 Dapagliflozin propanediol (USAN)
Therapeutic category of drugs in Japan [BR:br08301]
2 Agents affecting individual organs
21 Cardiovascular agents
219 Miscellaneous
2190 Miscellaneous
D09763 Dapagliflozin propanediol (USAN); Dapagliflozin propylene glycolate hydrate (JAN)
3 Agents affecting metabolism
39 Other agents affecting metabolism
396 Antidiabetic agents
3969 Others
D09763 Dapagliflozin propanediol (USAN); Dapagliflozin propylene glycolate hydrate (JAN)
399 Miscellaneous
3999 Others
D09763 Dapagliflozin propanediol (USAN); Dapagliflozin propylene glycolate hydrate (JAN)
Drug groups [BR:br08330]
Antidiabetic agent
DG02044 Hypoglycemic agent
DG01794 SGLT2 inhibitor
DG00122 Dapagliflozin
D09763 Dapagliflozin propanediol
Metabolizing enzyme substrate
DG02924 UGT substrate
DG03188 UGT1A9 substrate
DG00122 Dapagliflozin
D09763 Dapagliflozin propanediol
Drug classes [BR:br08332]
Antidiabetic agent
DG01794 SGLT2 inhibitor
D09763 Dapagliflozin propanediol
DG02044 Hypoglycemic agent
D09763 Dapagliflozin propanediol
Target-based classification of drugs [BR:br08310]
Transporters
Solute carrier family
SLC5
SLC5A2 (SGLT2)
D09763 Dapagliflozin propanediol (USAN) <JP/US>
New drug approvals in the USA [br08319.html]
New molecular entities and new therapeutic biological products
D09763
New drug approvals in Europe [br08329.html]
European public assessment reports (EPAR) authorised medicine
D09763
New drug approvals in Japan [br08318.html]
Drugs with new active ingredients
D09763
New drug approvals in the USA, Europe and Japan [br08328.html]
Approval dates by FDA, EMA and PMDA
D09763
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
D09763
Drug groups [BR:br08330]
Antidiabetic agent
DG02044 Hypoglycemic agent
DG01794 SGLT2 inhibitor
DG00122 Dapagliflozin
Metabolizing enzyme substrate
DG02924 UGT substrate
DG03188 UGT1A9 substrate
DG00122 Dapagliflozin
|
|---|
| Other DBs |
|
|---|
| LinkDB |
|
|---|
| KCF data |
ATOM 34
1 C8y C 8.1200 -20.5100
2 C8x C 8.1200 -21.9100
3 C8x C 9.3100 -22.6100
4 C8y C 10.5700 -21.9100
5 C8y C 10.5700 -20.5100
6 C8x C 9.3100 -19.8100
7 C1b C 11.7600 -19.8100
8 C8y C 13.0200 -20.5100
9 C8x C 13.0200 -21.9100
10 C8x C 14.2100 -22.6100
11 C8y C 15.4000 -21.9100
12 C8x C 15.4000 -20.5100
13 C8x C 14.2100 -19.8100
14 X Cl 11.7600 -22.6100
15 O2a O 16.5900 -22.6100
16 C1b C 17.7800 -21.9100
17 C1a C 18.9700 -22.6100
18 C1y C 6.9300 -19.8100
19 O2x O 6.9300 -18.4100
20 C1y C 5.6700 -17.7100
21 C1y C 4.4800 -18.4100
22 C1y C 4.4800 -19.8100
23 C1y C 5.6700 -20.5100
24 O1a O 5.6700 -21.9100
25 O1a O 3.2900 -17.7100
26 O1a O 3.2900 -20.5100
27 C1b C 5.6700 -16.3100
28 O1a O 6.9300 -15.6100
29 C1a C 15.9600 -15.8200
30 C1c C 17.1724 -16.5200
31 C1b C 18.3679 -15.8296
32 O1a O 17.1725 -17.9198
33 O1a O 19.5553 -16.5151
34 O0 O 20.7200 -20.0200
BOND 34
1 1 2 2
2 2 3 1
3 3 4 2
4 4 5 1
5 5 6 2
6 1 6 1
7 5 7 1
8 7 8 1
9 8 9 2
10 9 10 1
11 10 11 2
12 11 12 1
13 12 13 2
14 8 13 1
15 4 14 1
16 11 15 1
17 15 16 1
18 16 17 1
19 18 1 1 #Up
20 18 19 1
21 19 20 1
22 20 21 1
23 21 22 1
24 22 23 1
25 18 23 1
26 23 24 1 #Down
27 21 25 1 #Down
28 22 26 1 #Up
29 20 27 1 #Up
30 27 28 1
31 29 30 1
32 30 31 1
33 30 32 1
34 31 33 1
|
|---|
