KEGG   DRUG: Dapagliflozin propanediolHelp
Entry
D09763                      Drug                                   

Name
Dapagliflozin propanediol (USAN);
Dapagliflozin propylene glycolate hydrate (JAN);
Dapagliflozin propandiol monohydrate;
Forxiga (TN);
Farxiga (TN)
Product
Formula
C21H25ClO6. C3H8O2. H2O
Exact mass
502.197
Mol weight
502.9823
Structure
Mol fileKCF fileDB search
Simcomp SIMCOMP
Class
Antidiabetic agent
 DG01794  SGLT2 inhibitor
 DG02044  Hypoglycemics
  DG01794  SGLT2 inhibitor
Metabolizing enzyme substrate
 DG02924  UGT substrate
Remark
Therapeutic category: 3969
ATC code: A10BK01
Chemical structure group: DG00122
Product (DG00122): D09763<JP/US>
Product (mixture): D10586<US>
Efficacy
Antidiabetic, SGLT-2 inhibitor
  Disease
Type 2 diabetes mellitus [DS:H00409]
Comment
Phlorizin derivative
Target
SLC5A2 (SGLT2) [HSA:6524] [KO:K14382]
Metabolism
Enzyme: UGT1A9 [HSA:54600]
Interaction
Drug interaction
Structure map
map07051  Antidiabetics
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 A ALIMENTARY TRACT AND METABOLISM
  A10 DRUGS USED IN DIABETES
   A10B BLOOD GLUCOSE LOWERING DRUGS, EXCL. INSULINS
    A10BK Sodium-glucose co-transporter 2 (SGLT2) inhibitors
     A10BK01 Dapagliflozin
      D09763  Dapagliflozin propanediol (USAN) <JP/US>
USP drug classification [BR:br08302]
 Blood Glucose Regulators
  Antidiabetic Agents
   Dapagliflozin
    D09763  Dapagliflozin propanediol (USAN)
Therapeutic category of drugs in Japan [BR:br08301]
 3  Agents affecting metabolism
  39  Other agents affecting metabolism
   396  Antidiabetic agents
    3969  Others
     D09763  Dapagliflozin propanediol (USAN); Dapagliflozin propylene glycolate hydrate (JAN)
Target-based classification of drugs [BR:br08310]
 Transporters
  Solute carrier family
   SLC5
    SLC5A2 (SGLT2)
     D09763  Dapagliflozin propanediol (USAN) <JP/US>
New drug approvals in the USA [br08319.html]
 New molecular entities and new therapeutic biological products
  D09763
New drug approvals in Europe [br08329.html]
 European public assessment reports (EPAR) authorised medicine
  D09763
New drug approvals in Japan [br08318.html]
 Drugs with new active ingredients
  D09763
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D09763
BRITE hierarchy
Other DBs
CAS: 960404-48-2
PubChem: 124490503
ChEBI: 85079
LigandBox: D09763
LinkDB All DBs
KCF data Show

ATOM        34
            1   C8y C     8.1200  -20.5100
            2   C8x C     8.1200  -21.9100
            3   C8x C     9.3100  -22.6100
            4   C8y C    10.5700  -21.9100
            5   C8y C    10.5700  -20.5100
            6   C8x C     9.3100  -19.8100
            7   C1b C    11.7600  -19.8100
            8   C8y C    13.0200  -20.5100
            9   C8x C    13.0200  -21.9100
            10  C8x C    14.2100  -22.6100
            11  C8y C    15.4000  -21.9100
            12  C8x C    15.4000  -20.5100
            13  C8x C    14.2100  -19.8100
            14  X   Cl   11.7600  -22.6100
            15  O2a O    16.5900  -22.6100
            16  C1b C    17.7800  -21.9100
            17  C1a C    18.9700  -22.6100
            18  C1y C     6.9300  -19.8100
            19  O2x O     6.9300  -18.4100
            20  C1y C     5.6700  -17.7100
            21  C1y C     4.4800  -18.4100
            22  C1y C     4.4800  -19.8100
            23  C1y C     5.6700  -20.5100
            24  O1a O     5.6700  -21.9100
            25  O1a O     3.2900  -17.7100
            26  O1a O     3.2900  -20.5100
            27  C1b C     5.6700  -16.3100
            28  O1a O     6.9300  -15.6100
            29  C1a C    15.9600  -15.8200
            30  C1c C    17.1724  -16.5200
            31  C1b C    18.3679  -15.8296
            32  O1a O    17.1725  -17.9198
            33  O1a O    19.5553  -16.5151
            34  O0  O    20.7200  -20.0200
BOND        34
            1     1   2 2
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 2
            6     1   6 1
            7     5   7 1
            8     7   8 1
            9     8   9 2
            10    9  10 1
            11   10  11 2
            12   11  12 1
            13   12  13 2
            14    8  13 1
            15    4  14 1
            16   11  15 1
            17   15  16 1
            18   16  17 1
            19   18   1 1 #Up
            20   18  19 1
            21   19  20 1
            22   20  21 1
            23   21  22 1
            24   22  23 1
            25   18  23 1
            26   23  24 1 #Down
            27   21  25 1 #Down
            28   22  26 1 #Up
            29   20  27 1 #Up
            30   27  28 1
            31   29  30 1
            32   30  31 1
            33   30  32 1
            34   31  33 1

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