| Entry |
|
|---|
| Name |
Lesinurad sodium (USAN) |
|---|
| Formula |
C17H13BrN3O2S. Na
|
|---|
| Exact mass |
424.9810
|
|---|
| Mol weight |
426.26
|
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| Structure |
|
|---|
| Simcomp |
|
|---|
| Class |
Musculo-skeletal system agent
DG02042 Uricosurics
DG03334 Urate transporter inhibitor
Metabolizing enzyme substrate
DG01642 CYP2C9 substrate
|
|---|
| Remark |
|
|---|
| Efficacy |
Gout suppressant, Uricosuric, Urate transporter inhibitor, Organic anion transporter inhibitor |
|---|
| Target |
|
|---|
| Metabolism |
Enzyme: CYP2C9 [HSA: 1559]
|
|---|
| Interaction |
|
|---|
| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
M MUSCULO-SKELETAL SYSTEM
M04 ANTIGOUT PREPARATIONS
M04A ANTIGOUT PREPARATIONS
M04AB Preparations increasing uric acid excretion
M04AB05 Lesinurad
D09922 Lesinurad sodium (USAN)
Drug groups [BR:br08330]
Musculo-skeletal system agent
DG02042 Uricosurics
DG01388 Lesinurad
D09922 Lesinurad sodium
DG03334 Urate transporter inhibitor
DG01388 Lesinurad
D09922 Lesinurad sodium
Metabolizing enzyme substrate
DG01642 CYP2C9 substrate
DG01388 Lesinurad
D09922 Lesinurad sodium
Target-based classification of drugs [BR:br08310]
Transporters
Solute carrier family
SLC22
SLC22A11 (OAT4)
D09922 Lesinurad sodium (USAN)
SLC22A12 (URAT1)
D09922 Lesinurad sodium (USAN)
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
D09922
Drug groups [BR:br08330]
Musculo-skeletal system agent
DG02042 Uricosurics
DG01388 Lesinurad
DG03334 Urate transporter inhibitor
DG01388 Lesinurad
Metabolizing enzyme substrate
DG01642 CYP2C9 substrate
DG01388 Lesinurad
|
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| Other DBs |
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| LinkDB |
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| KCF data |
ATOM 25
1 C8x C 14.6980 -25.6865
2 C8x C 14.6980 -27.0864
3 C8y C 15.8879 -27.7863
4 C8y C 17.1477 -27.0864
5 C8y C 17.1477 -25.6865
6 C8y C 15.8879 -24.9866
7 C8x C 18.4075 -27.7863
8 C8x C 19.5974 -27.0864
9 C8x C 19.5974 -25.6865
10 C8x C 18.4075 -24.9866
11 N4y N 15.8879 -23.5868
12 C8y C 17.0077 -22.7469
13 N5x N 16.5878 -21.4871
14 N5x N 15.1880 -21.4871
15 C8y C 14.7680 -22.7469
16 S2a S 18.2675 -23.4468
17 C1b C 19.4574 -22.7469
18 C6a C 20.6472 -23.4468
19 O6a O 21.8371 -22.7469 #-
20 O6a O 20.6472 -24.8467
21 X Br 13.4382 -23.1669
22 C1y C 15.8879 -29.1861
23 C1x C 15.1880 -30.4459
24 C1x C 16.5878 -30.4459
25 Z Na 23.3769 -22.7469 #+
BOND 27
1 1 2 1
2 2 3 2
3 3 4 1
4 4 5 2
5 5 6 1
6 1 6 2
7 4 7 1
8 7 8 2
9 8 9 1
10 9 10 2
11 5 10 1
12 6 11 1
13 11 12 1
14 12 13 2
15 13 14 1
16 14 15 2
17 11 15 1
18 12 16 1
19 16 17 1
20 17 18 1
21 18 19 1
22 18 20 2
23 15 21 1
24 3 22 1
25 22 23 1
26 22 24 1
27 23 24 1
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