KEGG   DRUG: LesinuradHelp
Entry
D09921                      Drug                                   

Name
Lesinurad (USAN/INN);
Zurampic (TN)
Product
Formula
C17H14BrN3O2S
Exact mass
402.999
Mol weight
404.281
Structure
Mol fileKCF fileDB search
Simcomp SIMCOMP
Class
Other
 DG02042  Uricosurics
Metabolizing enzyme substrate
 DG01642  CYP2C9 substrate
Remark
ATC code: M04AB05
Chemical structure group: DG01388
Product (DG01388): D09921<US>
Product (mixture): D11175<US>
Efficacy
Gout suppressant, Uricosuric, Urate transporter inhibitor
  Disease
Gout [DS:H01532]
Comment
Treatment of hyperuricemia associated with gout
Target
URAT1 [HSA:116085] [KO:K08208]
OAT4 [HSA:55867] [KO:K08207]
Metabolism
Enzyme: CYP2C9 [HSA:1559]
Interaction
Drug interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 M MUSCULO-SKELETAL SYSTEM
  M04 ANTIGOUT PREPARATIONS
   M04A ANTIGOUT PREPARATIONS
    M04AB Preparations increasing uric acid excretion
     M04AB05 Lesinurad
      D09921  Lesinurad (USAN/INN) <US>
USP drug classification [BR:br08302]
 Antigout Agents
  Lesinurad
   D09921  Lesinurad (USAN/INN)
Target-based classification of drugs [BR:br08310]
 Transporters
  Solute carrier family
   SLC22
    OAT4
     D09921  Lesinurad (USAN/INN) <US>
    URAT1
     D09921  Lesinurad (USAN/INN) <US>
New drug approvals in the USA [br08319.html]
 New molecular entities and new therapeutic biological products
  D09921
New drug approvals in Europe [br08329.html]
 European public assessment reports (EPAR) authorised medicine
  D09921
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D09921
Pharmacogenomic biomarkers [br08341.html]
 Polymorphisms and mutations affecting drug response
  D09921
BRITE hierarchy
Other DBs
CAS: 878672-00-5
PubChem: 135626658
ChEBI: 90929
ChEMBL: CHEMBL2105720
LigandBox: D09921
LinkDB All DBs
KCF data Show

ATOM        24
            1   C8x C    15.4812  -25.6868
            2   C8x C    15.4812  -27.0963
            3   C8y C    16.6793  -27.8011
            4   C8y C    17.9479  -27.0963
            5   C8y C    17.9479  -25.6868
            6   C8y C    16.6793  -24.9821
            7   C8x C    19.1460  -27.8011
            8   C8x C    20.3440  -27.0963
            9   C8x C    20.3440  -25.6868
            10  C8x C    19.1460  -24.9821
            11  N4y N    16.6793  -23.5726
            12  C8y C    17.8069  -22.7269
            13  N5x N    17.3841  -21.4583
            14  N5x N    15.9746  -21.4583
            15  C8y C    15.5517  -22.7269
            16  S2a S    19.0050  -23.4316
            17  C1b C    20.2031  -22.7269
            18  C6a C    21.4012  -23.4316
            19  O6a O    22.5992  -22.7269
            20  O6a O    21.4012  -24.8411
            21  X   Br   14.2064  -23.1471
            22  C1y C    16.6620  -29.2105
            23  C1x C    15.9573  -30.4311
            24  C1x C    17.3668  -30.4311
BOND        27
            1     1   2 1
            2     2   3 2
            3     3   4 1
            4     4   5 2
            5     5   6 1
            6     1   6 2
            7     4   7 1
            8     7   8 2
            9     8   9 1
            10    9  10 2
            11    5  10 1
            12    6  11 1
            13   11  12 1
            14   12  13 2
            15   13  14 1
            16   14  15 2
            17   11  15 1
            18   12  16 1
            19   16  17 1
            20   17  18 1
            21   18  19 1
            22   18  20 2
            23   15  21 1
            24    3  22 1
            25   22  23 1
            26   22  24 1
            27   23  24 1

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