KEGG   DRUG: Lesinurad
Entry
D09921                      Drug                                   
Name
Lesinurad (USAN/INN);
Zurampic (TN)
Formula
C17H14BrN3O2S
Exact mass
402.999
Mol weight
404.281
Structure
Simcomp
Class
Musculo-skeletal system agent
 DG02042  Uricosurics
Metabolizing enzyme substrate
 DG01642  CYP2C9 substrate
Remark
ATC code: M04AB05
Chemical structure group: DG01388
Efficacy
Gout suppressant, Uricosuric, Urate transporter inhibitor
  Disease
Gout [DS:H01532]
Comment
Treatment of hyperuricemia associated with gout
Target
URAT1 [HSA:116085] [KO:K08208]
OAT4 [HSA:55867] [KO:K08207]
Metabolism
Enzyme: CYP2C9 [HSA:1559]
Interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 M MUSCULO-SKELETAL SYSTEM
  M04 ANTIGOUT PREPARATIONS
   M04A ANTIGOUT PREPARATIONS
    M04AB Preparations increasing uric acid excretion
     M04AB05 Lesinurad
      D09921  Lesinurad (USAN/INN)
Drug groups [BR:br08330]
 Musculo-skeletal system agent
  DG02042  Uricosurics
   DG01388  Lesinurad
    D09921  Lesinurad
 Metabolizing enzyme substrate
  DG01642  CYP2C9 substrate
   DG01388  Lesinurad
    D09921  Lesinurad
Target-based classification of drugs [BR:br08310]
 Transporters
  Solute carrier family
   SLC22
    OAT4
     D09921  Lesinurad (USAN/INN)
    URAT1
     D09921  Lesinurad (USAN/INN)
New drug approvals in the USA [br08319.html]
 New molecular entities and new therapeutic biological products
  D09921
New drug approvals in Europe [br08329.html]
 European public assessment reports (EPAR) authorised medicine
  D09921
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D09921
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D09921
Pharmacogenomic biomarkers [br08341.html]
 Polymorphisms and mutations affecting drug response
  D09921
Drug groups [BR:br08330]
 Musculo-skeletal system agent
  DG02042  Uricosurics
   DG01388  Lesinurad
 Metabolizing enzyme substrate
  DG01642  CYP2C9 substrate
   DG01388  Lesinurad
Other DBs
CAS: 878672-00-5
PubChem: 135626658
ChEBI: 90929
LigandBox: D09921
LinkDB
KCF data

ATOM        24
            1   C8x C    15.4812  -25.6868
            2   C8x C    15.4812  -27.0963
            3   C8y C    16.6793  -27.8011
            4   C8y C    17.9479  -27.0963
            5   C8y C    17.9479  -25.6868
            6   C8y C    16.6793  -24.9821
            7   C8x C    19.1460  -27.8011
            8   C8x C    20.3440  -27.0963
            9   C8x C    20.3440  -25.6868
            10  C8x C    19.1460  -24.9821
            11  N4y N    16.6793  -23.5726
            12  C8y C    17.8069  -22.7269
            13  N5x N    17.3841  -21.4583
            14  N5x N    15.9746  -21.4583
            15  C8y C    15.5517  -22.7269
            16  S2a S    19.0050  -23.4316
            17  C1b C    20.2031  -22.7269
            18  C6a C    21.4012  -23.4316
            19  O6a O    22.5992  -22.7269
            20  O6a O    21.4012  -24.8411
            21  X   Br   14.2064  -23.1471
            22  C1y C    16.6620  -29.2105
            23  C1x C    15.9573  -30.4311
            24  C1x C    17.3668  -30.4311
BOND        27
            1     1   2 1
            2     2   3 2
            3     3   4 1
            4     4   5 2
            5     5   6 1
            6     1   6 2
            7     4   7 1
            8     7   8 2
            9     8   9 1
            10    9  10 2
            11    5  10 1
            12    6  11 1
            13   11  12 1
            14   12  13 2
            15   13  14 1
            16   14  15 2
            17   11  15 1
            18   12  16 1
            19   16  17 1
            20   17  18 1
            21   18  19 1
            22   18  20 2
            23   15  21 1
            24    3  22 1
            25   22  23 1
            26   22  24 1
            27   23  24 1

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